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The implementation of a national genomic newborn screening programme in the English NHS: Early lessons from the Generation Study

Vindrola-Padros C, Clark S, Gilchrist K, Brady G, Beecham E, McLeod A, Boardman F, Vu M, Buchanan J, Hill M, Lewis C.   +10 more
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Deep learning: new computational modelling techniques for genomics

Nature Reviews Genetics, 2019
Gökçen Eraslan, Ziga Avsec, Julien Gagneur   +2 more
exaly   +2 more sources

Genome – which genome?

Trends in Parasitology, 2001
It is entirely natural that molecular biologists should enthuse about the prospects that their science proffers 8xHurrah for genome projects. Ivens, A. Parasitol. Today. 2000; 16: 317–320Abstract | Full Text | Full Text PDF | PubMed | Scopus (6)See all References8.
I, Maudlin, S C, Welburn
openaire   +3 more sources

Redundancy analysis: A Swiss Army Knife for landscape genomics

Methods in Ecology and Evolution, 2021
Landscape genomics identifies how spatial and environmental factors structure the amount and distribution of genetic variation among populations. Landscape genomic analyses have been applied across diverse taxonomic groups and ecological settings, and ...
Thibaut Capblancq, B. Forester
semanticscholar   +1 more source

Combing the genome for genomic instability

Trends in Biotechnology, 2002
Genomic instability is one of the major features of cancer cells. The clinical phenotypes associated with several human diseases have been linked to recurrent DNA rearrangements and dysfunction of DNA replication processes that involve unstable genomic regions.
Sandrine, Caburet, Chiara, Conti, Aaron, Bensimon   +2 more
openaire   +2 more sources

Genomics and functional genomics with haloarchaea

Archives of Microbiology, 2008
The first haloarchaeal genome was published in 2000 and today five genome sequences are available. Transcriptome and proteome analyses have been established for two and three haloarchaeal species, respectively, and more than 20 studies using these functional genomic approaches have been published in the last two years.
J, Soppa, A, Baumann, M, Brenneis, M, Dambeck, O, Hering, C, Lange   +5 more
openaire   +2 more sources

JCVI: A versatile toolkit for comparative genomics analysis

iMeta
The life cycle of genome builds spans interlocking pillars of assembly, annotation, and comparative genomics to drive biological insights. While tools exist to address each pillar separately, there is a growing need for tools to integrate different ...
Haibao Tang, V. Krishnakumar, Xiaofei Zeng, Zhougeng Xu, Adam P Taranto, Johnathan S Lomas, Yixing Zhang, Yumin Huang, Yibin Wang, W. C. Yim, Jisen Zhang, Xingtan Zhang   +11 more
semanticscholar   +1 more source

The ‘Persons‘ and ‘Genomics‘ of Personal Genomics

Personalized Medicine, 2010
At stake in the debate about personal genomics is what kind of person can be trusted to interpret genomes. Deciding this hinges not just on determining if consumers can interpret genomic information, but on deciding which biological and medical experts (if any) can perform these interpretive acts.
openaire   +2 more sources

The re-emergence of natural products for drug discovery in the genomics era

Nature reviews. Drug discovery, 2015
Natural products have been a rich source of compounds for drug discovery. However, their use has diminished in the past two decades, in part because of technical barriers to screening natural products in high-throughput assays against molecular targets ...
A. Harvey, R. Edrada-Ebel, R. Quinn
semanticscholar   +1 more source

Genome Walking

2013
Genome walking is a method for determining the DNA sequence of unknown genomic regions flanking a region of known DNA sequence. The Genome walking has the potential to capture 6-7 kb of sequence in a single round. Ideal for identifying gene promoter regions where only the coding region.
Shapter, Frances M, Waters, Daniel L E
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