Results 231 to 240 of about 89,616 (295)
The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Environmental pollution and climate change seriously affect human health, leading to the onset and exacerbation of chronic respiratory diseases, such as allergic rhinitis and lung diseases. Over the past several decades, increasing air pollution and environmental exposure owing to global urbanization, industrialization, and rapid economic ...
Xin‐Yan Liu +4 more
wiley +1 more source
AZT IS A GENOTOXIC TRANSPLACENTAL CARCINOGEN IN ANIMAL MODELS
, 1997 Ofelia A. Olivero +9 more
openalex +1 more source
Enhancing Late‐Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels
Aging Cell, EarlyView.RNAi knockdown (KD) of mcu‐1 or mitoxantrone treatment lowers mitochondrial Ca2+, extends lifespan, and preserves motility during aging. Benefits require early intervention and involve a transient ROS increase that activates a pmk‐1, daf‐16, and skn‐1 pathway, enhancing stress defense and mitochondrial integrity while reducing early‐life survival ...
Doruntina Bresilla +13 more
wiley +1 more source
In Vivo Genotoxic Effects of Spiramycin in Rat Bone Marrow Cells.
, 1999 Hasan Basri İla, Mehmet Topaktaş
openalex +2 more sources
British Journal of Pharmacology, EarlyView.Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley +1 more source
Cancer Science, EarlyView.This case study describes the clinical course of a 39‐year‐old woman with metastatic breast cancer harboring a germline PALB2 mutation who was treated with a PARP inhibitor. Figure shows the PALB2 reverse mutation detected by liquid biopsy genomic profiling. The top panel shows a schematic diagram of the wild‐type PALB2 sequence. The second panel shows
Maako Kawamura +10 more
wiley +1 more source
Cancer Science, EarlyView.Just as the term “cancer cell” encompasses a wide spectrum of cells, the term “senescent cell” should also be regarded as an umbrella term that includes cells with heterogeneous molecular profiles. In this review, we provide an updated overview of the molecular mechanisms underlying distinct senescent cell subtypes induced by various stimuli, including
Enaam Alghamdi, Keiko Kono
wiley +1 more source
162 STUDY ON THE POTENTIAL GENOTOXIC EFFECTS OF ELF MAGNETIC FIELD
, 1995 Andrea Ferrara +3 more
openalex +1 more source
Cell Proliferation, EarlyView.Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao +8 more
wiley +1 more source