Results 41 to 50 of about 107,212 (246)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Development of high-throughput imaging-based single cell genotype-phenotype mapping platforms

, 2023
This thesis proposes a novel screening method for genotype-phenotype mapping that combines microfluidic chips with chemical or molecular biology assays, enabling accurate and high-throughput time-lapse phenotype-genotype mapping at the single-cell level.
Wan, Suyang
core  

On the mapping of QTL by regression of phenotype on marker-type [PDF]

, 1996
We consider the properties of the regression of phenotype on marker-type in Fz and backcross populations. We show that this regression provides exactly the same information about the location and effect of QTL as conventional regression mapping.
Visscher, PM, Whittaker, J. C., Whittaker, JC, J C Whittaker, Visscher, P. M., Thompson, R, P M Visscher, Thompson, R., R Thompson   +8 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The DU map: a visualization to gain insights into genotype-phenotype mapping and diversity

, 2017
The relation between diversity and genotype to phenotype mapping has been the focus of several studies. In those Evolutionary Algorithms (EAs) where the genotype is a sequence of symbols, the contribution of each of those symbols in determining the ...
Eric Medvet, MEDVET, Eric, Tea Tušar, Tušar, Tea   +3 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Domain-independent genotype to phenotype mapping through XML rules [PDF]

, 2010
This paper discusses an innovative approach to mapping Genotypes to Phenotypes through XML rules. Specifically, it concentrates on the mapping process using two very different domains – Regular Expressions (REs) and Software Program Statements. The paper
Chris J. Hinde (7167710), R.G. Stone (7167953), Daniela Xhemali (7168856)   +2 more
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Bridging scales in cancer progression: Mapping genotype to phenotype using neural networks

, 2014
In this review we summarise our recent efforts in trying to understand the role of heterogeneity in cancer progression by using neural networks to characterise different aspects of the mapping from a cancer cells genotype and environment to its phenotype.
Gerlee, Philip, Anderson, Alexander, Eunjung Kim, Kim, Eunjung, Philip Gerlee, Gerlee, Philip,, Er R. A. Anderson   +6 more
core   +1 more source