Results 21 to 30 of about 107,212 (246)

A condition for the genotype-phenotype mapping: Causality

, 1997
The appropriate choice of the genotype-phenotype mapping in combination with the mutation operator is important for a successful evolutionary search process. We suggest a measure to quantify the quality of this combination by addressing the question whether the relation among distances is carried over from one space to the other. Search processes which
Bernhard Sendhoff, Martin Kreutz, Werner von Seelen   +2 more
openaire   +2 more sources

Linking Genotype and Phenotype of Saccharomyces cerevisiae Strains Reveals Metabolic Engineering Targets and Leads to Triterpene Hyper-Producers [PDF]

, 2011
Background: Metabolic engineering is an attractive approach in order to improve the microbial production of drugs. Triterpenes is a chemically diverse class of compounds and many among them are of interest from a human health perspective.
Otero, Jose M., Otero, JM, Koetter, P, Jens Nielsen, Semba, Saori, Tetsuo Kushiro, Karina M Madsen, Nielsen, Jens B, Ebizuka, Yutaka, Jose M. Otero, Kötter, Peter, Gupta D. B. R. K. Udatha, Udatha, Gupta D. B. R. K., Semba, S, Yutaka Ebizuka, Otero Jose M., Jose M Otero, Nielsen, Jens, Panagiotou, Gianni, Panagiotou Gianni, Nielsen, J, Panagiotou, G, Gianni Panagiotou, Madsen Karina M., Udatha Gupta D. B. R. K., Semba Saori, Udatha, Gupta, Madsen, KM, Ebizuka, Y, Madsen, Karina Marie, Madsen, Karina M., Karina M. Madsen, Saori Semba, Udatha, GDBRK, Koetter Peter, Otero, Jos\ue9 Manuel, Otero Romero, José Manuel, Kushiro Tetsuo, Gupta D B R K Udatha, Ebizuka Yutaka, Kushiro, Tetsuo, Koetter, Peter, Kushiro, T, Udatha, D.B.R.K. Gupta, Nielsen Jens, Nielsen, Jens B., Peter Koetter   +46 more
core   +1 more source

Genotype-phenotype map characteristics of an in silico heart cell [PDF]

Frontiers in Physiology, 2011
Understanding the causal chain from genotypic to phenotypic variation is a tremendous challenge with huge implications for personalized medicine. Here we argue that linking computational physiology to genetic concepts, methodology, and data provides a new framework for this endeavor. We exemplify this causally cohesive genotype-phenotype (cGP) modeling
Jon Olav eVik, Arne Bjørke Gjuvsland, Liren eLi, Kristin eTøndel, Steven eNiederer, Nicolas eSmith, Nicolas eSmith, Peter eHunter, Stig William Omholt   +8 more
openaire   +4 more sources

Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients [PDF]

, 2003
The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn's disease represents an important step towards the delineation of the immuno-pathogenesis of inflammatory bowel disease.
Folwaczny, Christian, Török, H. P., Lohse, P., Glas, J.   +3 more
core   +1 more source

The genotype-phenotype map of an evolving digital organism

PLOS Computational Biology, 2017
To understand how evolving systems bring forth novel and useful phenotypes, it is essential to understand the relationship between genotypic and phenotypic change. Artificial evolving systems can help us understand whether the genotype-phenotype maps of natural evolving systems are highly unusual, and it may help create evolvable artificial systems ...
Miguel A. Fortuna, Luis Zaman, Charles Ofria, Andreas Wagner   +3 more
openaire   +6 more sources

Studying the Evolvability of of Self-Encoding Genotype-Phenotype Maps [PDF]

Artificial Life 14: Proceedings of the Fourteenth International Conference on the Synthesis and Simulation of Living Systems, 2014
We introduce a model of reproduction in which the genotypephenotype (G-P) map is able to evolve. In this model, Each organism implements a G-P map, determining how the organism is encoded in its genome. Crucially, it also determines how the G-P map itself is encoded. We call these maps 'self-encoding'.
Webb, Andrew M., Knowles, Joshua
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Genotype-to-phenotype maps.

, 2012
(A) An injective mapping illustrating one-to-one mapping of genotype to phenotype. (B) A non-injective mapping illustrating greater genetic complexity.
Timothy Galitski (3174), Ethan G. Thompson (152963)   +1 more
core   +1 more source

Comparative BAC-based mapping in the white-throated sparrow, a novel behavioral genomics model, using interspecies overgo hybridization [PDF]

, 2011
BACKGROUND The genomics era has produced an arsenal of resources from sequenced organisms allowing researchers to target species that do not have comparable mapping and sequence information.
Tuttle, Elaina M, Michael N Romanov, Jerry B Dodgson, Dodgson, Jerry B, Tuttle Elaina M, Elaina M Tuttle, Romanov, Michael N, Dodgson Jerry B, Romanov Michael N, Gonser Rusty A, Rusty A Gonser, Gonser, Rusty A   +11 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source