Results 11 to 20 of about 107,212 (246)
Monotonicity is a key feature of genotype-phenotype maps [PDF]
Frontiers in Genetics, 2013 It was recently shown that monotone gene action, i.e., order-preservation between allele content and corresponding genotypic values in the mapping from genotypes to phenotypes, is a prerequisite for achieving a predictable parent-offspring relationship across the whole allele frequency spectrum. Here we test the consequential prediction that the design
Arne Bjørke Gjuvsland +4 more
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Genotype-phenotype mapping in dynamic environments with grammatical evolution [PDF]
Proceedings of the 13th annual conference companion on Genetic and evolutionary computation, 2011 The application of a genotype-phenotype mapping in Evolutionary Computation is not a new idea, however, how this mapping process is interpreted, and implemented varies wildly. In the majority of cases a very simple abstraction of the biological genotype-phenotype mapping is used, but as our understanding of this process increases, the deficiencies in ...
David Fagan, Fagan, David
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Genotype-phenotype mapping with polyominos made from DNA origami tiles. [PDF]
Biophys J, 2022 The correlation between genetic information and characteristics of a living cell-its genotype and its phenotype-constitutes the basis of genetics. Here, we experimentally realize a primitive form of genotype-phenotype mapping with DNA origami.
Dreher Y +6 more
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Model genotype–phenotype mappings and the algorithmic structure of evolution [PDF]
Journal of The Royal Society Interface, 2019 Cancers are complex dynamic systems that undergo evolution and selection. Personalized medicine approaches in the clinic increasingly rely on predictions of tumour response to one or more therapies; these predictions are complicated by the inevitable evolution of the tumour.
Nichol, D +3 more
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Structural properties of genotype–phenotype maps [PDF]
Journal of The Royal Society Interface, 2017 The map between genotype and phenotype is fundamental to biology. Biological information is stored and passed on in the form of genotypes, and expressed in the form of phenotypes. A growing body of literature has examined a wide range of genotype–phenotype (GP) maps and has established a number of properties that appear to be shared by many GP maps ...
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Genetic association mapping via evolution-based clustering of haplotypes. [PDF]
, 2007 Multilocus analysis of single nucleotide polymorphism haplotypes is a promising approach to dissecting the genetic basis of complex diseases. We propose a coalescent-based model for association mapping that potentially increases the power to detect ...
Ioanna Tachmazidou +9 more
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Constraint Handling in Genotype to Phenotype Mapping and Genetic Operators for Project Staffing [PDF]
, 2020 Project staffing in many organisations involves the assignment of people to multiple projects while satisfying multiple constraints. The use of a genetic algorithm with constraint handling performed during a genotype to phenotype mapping process ...
Bentley, P +5 more
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Chromatin regulators shape the genotype–phenotype map
Molecular Systems Biology, 2010 Mol Syst Biol. 6: 434 Whereas mechanistic developmental biology and evolutionary genetics largely proceeded independently from each other throughout most of the twentieth century, new discoveries and technologies have made it possible to revisit longstanding questions of how molecular mechanisms generate the phenotypic effects of alternative alleles ...
Landry, Christian R, Rifkin, Scott A
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Network properties of genotype-phenotype mappings [PDF]
, 2016 Peer ...
Fuente Marañón, Rebeca de la
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A genetic algorithm with a multi-layered genotype-phenotype mapping
, 2018 In this paper we investigate the introduction of a multiple-layer genotype-phenotype mapping to a Genetic Algorithm (GA) which attempts to mimic more closely, the effects of nature.
O'Riordan, Colm +2 more
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