Results 11 to 20 of about 143,667 (204)

GPCards: An integrated database of genotype–phenotype correlations in human genetic diseases

Computational and Structural Biotechnology Journal, 2021
Genotype–phenotype correlations are the basis of precision medicine of human genetic diseases. However, it remains a challenge for clinicians and researchers to conveniently access detailed individual-level clinical phenotypic features of patients with ...
Bin Li, Zheng Wang, Qian Chen, Kuokuo Li, Xiaomeng Wang, Yijing Wang, Qian Zeng, Ying Han, Bin Lu, Yuwen Zhao, Rui Zhang, Li Jiang, Hongxu Pan, Tengfei Luo, Yi Zhang, Zhenghuan Fang, Xuewen Xiao, Xun Zhou, Rui Wang, Lu Zhou, Yige Wang, Zhenhua Yuan, Lu Xia, Jifeng Guo, Beisha Tang, Kun Xia, Guihu Zhao, Jinchen Li   +27 more
doaj   +1 more source

Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast

eLife, 2022
Mapping the genetic basis of complex traits is critical to uncovering the biological mechanisms that underlie disease and other phenotypes. Genome-wide association studies (GWAS) in humans and quantitative trait locus (QTL) mapping in model organisms can
Alex N Nguyen Ba, Katherine R Lawrence, Artur Rego-Costa, Shreyas Gopalakrishnan, Daniel Temko, Franziska Michor, Michael M Desai   +6 more
doaj   +1 more source

Deep mutational scanning: A versatile tool in systematically mapping genotypes to phenotypes

Frontiers in Genetics, 2023
Unveiling how genetic variations lead to phenotypic variations is one of the key questions in evolutionary biology, genetics, and biomedical research.
Huijin Wei, Xianghua Li, Xianghua Li, Xianghua Li, Xianghua Li   +4 more
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Monotonicity is a key feature of genotype-phenotype maps

Frontiers in Genetics, 2013
It was recently shown that monotone gene action, i.e. order-preservation between allele content and corresponding genotypic values in the mapping from genotypes to phenotypes, is a prerequisite for achieving a predictable parent-offspring relationship ...
Arne Bjørke Gjuvsland, Yunpeng eWang, Erik ePlahte, Stig W Omholt, Stig W Omholt   +4 more
doaj   +1 more source

Genotype-Phenotype Mapping for Applied Evolutionary Multi-Objective and Multi-Physics Topology Optimization

Applied Mechanics, 2022
We present a multi-objective topology optimization method based on the Non-Sorting Genetic Algorithm II (NSGA-II). The presented approach is a tool for early-stage engineering applications capable of providing insights into the complex relationship ...
Felix Schleifer, Kevin Deese
doaj   +1 more source

Linking microbial communities to ecosystem functions: what we can learn from genotype-phenotype mapping in organisms

bioRxiv, 2019
Microorganisms mediate many important ecosystem functions, yet it remains unclear to what extent microbial diversity or community composition is important for determining the rates of ecosystem-scale functions.
Andrew H. Morris, Kyle M. Meyer, B. Bohannan   +2 more
semanticscholar   +1 more source

Comprehensive analysis of gene regulatory dynamics, fitness landscape, and population evolution during sexual reproduction

New Journal of Physics, 2022
The fitness landscape is a critical concept in biophysics, evolutionary biology, and genetics that depicts fitness in the genotype space and visualizes the relationship between genotype and fitness.
Kenji Okubo, Kunihiko Kaneko
doaj   +1 more source

Genotype-phenotype correlation and description of two novel mutations in Iranian patients with glycogen storage disease 1b (GSD1b)

Orphanet Journal of Rare Diseases, 2020
Background Glycogen storage disease (GSD) is a rare inborn error of the synthesis or degradation of glycogen metabolism. GSD1, the most common type of GSD, is categorized into GSD1a and GSD1b which caused by the deficiency of glucose-6-phosphatase (G6PC)
Maryam Eghbali, Maryam Abiri, Saeed Talebi, Zahra Noroozi, Marjan Shakiba, Parastoo Rostami, Hosein Alimadadi, Mehri Najafi, Fatemeh Yazarlou, Ali Rabbani, Mohammad Hossein Modarressi   +10 more
doaj   +1 more source

Neutrality and robustness in evo-devo: emergence of lateral inhibition. [PDF]

PLoS Computational Biology, 2008
Embryonic development is defined by the hierarchical dynamical process that translates genetic information (genotype) into a spatial gene expression pattern (phenotype) providing the positional information for the correct unfolding of the organism.
Andreea Munteanu, Ricard V Solé
doaj   +1 more source

The role of genome and gene regulatory network canalization in the evolution of multi-trait polymorphisms and sympatric speciation

BMC Evolutionary Biology, 2009
Background Sexual reproduction has classically been considered as a barrier to the buildup of discrete phenotypic differentiation. This notion has been confirmed by models of sympatric speciation in which a fixed genetic architecture and a linear ...
Hogeweg Paulien, ten Tusscher Kirsten HWJ   +1 more
doaj   +1 more source