Results 1 to 10 of about 92,892 (112)
Genotype-phenotype mapping in a post-GWAS world. [PDF]
Trends Genet, 2012 Understanding how metabolic reactions, cell signaling, and developmental pathways translate the genome of an organism into its phenotype is a grand challenge in biology. Genome-wide association studies (GWAS) statistically connect genotypes to phenotypes, without any recourse to known molecular interactions, whereas a molecular biology approach ...
Nuzhdin SV, Friesen ML, McIntyre LM.
europepmc +4 more sources
Genotype–phenotype mapping and the end of the ‘genes as blueprint’ metaphor [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2010 In a now classic paper published in 1991, Alberch introduced the concept of genotype–phenotype (G→P) mapping to provide a framework for a more sophisticated discussion of the integration between genetics and developmental biology that was then available.
Massimo Pigliucci
exaly +3 more sources
Inferring genotype-phenotype maps using attention models. [PDF]
PNAS NexusPredicting phenotype from genotype is a central challenge in genetics. Traditional approaches in quantitative genetics typically analyze this problem using methods based on linear regression. These methods generally assume that the genetic architecture of complex traits can be parameterized in terms of an additive model, where the effects of loci are ...
Rijal K +5 more
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The architecture of an empirical genotype-phenotype map [PDF]
Evolution; international journal of organic evolution, 2018 ISSN:0014 ...
Aguilar‐Rodríguez J +4 more
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Learning Monotonic Genotype-Phenotype Maps [PDF]
Statistical Applications in Genetics and Molecular Biology, 2011 Evolutionary escape of pathogens from the selective pressure of immune responses and from medical interventions is driven by the accumulation of mutations. We introduce a statistical model for jointly estimating the dynamics and dependencies among genetic alterations and the associated phenotypic changes.
Beerenwinkel, Niko +2 more
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A Comparison of Genotype-Phenotype Maps for RNA and Proteins [PDF]
Biophysical Journal, 2012 The relationship between the genotype (sequence) and the phenotype (structure) of macromolecules affects their ability to evolve new structures and functions. We here compare the genotype space organization of proteins and RNA molecules to identify differences that may affect this ability.
Ferrada Evandro, Wagner Andreas
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Estimation of Genetic Effects and Genotype-Phenotype Maps [PDF]
Evolutionary Bioinformatics, 2008 Determining the genetic architecture of complex traits is a necessary step to understand phenotypic changes in natural, experimental and domestic populations. However, this is still a major challenge for modern genetics, since the estimation of genetic effects tends to be complicated by genetic interactions, which lead to changes in the effect of ...
Arnaud Le Rouzic +1 more
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Bridging the genotype-phenotype mapping for digital FPGAs [PDF]
Proceedings Third NASA/DoD Workshop on Evolvable Hardware. EH-2001, 2002 To solve the genome complexity issue and enable evolution of large complex circuits, the need to move away from a one-to-one genotype/phenotype mapping is becoming generally accepted. This involves development of new forms of representation with features such as growth.
Pauline C. Haddow, Gunnar Tufte
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Exploring the evolution of Genotype Phenotype Mappings [PDF]
2017 IEEE Congress on Evolutionary Computation (CEC), 2017 This paper investigates the evolution of two types of simple Genotype Phenotype Mappings (GPMs): a many-to-one mapping and a one-to-many mapping. Both GPMs are under genetic control. For both types of mappings different Regions Of Maximum Adaptability (ROMAs) are found. These ROMAs are the regions - in a paramterized space of GPMs - evolution leads to.
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