Results 1 to 10 of about 143,667 (204)
Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping
Nature Communications, 2019 Genome-scale engineering is an indispensable tool to understand genome functions due to our limited knowledge of cellular networks. Unfortunately, most existing methods for genome-wide genotype–phenotype mapping are limited to a single mode of genomic ...
J. Lian +4 more
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An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping
Cell, 2020 Gastroenteropancreatic (GEP) neuroendocrine neoplasm (NEN) that consists of neuroendocrine tumor and neuroendocrine carcinoma (NEC) is a lethal but under-investigated disease owing to its rarity.
Kazuhiro Togasaki +2 more
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On the incongruence of genotype-phenotype and fitness landscapes
PLoS Computational Biology, 2022 The mapping from genotype to phenotype to fitness typically involves multiple nonlinearities that can transform the effects of mutations. For example, mutations may contribute additively to a phenotype, but their effects on fitness may combine non ...
Malvika Srivastava, Joshua L. Payne
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Evolution of genetic redundancy: the relevance of complexity in genotype–phenotype mapping [PDF]
New Journal of Physics, 2013 Despite its ubiquity among organisms, genetic redundancy is presumed to reduce total population fitness and is therefore unlikely to evolve. This study evaluates an evolutionary model with high-dimensional genotype–phenotype mapping (GPM) by applying a ...
Nen Saito, S. Ishihara, K. Kaneko
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Nature CommunicationsSubclonal copy number alterations are a prevalent feature in tumors with high chromosomal instability and result in heterogeneous cancer cell populations with distinct phenotypes.
Hongyu Shi +5 more
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Genotype–phenotype mapping and the end of the ‘genes as blueprint’ metaphor
Philosophical Transactions of the Royal Society B: Biological Sciences, 2010 Massimo Pigliucci
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In silico candidate variant and gene identification using inbred mouse strains [PDF]
PeerJ, 2021 Mice are the most widely used animal model to study genotype to phenotype relationships. Inbred mice are genetically identical, which eliminates genetic heterogeneity and makes them particularly useful for genetic studies.
Matthias Munz +4 more
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Cell Reports, 2023 Human lung cancer is a constellation of tumors with various histological and molecular properties. To build a preclinical platform that covers this broad disease spectrum, we obtained lung cancer specimens from multiple sources, including sputum and ...
T. Ebisudani +27 more
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APPROACHES TO ANALYSIS OF GENOTYPE AND PHENOTYPE RELATION WITH QTL METHODS [PDF]
Научно-технический вестник информационных технологий, механики и оптики, 2018 The paper describes methods of QTL-analysis in the research of the genotype influence. QTL-analysis is a statistical method that connects phenotypic data with genotype, enables the determination of the exact localization and gene influence power. The QTL
Furta E.Yu., Shabalina I.M.
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Genetic Correlations Greatly Increase Mutational Robustness and Can Both Reduce and Enhance Evolvability. [PDF]
PLoS Computational Biology, 2016 Mutational neighbourhoods in genotype-phenotype (GP) maps are widely believed to be more likely to share characteristics than expected from random chance. Such genetic correlations should strongly influence evolutionary dynamics.
Sam F Greenbury +3 more
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