Results 1 to 10 of about 508,880 (140)
Gene regulatory networks elucidating huanglongbing disease mechanisms. [PDF]
PLoS ONE, 2013 Next-generation sequencing was exploited to gain deeper insight into the response to infection by Candidatus liberibacter asiaticus (CaLas), especially the immune disregulation and metabolic dysfunction caused by source-sink disruption.
Federico Martinelli +8 more
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Integrated module and gene-specific regulatory inference implicates upstream signaling networks. [PDF]
PLoS Computational Biology, 2013 Regulatory networks that control gene expression are important in diverse biological contexts including stress response and development. Each gene's regulatory program is determined by module-level regulation (e.g.
Sushmita Roy +5 more
doaj +3 more sources
Frontiers in Cell and Developmental Biology, 2014 In recent years gene regulatory networks (GRNs) have attracted a lot of interest and many methods have been introduced for their statistical inference from gene expression data. However, despite their popularity, GRNs are widely misunderstood.
Frank eEmmert-Streib +2 more
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Glucocorticoid receptor-dependent gene regulatory networks. [PDF]
PLoS Genetics, 2005 While the molecular mechanisms of glucocorticoid regulation of transcription have been studied in detail, the global networks regulated by the glucocorticoid receptor (GR) remain unknown.
Phillip Phuc Le +6 more
doaj +2 more sources
Quantum gene regulatory networks
npj Quantum Information, 2023 In this work, we present a quantum circuit model for inferring gene regulatory networks (GRNs) from single-cell transcriptomic data. The model employs qubit entanglement to simulate interactions between genes, resulting in competitive performance and ...
Cristhian Roman-Vicharra, James J. Cai
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The role of master regulators in gene regulatory networks [PDF]
Papers in Physics, 2015 Gene regulatory networks present a wide variety of dynamical responses to intrinsic and extrinsic perturbations. Arguably, one of the most important of such coordinated responses is the one of amplification cascades, in which activation of a few key ...
Enrique Hernández Lemus +3 more
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Evolving robust gene regulatory networks. [PDF]
PLoS ONE, 2015 Design and implementation of robust network modules is essential for construction of complex biological systems through hierarchical assembly of 'parts' and 'devices'.
Nasimul Noman +3 more
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Inferring gene regulatory network from single-cell transcriptomes with graph autoencoder model.
PLoS Genetics, 2023 The gene regulatory structure of cells involves not only the regulatory relationship between two genes, but also the cooperative associations of multiple genes.
Jiacheng Wang, Yaojia Chen, Quan Zou
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Discovering study-specific gene regulatory networks. [PDF]
PLoS ONE, 2014 Microarrays are commonly used in biology because of their ability to simultaneously measure thousands of genes under different conditions. Due to their structure, typically containing a high amount of variables but far fewer samples, scalable network ...
Valeria Bo +5 more
doaj +1 more source
The Inferred Cardiogenic Gene Regulatory Network in the Mammalian Heart [PDF]
, 2013 Cardiac development is a complex, multiscale process encompassing cell fate adoption, differentiation and morphogenesis. To elucidate pathways underlying this process, a recently developed algorithm to reverse engineer gene regulatory networks was ...
Bazil, Jason +6 more
core +8 more sources