Results 11 to 20 of about 509,029 (282)
Evolution of evolvability in gene regulatory networks. [PDF]
PLoS Computational Biology, 2008 Gene regulatory networks are perhaps the most important organizational level in the cell where signals from the cell state and the outside environment are integrated in terms of activation and inhibition of genes.
Anton Crombach, Paulien Hogeweg
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Fan-out in gene regulatory networks [PDF]
Journal of Biological Engineering, 2010 Background In synthetic biology, gene regulatory circuits are often constructed by combining smaller circuit components. Connections between components are achieved by transcription factors acting on promoters. If the individual components behave as true
Sauro Herbert M, Kim Kyung H
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Dynamical Criticality in Gene Regulatory Networks [PDF]
Complexity, 2018 A well-known hypothesis, with far-reaching implications, is that biological evolution should preferentially lead to states that are dynamically critical.
Marco Villani +3 more
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Chaotic motifs in gene regulatory networks. [PDF]
PLoS ONE, 2012 Chaos should occur often in gene regulatory networks (GRNs) which have been widely described by nonlinear coupled ordinary differential equations, if their dimensions are no less than 3. It is therefore puzzling that chaos has never been reported in GRNs
Zhaoyang Zhang +5 more
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Automated Identification of Core Regulatory Genes in Human Gene Regulatory Networks.
PLoS Computational Biology, 2015 Human gene regulatory networks (GRN) can be difficult to interpret due to a tangle of edges interconnecting thousands of genes. We constructed a general human GRN from extensive transcription factor and microRNA target data obtained from public databases.
Vipin Narang +6 more
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Gene regulatory networks [PDF]
Proceedings of the National Academy of Sciences, 2005 The Special Feature on gene regulatory networks in this issue of PNAS highlights an emerging field in the biosciences: gene regulatory networks that control animal development. The complex control systems underlying development have probably been evolving for more than a billion years.
Eric, Davidson, Michael, Levin
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Logic of gene regulatory networks [PDF]
Current Opinion in Biotechnology, 2007 Regulatory networks of transcription factors and signaling molecules lie at the heart of development. Their architecture implements logic functions whose execution propels cells from one regulatory state to the next, thus driving development forward.
Materna, Stefan C., Davidson, Eric H.
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Synchrony in Gene Regulatory Networks
Physica D: Nonlinear phenomena, 2021 We consider two mathematical dynamical models of gene regulatory networks (GRNs) and obtain results on robust synchronization on these dynamical models based on the existing theoretical results in the coupled cell network formalism. We also explore the concepts of quotient networks and network lifting in the context of GRNs which are related to the ...
Aguiar, Manuela A. D. +2 more
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Introduction to gene regulatory networks [PDF]
Proceedings of the Genetic and Evolutionary Computation Conference Companion, 2015 Gene regulatory networks are a central mechanism in the regulation of gene expression in all living organisms? cells. Their functioning is nowadays very well understood: they are based on the production of proteins enhanced or inhibited by other proteins inside and outside the cells. This produces a complex dynamics with which, with the exact same DNA,
Sylvain Cussat-Blanc, Wolfgang Banzhaf
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Gene-centered regulatory networks [PDF]
Briefings in Functional Genomics, 2009 Differential gene expression plays a critical role in the development and physiology of multicellular organisms. At a 'systems level' (e.g. at the level of a tissue, organ or whole organism), this process can be studied using gene regulatory network (GRN) models that capture physical and regulatory interactions between genes and their regulators.
Arda, H. Efsun, Walhout, Albertha J M
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