Results 21 to 30 of about 509,029 (282)
Structure learning for gene regulatory networks.
PLoS Computational Biology, 2023 Inference of biological network structures is often performed on high-dimensional data, yet is hindered by the limited sample size of high throughput "omics" data typically available. To overcome this challenge, often referred to as the "small n, large p
Anthony Federico +3 more
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Gene Self-Expressive Networks as a Generalization-Aware Tool to Model Gene Regulatory Networks
Biomolecules, 2023 Self-expressiveness is a mathematical property that aims at characterizing the relationship between instances in a dataset. This property has been applied widely and successfully in computer-vision tasks, time-series analysis, and to infer underlying ...
Sergio Peignier, Federica Calevro
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Gene regulatory networks for development [PDF]
Proceedings of the National Academy of Sciences, 2005 The genomic program for development operates primarily by the regulated expression of genes encoding transcription factors and components of cell signaling pathways. This program is executed by cis-regulatory DNAs (e.g., enhancers and silencers) that control gene expression.
Levine, Michael, Davidson, Eric H.
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Gradient descent optimization in gene regulatory pathways. [PDF]
PLoS ONE, 2010 BACKGROUND: Gene Regulatory Networks (GRNs) have become a major focus of interest in recent years. Elucidating the architecture and dynamics of large scale gene regulatory networks is an important goal in systems biology.
Mouli Das +2 more
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Supervised Learning of Gene Regulatory Networks [PDF]
Current Protocols in Plant Biology, 2020 AbstractIdentifying the entirety of gene regulatory interactions in a biological system offers the possibility to determine the key molecular factors that affect important traits on the level of cells, tissues, and whole organisms. Despite the development of experimental approaches and technologies for identification of direct binding of transcription ...
Razaghi-Moghadam, Zahra +1 more
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Stochastic models and numerical algorithms for a class of regulatory gene networks [PDF]
, 2008 Regulatory gene networks contain generic modules like those involving feedback loops, which are essential for the regulation of many biological functions.
Fournier, Thomas +5 more
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Artificial Gene Regulatory Networks—A Review [PDF]
Artificial Life, 2019 In nature, gene regulatory networks are a key mediator between the information stored in the DNA of living organisms (their genotype) and the structural and behavioral expression this finds in their bodies, surviving in the world (their phenotype). They integrate environmental signals, steer development, buffer stochasticity, and allow evolution to ...
Cussat-Blanc, Sylvain +2 more
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Dynamic Bayesian networks in molecular plant science: inferring gene regulatory networks from multiple gene expression time series [PDF]
, 2011 To understand the processes of growth and biomass production in plants, we ultimately need to elucidate the structure of the underlying regulatory networks at the molecular level.
Dondelinger, F., Husmeier, D., Lebre, S.
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Communications Biology, 2023 Single-cell RNA-seq analysis coupled with CRISPR-based perturbation has enabled the inference of gene regulatory networks with causal relationships.
Masato Ishikawa +12 more
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Time-delayed models of gene regulatory networks [PDF]
, 2015 We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternativemodelling approaches, we use a paradigmatic two-gene network to focus on the role played by time ...
Blyuss, K B +3 more
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