Results 21 to 30 of about 946,920 (339)
Glucocorticoid receptor-dependent gene regulatory networks. [PDF]
PLoS Genetics, 2005 While the molecular mechanisms of glucocorticoid regulation of transcription have been studied in detail, the global networks regulated by the glucocorticoid receptor (GR) remain unknown.
Phillip Phuc Le +6 more
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SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks
bioRxiv, 2022 SCENIC+ is a comprehensive toolbox for inferring and analyzing enhancer-driven gene regulatory networks using single-cell multiomic data. Joint profiling of chromatin accessibility and gene expression in individual cells provides an opportunity to ...
C. González-Blas +9 more
semanticscholar +1 more source
ARACNE: An Algorithm for the Reconstruction of Gene Regulatory Networks in a Mammalian Cellular Context [PDF]
BMC Bioinformatics, 2004 BackgroundElucidating gene regulatory networks is crucial for understanding normal cell physiology and complex pathologic phenotypes. Existing computational methods for the genome-wide "reverse engineering" of such networks have been successful only for ...
Adam A. Margolin +6 more
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Gene regulatory networks [PDF]
Proceedings of the National Academy of Sciences, 2005 The Special Feature on gene regulatory networks in this issue of PNAS highlights an emerging field in the biosciences: gene regulatory networks that control animal development. The complex control systems underlying development have probably been evolving for more than a billion years.
Eric, Davidson, Michael, Levin
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Brassinosteroid gene regulatory networks at cellular resolution in the Arabidopsis root
Science, 2023 Brassinosteroids are plant steroid hormones that regulate diverse processes, such as cell division and cell elongation, through gene regulatory networks that vary in space and time.
Trevor M. Nolan +17 more
semanticscholar +1 more source
The role of master regulators in gene regulatory networks [PDF]
Papers in Physics, 2015 Gene regulatory networks present a wide variety of dynamical responses to intrinsic and extrinsic perturbations. Arguably, one of the most important of such coordinated responses is the one of amplification cascades, in which activation of a few key ...
Enrique Hernández Lemus +3 more
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GRaNIE and GRaNPA: inference and evaluation of enhancer‐mediated gene regulatory networks
Molecular Systems Biology, 2023 Enhancers play a vital role in gene regulation and are critical in mediating the impact of noncoding genetic variants associated with complex traits. Enhancer activity is a cell‐type‐specific process regulated by transcription factors (TFs), epigenetic ...
Aryan Kamal +14 more
semanticscholar +1 more source
Evolving robust gene regulatory networks. [PDF]
PLoS ONE, 2015 Design and implementation of robust network modules is essential for construction of complex biological systems through hierarchical assembly of 'parts' and 'devices'.
Nasimul Noman +3 more
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Inferring gene regulatory network from single-cell transcriptomes with graph autoencoder model.
PLoS Genetics, 2023 The gene regulatory structure of cells involves not only the regulatory relationship between two genes, but also the cooperative associations of multiple genes.
Jiacheng Wang, Yaojia Chen, Quan Zou
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Logic of gene regulatory networks [PDF]
Current Opinion in Biotechnology, 2007 Regulatory networks of transcription factors and signaling molecules lie at the heart of development. Their architecture implements logic functions whose execution propels cells from one regulatory state to the next, thus driving development forward.
Materna, Stefan C., Davidson, Eric H.
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