Results 191 to 200 of about 1,614,514 (332)

Safety and Efficacy of Ombitasvir, Paritaprevir With Ritonavir ± Dasabuvir With or Without Ribavirin in Patients With Human Immunodeficiency Virus-1 and Hepatitis C Virus Genotype 1 or Genotype 4 Coinfection: TURQUOISE-I Part 2 [PDF]

, 2017
Jürgen K. Rockstroh, Chloe Orkin, Rolando M. Viani, David Wyles, Anne F. Luetkemeyer, Adriano Lazzarin, Ruth Soto-Malave, Mark Nelson, Sanjay Bhagani, Hartwig Klinker, Giuliano Rizzardini, Pierre‐Marie Girard, Cristina Tural, Nancy S. Shulman, Niloufar Mobashery, Yiran Hu, Linda Fredrick, Edward Tam, Roger Trinh, Edward Gane   +19 more
openalex   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Correlation Between <i>ALDH2</i> Gene Polymorphism and Coronary Artery Disease in Patients With Atrial Fibrillation. [PDF]

Cardiovasc Ther
Zheng B, Li M, Wang P, Lin J, Pei H, Liu H, Ye X.   +6 more
europepmc   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Natural Dyes and Antioxidant Compounds from Safflower (<i>Carthamus tinctorius</i> L.) Florets: The Effects of Genotype and Sowing Time. [PDF]

Plants (Basel)
Clemente C, Tavarini S, Antoni S, Zublena S, Angelini LG, Degano I.   +5 more
europepmc   +1 more source

Optimizing the production of true shallot seed by inducing flowering in various shallot genotypes

Cahyati Ramdhani, Awang Maharijaya, Sobir Sobir, Arya Widura Ritonga   +3 more
openalex   +2 more sources

Bovine Viral Diarrhea Virus Cytopathic and Noncytopathic Biotypes and Type 1 and 2 Genotypes in Diagnostic Laboratory Accessions: Clinical and Necropsy Samples from Cattle [PDF]

, 2000
Robert W. Fulton, Jeremiah T. Saliki, Anthony W. Confer, Lurinda J. Burge, Jean M. d’Offay, R. Gayman Helman, Steven R. Bolin, Julia F. Ridpath, Mark E. Payton   +8 more
openalex   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

DNA Methylation Fine-Tunes Light- and Hormone-Responsive Growth Plasticity in <i>Arabidopsis</i> Seedlings. [PDF]

Int J Mol Sci
Talarico E, Greco E, Chiappetta A, Araniti F, Bruno L.   +4 more
europepmc   +1 more source

Using MZ Twins in Experimental Research to Test for the Presence of a Genotype-Environment Interaction Effect [PDF]

, 1990
Claude Bouchard, Louis Përusse, C. Leblanc   +2 more
openalex   +1 more source