Results 191 to 200 of about 2,216,855 (328)

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Genetic characteristics of rotavirus a in Shenzhen and Zhuhai, China, 2020-2023. [PDF]

BMC Genomics
Hu M, Lin Y, Zhang R, Wang X, He Y, Huang H, Wang B, Liu W, Li K, Fu J, Zhao X, Aimaiti B, Yang W, Song H, Ren H, Hu X.   +15 more
europepmc   +1 more source

Cervical cancer screening and HPV genotype distribution among asymptomatic patients of Karachi Pakistan [PDF]

, 1969
Mubeena Shahid
openalex   +1 more source

Intestinal Epithelial‐Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78‐mediated Endoplasmic Reticulum Stress

Advanced Science, EarlyView.
USP13 deficiency in intestinal epithelial cells aggravates DSS‐induced colitis by enhancing ER stress and apoptosis. USP13 interacts with GRP78 and reduces its K63‐linked ubiquitination to alleviate epithelial injury. Restoring USP13 expression or targeting the USP13‐GRP78 axis may represent a promising strategy for treating inflammatory bowel disease ...
Chenchen Qian, Chenghong Hu, Yong Xu, Wentao Xu, Zhe Wang, Wan Gan, Weiyang Tang, Lijiang Huang, Aleksandr V. Samorodov, Yi Wang   +9 more
wiley   +1 more source

Boceprevir for untreated chronic HCV genotype 1 infection.

New England Journal of Medicine, 2011
F. Poordad, J. McCone, B. Bacon, S. Bruno, Michael P. Manns, M. Sulkowski, I. Jacobson, K. Reddy, Z. Goodman, N. Boparai, M. Dinubile, V. Sniukiene, C. Brass, J. Albrecht, J. Bronowicki   +14 more
semanticscholar   +2 more sources

Training Schedule Affects Operant Responding Independent of Motivation in the Neuroligin-3 R451C Mouse Model of Autism. [PDF]

Genes Brain Behav
Dingwall R, May C, McDonald JA, Hill T, Brown R, Lawrence AJ, Hannan AJ, Burrows EL.   +7 more
europepmc   +1 more source

Effeots of High Temperature and Genotype on the Growth of Excised Roots of Arabidopsis Thaliana [PDF]

, 1968
TF Neales
openalex   +1 more source

Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection.

New England Journal of Medicine, 2014
N. Afdhal, S. Zeuzem, P. Kwo, M. Chojkier, N. Gitlin, M. Puoti, M. Romero‐Gomez, J. Zarski, K. Agarwal, P. Buggisch, G. Foster, N. Bräu, M. Buti, I. Jacobson, G. Subramanian, Xiao Ding, H. Mo, Jenny C. Yang, P. Pang, W. Symonds, J. Mchutchison, A. Muir, A. Mangia, P. Marcellin   +23 more
semanticscholar   +1 more source

The Evolutionary Trajectory and Prognostic Value of GITR+ Tregs Reprogramed by Tumor‐Intrinsic PD‐1/c‐MET Signaling in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), tumor‐intrinsic PD‐1 signaling activates the MET pathway, leading to the establishment of an immunosuppressive tumor microenvironment (TME). This MET‐driven signaling cascade promotes the selective accumulation of GITR+ regulatory T cells (Tregs), a highly immunosuppressive subset.
Jiande Han, Hanlin Yin, Taochen He, Junyi He, Zhenlai Jiang, Qiangda Chen, Zhihang Xu, Yuqi Xie, Yaolin Xu, Haibo Wang, Wenquan Wang, Wenchuan Wu, Yun Jin, Wenhui Lou, Jun Yu, Ning Pu, Liang Liu   +16 more
wiley   +1 more source

Genotype-Environment Interactions in Broiler Stocks of Chickens

, 1968
L.D. Tindell, C.H. Moore, N.R. Gyles, William A. Johnson, L.J. Dreesen, Gerald A. Martin, P.B. Siegel   +6 more
openalex   +2 more sources