Results 201 to 210 of about 2,216,855 (328)

CYP2C19-Guided Voriconazole Therapy: A Precision Medicine Approach to Mitigate Adverse Effects in Japanese Patients. [PDF]

open access: yesClin Transl Sci
Katada Y   +19 more
europepmc   +1 more source

Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis

open access: yesJAMA Neurology, 2017
S. Neu   +23 more
semanticscholar   +1 more source

Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway

open access: yesAdvanced Science, EarlyView.
A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen   +16 more
wiley   +1 more source

Advanced Microfluidics for Single Cell‐Based Cancer Research

open access: yesAdvanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro   +10 more
wiley   +1 more source

Personalized Genotype-Based Approach for Treatment of Phenylketonuria. [PDF]

open access: yesJ Inherit Metab Dis
Gundorova P   +8 more
europepmc   +1 more source

METTL3/ALKBH5‐Mediated N6‐Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3‐TASL‐IRF5 Signaling Axis in Psoriasis

open access: yesAdvanced Science, EarlyView.
m6A modification stabilizes Slc15a3 mRNA in macrophages, activating the SLC15A3‐TASL‐IRF5 axis and promoting psoriatic inflammation. Abstract Impaired N6‐methyladenosine (m6A) modification has been implicated in regulating various inflammatory diseases, but its role in psoriasis remains unclear.
Tao Huang   +13 more
wiley   +1 more source

The relationship between riboflavin and hypertension with MTHFR C677T in older adults in northern China: a case-control study. [PDF]

open access: yesAsia Pac J Clin Nutr
Zhang L   +9 more
europepmc   +1 more source

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