Results 211 to 220 of about 1,614,514 (332)

Apolipoprotein E4 in Alzheimer's Disease: Role in Pathology, Lipid Metabolism, and Drug Treatment. [PDF]

Int J Mol Sci
Al-Ghraiybah NF, Alkhalifa AE, Itokazu Y, Farr TO, Perez NC, Ali H, Kaddoumi A.   +6 more
europepmc   +1 more source

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

Nature Genetics, 2012
Bryan N. Howie, C. Fuchsberger, M. Stephens, J. Marchini, G. Abecasis   +4 more
semanticscholar   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Genetic landscape of Italian SRLV: insights from passive surveillance-based phylogenetic analysis. [PDF]

Front Microbiol
Gobbi P, Tassoni L, Tinelli E, Scoccia E, Mrabet S, Orrico M, Righi C, Maresca C, D'Avino N, Passamonti F, Giammarioli M, Feliziani F, Beato MS.   +12 more
europepmc   +1 more source

Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants

Advanced Science, EarlyView.
In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao, Yanbin Li, Shengqi Zhang, Yilin He, Zhiqi Liu, Juan Wang, Jingmin Hua, Jinyu Chen, Junru Zhong, Huan Zhong, Yiji Xia, Yong Cui, Liwen Jiang   +12 more
wiley   +1 more source

The interplay of APOE and APOA1 gene polymorphisms modulates the risk of type 2 diabetes mellitus in an obese population: a case-control study". [PDF]

Eur J Med Res
Usama N, Ahmed AE, Mekheimer S, Elhadidy K, Farid M.   +4 more
europepmc   +1 more source

Genotype and Phenotype at Baseline and at Failure in Human Immunodeficiency Virus–Infected Antiretroviral‐Naive Patients in a Randomized Trial Comparing Zidovudine and Lamivudine plus Nelfinavir or Nevirapine [PDF]

, 2003
Elena Ferrer, Daniel Podzamczer, Mireia Arnedo, Emilio Fumero, Paula McKenna, Alex R. Rinehart, José L. Pérez, María Jesús Barberà, Tomàs Pumarola, José M. Gatell, Francisco Gudiol, Combine Study Team   +11 more
openalex   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Regression approaches for modeling genotype-environment interaction and making predictions into unseen environments. [PDF]

Theor Appl Genet
Hrachov M, Piepho HP, Rahman NMF, Malik WA.   +3 more
europepmc   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source