Results 251 to 260 of about 2,216,855 (328)

Highly genetically diverse variants of hepatitis C virus still predominate in Cameroon but with low frequency of mutations associated to resistance of NS5B polymerase-targeted antivirals. [PDF]

JAC Antimicrob Resist
Levoa Eteme F, Mafopa Goumkwa N, Otam AL, Lobe C, Yengo CK, Kowo M, Tchapda L, Pempeme I, Ngameleu WA, Engarimbi JE, Ndonku SA, Yannick DN, Awoumou PL, Kwizera MA, Oudou N, Okomo MCA, Fokunang CN, Luma HN, Torimiro JNE.   +18 more
europepmc   +1 more source

Haptoglobin genotype, haemoglobin and malaria in Gambian children [PDF]

, 2007
Atkinson, SH, Cox, SE, Doherty, C, Fulford, T, Ghattas, H, Kwiatkowski, D, Nweneka, CV, Prentice, A, Rockett, K   +8 more
core  

A Study on the Cell Layer Patterns of a Citrus Periclinal Chimera Reveals β‐Cryptoxanthin Regulation in Citrus Fruits

Advanced Science, EarlyView.
Researchers have identified a citrus chimera with distinctive tissue origins and carotenoid profiles. It is discovered that fruit tissues develop from all three cell layers but in different proportions. A key transcription factor, MYB107, regulates β‐cryptoxanthin production by directly activating carotenoid biosynthesis genes, explaining why some ...
Chi Zhang, Kaijie Zhu, Zhehui Zhang, Huiyu Ji, Qun Wu, Lin Zhang, Fuzhi Ke, Gang Wang, Min Zhang   +8 more
wiley   +1 more source

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

Advanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang, Yufang Bao, Lixing Xiao, Ningxia Zhang, Yunpeng Ren, Chunnan Liu, Yuting Chen, Han Han, Yunjian Pan, Lei Lv, Wei‐Xing Zong, Hongbin Ji, Changyou Zhan, Zefeng Wang, Haiquan Chen, Yongbo Wang   +19 more
wiley   +1 more source

Podocyte RIPK3 Deletion Improves Diabetic Kidney Disease by Attenuating NF‐κB p65 Driven Inflammation

Advanced Science, EarlyView.
Prevention and treatment of diabetic kidney disease (DKD) have become a major global public health challenge. This study shed new light on the underlying pathogenic mechanisms of podocyte injury in DKD and highlights the therapeutic potential of mitigating podocyte injury through inhibition of the RIPK3/NF‐κB p65‐mediated inflammatory response as a ...
Lu'an Li, Jiaying Li, Ruizhao Li, Xingchen Zhao, Yuanhan Chen, Yating Cai, Yan Yang, Weiteng Wang, Siqi Zheng, Li Zhang, Xinling Liang   +10 more
wiley   +1 more source

Uncovering rain-fed resilience power of grass pea in Iran using AMMI, BLUP, and multi-trait stability parameters. [PDF]

Sci Rep
Maleki HH, Vaezi B, Pirooz R, Darvishzadeh R, Modareskia M, Dadashi S, Niedbała G.   +6 more
europepmc   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Genetic Risk of MASLD in Mongolians: Role of PNPLA3 and FTO SNPs. [PDF]

Curr Issues Mol Biol
Tsedendorj Y, Daramjav D, Enkhbat Y, Dondov G, Dashjamts G, Khayankhyarvaa E, Ganzorig AE, Ulziitsogt B, Badamjav T, Batsaikhan B, Avirmed S, Lonjid T.   +11 more
europepmc   +1 more source