Results 331 to 340 of about 2,122,472 (401)

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

Advanced Science, EarlyView.
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie, Shang‐Hui Ye, Yu‐Ting Yue, Bao‐Hong Shi, Jing‐Ping Xu, Lian‐Jie Li, Zheng‐Biao Zou, Matthew B. Greenblatt, Na Li, Xian‐Wen Yang, Ren Xu   +10 more
wiley   +1 more source

Genotype-phenotype correlation in multiple endocrine neoplasia type 1. [PDF]

JCI Insight
Worthy CC, Tora R, Uttarkar CN, Welch JM, Bliss L, Cochran C, Ninan A, Kumar S, Wank S, Auh S, Weinstein LS, Simonds WF, Agarwal SK, Blau JE, Jha S.   +14 more
europepmc   +1 more source

Genotype-Environment Interactions in Broiler Stocks of Chickens

, 1967
L.D. Tindell, C.H. Moore, N.R. Gyles, William A. Johnson, L.J. Dreesen, Gerald A. Martin, P.B. Siegel   +6 more
openalex   +1 more source

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

Investigation of Cryptosporidium spp. and Enterocytozoon bieneusi in free-ranged livestock on the southeastern Qinghai-Xizang Plateau, China. [PDF]

BMC Infect Dis
Peng X, Wang X, Jian J, Zuo Q, Liu H, Wang Y, Su Y, Cao J, Jiang B, Shen Y.   +9 more
europepmc   +1 more source

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development

Advanced Science, EarlyView.
The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao, Tianxiang Tang, Bowen Wang, Shengfei He, Yue Zhang, Li Dong, Bo Xu, Ying Liu, Ping Zhu, Rui Guo   +9 more
wiley   +1 more source

Electrocardiographic Discrimination of Long QT Syndrome Genotypes: A Comparative Analysis and Machine Learning Approach. [PDF]

Sensors (Basel)
Srutova M, Kremen V, Lhotska L.
europepmc   +1 more source

The Transcription Factor WFZP Interacts with the Chromatin Remodeler TaSYD to Regulate Root Architecture and Nitrogen Uptake Efficiency in Wheat

Advanced Science, EarlyView.
Root development and nitrogen uptake efficiency are vital for crop productivity. Du, Li, Jiang, et al. show that the wheat transcription factor WFZP and the chromatin remodeler TaSYD form a complex within the nucleus, thereby activating the expression of genes associated with root development and nitrate transporters, ultimately enhancing both root ...
Dejie Du, Zhaoju Li, Zihao Jiang, Jun Yuan, Xiangyu Zhang, Huanhuan Zhao, Lulu Tian, Yunjie Liu, Renhan Li, Fei He, Xiongtao Li, Wensheng Ke, Lingling Chai, Jie Liu, Mingming Xin, Yingyin Yao, Qixin Sun, Jiewen Xing, Zhongfu Ni   +18 more
wiley   +1 more source

<i>CYP3A5</i> Polymorphism in Circulating Tumor Cells Confers an Increased Disease-Free Survival in DLBCL Patients Treated with R-CHOP. [PDF]

Onco Targets Ther
Cerón Maldonado R, Martínez Tovar A, Ramos Peñafiel CO, De la Cruz Rosas A, García Laguna AI, Mendoza Salas I, Martínez Murillo C, Barranco Lampón GI, Montaño Figueroa EH, Jiménez-Morales S, Olarte Carrillo I.   +10 more
europepmc   +1 more source