Results 101 to 110 of about 9,640,965 (252)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Genotype-environment interaction in personality development:identical twins reared apart

, 1988
The focus of this study is to identify specific genotype-environment (GE) interactions as they contribute to individual differences in personality in later life.
Plomin, R, Pedersen, N L, Bergeman, C S, McClearn, G E, Friberg, L T   +4 more
core   +1 more source

Stability and adaptability of grain yield in quinoa genotypes in four locations of Iran

Frontiers in Plant Science
The genotype × environment interaction is one of the effective factors in identifying and introducing cultivars with stable grain yield in different environments. There are many statistical methods for estimating genotype × environment interaction, among
Vahid Jokarfard, Babak Rabiei, Ebrahim Souri Laki, Andreas Börner   +3 more
doaj   +1 more source

Underground Signals: The Ecological Power of Root Volatiles

Advanced Science, EarlyView.
Root volatiles mediate rhizosphere chemical communication, shaping interactions among plants, microbes, herbivores, and natural enemies. Their production, transport, and perception underpin ecological adaptation, multitrophic interactions, and plant resilience, offering opportunities for sustainable crop protection, resilient agroecosystems, and ...
Xueyao Cao, Nanli Song, François Verheggen, Meritxell Pérez‐Hedo, Andrea Clavijo McCormick, Antonino Cusumano, Arthur de Fouchier, Bing Wang, Chen‐Zhu Wang, Emmanuelle Jacquin‐Joly, Gary W. Felton, Geoff M. Gurr, Hao Guo, Jiancai Li, Jin Zhang, Li Chen, Manqun Wang, Michele Ricupero, Peng Han, Peng He, Qi Yan, Qingbo Tang, Qingsong Liu, Shiheng An, Xiangbo Kong, Xiaoling Sun, Xueming Ren, Yuanyuan Song, Yang Liu, Yanhui Guo, Yunhe Li, Xiao Sun   +31 more
wiley   +1 more source

GGE Bi Plot Analysis of Genotype X Environment Interaction and Grain Yield Stability of Bread Wheat (Triticum aestivum L.) Genotypes in Ethiopia [PDF]

, 2017
There is limitation of information on G x EI of bread wheat genotypes in Ethiopia. The study cried out with objectives to estimate Genotype x Environment interaction and stability of bread wheat genotypes in Ethiopia.
Bacha, Temesgen, Taddesse, Zerihun, Mehari, Muez   +2 more
core   +1 more source

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Genotype x environment interaction in cassava multi-environment trials via analytic factor.

PLoS ONE
The variability in genetic variance and covariance due to genotype × environment interaction (G×E) can hinder genotype selection accuracy, especially for complex traits.
Juraci Souza Sampaio Filho, Isadora Cristina Martins Oliveira, Maria Marta Pastina, Marcos de Souza Campos, Eder Jorge de Oliveira   +4 more
doaj   +1 more source

Efficiency of Factor Analysis-Based Selection Indices Under Varying Heritability and Trait-Environment Correlations

Agriculture
The main approach for improving multiple traits simultaneously is the selection index. The most widely used selection indices are those based on factor analysis, which overcome statistical limitations such as multicollinearity and the reliance on ...
Wanessa Alves Lima Paiva, Brenda Vieira de Oliveira, Camila Ferreira Azevedo, Ana Carolina Campana Nascimento, Diego Jarquin, Moyses Nascimento   +5 more
doaj   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source