Results 111 to 120 of about 9,640,965 (252)

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Genotype by environment interaction in mustard (Brassica juncea) under Terai Agro-Climatic zone using the AMMI model and GGE biplot

Electronic Journal of Plant Breeding
In the present experiment, 71 Indian mustard (Brassica juncea) genotypes were evaluated in six environments for two successive years (three environments in each year) to identify the influence of environment over the genotypes and to identify the stable,
Supratim Sadhu1,2*, Moumita Chakraborty1, Suvendu Kumar Roy1, Rupsanatan Mandal3, Lakshmi Hijam1, Manoj Kanti Debnath4, Anjan Roy5 and Sanghamitra Rout5
doaj   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Factors affecting the genotype × environment interaction in spring triticale grown in a Mediterranean environment

, 2001
The identification of the genotypic and environmental factors responsible for the genotype by environment interaction is essential in any breeding program.
Deidda, Mauro, Motzo, Rosella, Giunta, Francesco   +2 more
core  

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Genotype-environment interaction and sociology: Contributions and complexities

Genotype-environment interaction (GxE) refers to situations in which genetic effects connected to a phenotype are dependent upon variability in the environment, or when genes modify an organism's sensitivity to particular environmental features.
Avison, William R., Seabrook, Jamie A.
core  

Genotype-Year interaction ANOVA for fresh yield studied during three years.

Genotype-Year interaction ANOVA for fresh yield studied during three years.
Md. Ashraful Alam (7434188), Md. Atikur Rahman (13955704), Md. Riazul Islam (6270136), Ahmed Gaber (11917619), Srabanti Roy (14948968), Md. Mushfiqur Rahman (7382468), Md. Rafiqul Islam (403453), Akbar Hossain (12009419), Md. Marufur Rahman (14948962), Abu Jafor Obaidullah (17817288), Riyadh S. Almalki (17817294), Md. Nasirul Farid (17817291), Shailendra Nath Mozumder (14948971)   +12 more
core   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Statistical Genetic Approaches to Investigate Genotype-by-Environment Interaction: Review and Novel Extension of Models [PDF]

Statistical genetic models of genotype-by-environment (G×E) interaction can be divided into two general classes, one on G×E interaction in response to dichotomous environments (e.g., sex, disease-affection status, or presence/absence of an exposure) and ...
Sarah Williams-Blangero, Diego, Vincent P., David Ortiz, Marcio Almeida, Eron G. Manusov, Vincent P. Diego, Sandra Laston, Laston, Sandra, Ortiz, David, Manusov, Eron G., John Blangero, Blangero, John, Williams-Blangero, Sarah, Almeida, Marcio   +13 more
core   +1 more source