Results 91 to 100 of about 26,046,977 (327)

Alpha-1 antitrypsin genotypes in breast cancer patients [PDF]

Breast Cancer Research, 2005
Alpha-1 antitrypsin (1-AT) is a secretory glycoprotein mainly produced in the liver and monocytes. It is the most abundant serine protease inhibitor in human plasma. Proteolytic enzymes play a significant role in the expression of the malignant phenotype, including the loss of growth regulation, invasiveness and formation of metastases. Deficiency of 1-
El-Akawi, Z, Nusier, M, Sawalha, DH
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans [PDF]

Genomics & Informatics, 2015
Fulminant type 1 diabetes (T1DM) is a distinct subtype of T1DM that is characterized by rapid onset hyperglycemia, ketoacidosis, absolute insulin deficiency, and near normal levels of glycated hemoglobin at initial presentation.
Soo Heon Kwak, Yoon Ji Kim, Jeesoo Chae, Cue Hyunkyu Lee, Buhm Han, Jong-Il Kim, Hye Seung Jung, Young Min Cho, Kyong Soo Park   +8 more
doaj   +1 more source

inPHAP: Interactive visualization of genotype and phased haplotype data [PDF]

, 2014
Background: To understand individual genomes it is necessary to look at the variations that lead to changes in phenotype and possibly to disease. However, genotype information alone is often not sufficient and additional knowledge regarding the phase of ...
Jäger, Günter, Nieselt, Kay, Peltzer, Alexander   +2 more
core   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

New Dengue Virus Type 1 Genotype in Colombo, Sri Lanka

Emerging Infectious Diseases, 2011
The number of cases and severity of disease associated with dengue infection in Sri Lanka has been increasing since 1989, when the first epidemic of dengue hemorrhagic fever was recorded. We identified a new dengue virus 1 strain circulating in Sri Lanka
Hasitha A. Tissera, Eng Eong Ooi, Duane J. Gubler, Ying Tan, Barathy Logendra, Wahala M.P.B. Wahala, Aravinda M. de Silva, M.R. Nihal Abeysinghe, Paba Palihawadana, Sunethra Gunasena, Clarence C. Tam, Ananda Amarasinghe, G. William Letson, Harold S. Margolis, Aruna Dharshan De Silva   +14 more
doaj   +1 more source

Sheepdrove Organic Farm Breed and Feed 1a Interim Report [PDF]

, 2004
• This interim report summarises the results of the first part of the breed and feed 1 trial, a final report will follow the completion of the second half of the trial.
O'Brien, Josie
core  

Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis. [PDF]

, 2009
Background: Recent evidence suggests that distinction of subsets of rheumatoid arthritis (RA) depending on anticyclic citrullinated peptide antibody (anti-CCP) status may be helpful in distinguishing distinct aetiopathologies and in predicting the ...
Burmester, G.R., Dörner, T., Egerer, K., Gruber, R., Hoppe, B., Häupl, T., Kiesewetter, H., Salama, A.   +7 more
core   +1 more source

GS‐9857 in patients with chronic hepatitis C virus genotype 1–4 infection: a randomized, double‐blind, dose‐ranging phase 1 study

Journal of Viral Hepatitis, 2016
GS‐9857, an inhibitor of the hepatitis C virus (HCV) nonstructural protein (NS) 3/4A, demonstrates potent activity against HCV genotypes 1–6 and improved coverage against commonly encountered NS3 resistance‐associated variants (RAVs).
M. Rodríguez-Torres, S. Glass, Jae H. Hill, B. Freilich, D. Hassman, A. Bisceglie, Joseph Taylor, Brian J. Kirby, H. Dvory‐Sobol, Jenny C. Yang, Di An, L. Stamm, D. Brainard, Su Young Kim, D. Krefetz, William B. Smith, T. Marbury, E. Lawitz   +17 more
semanticscholar   +1 more source

WHOLE GENOME COMPOSITION DISTANCE FOR HIV-1 GENOTYPING [PDF]

Series on Advances in Bioinformatics and Computational Biololgy, 2006
Existing HIV-1 genotyping systems require a computationally expensive phase of multiple sequence alignments and the alignments must have a sufficiently high quality for accurate genotyping. This is particularly a challenge when the number of strains is large.
Xiaomeng, Wu, Randy, Goebel, Xiu-Feng, Wan, Guohui, Lin   +3 more
openaire   +2 more sources