Results 111 to 120 of about 1,259,951 (349)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Prevalence and potential impact of human pegivirus-1 on HIV-1 disease progression among Indian PLHIV

Journal of Infection in Developing Countries
Introduction: Human pegivirus-1 (HPgV-1) influences the pathogenesis and outcome of viral infections. We investigated the prevalence and impact of HPgV-1 due to the paucity of studies on Indian people living with HIV (PLHIV). Methodology: Samples were
Diviya Alex, Runal J Steve, Veena V Ramalingam, John P Demosthenes, Gopinathan Vijayalakshmi, Ben C Ghale, Priscilla Rupali, George M Varghese, Dolly Daniel, Grace Rebekah, Gnanadurai J Fletcher, Priya Abraham, Rajesh Kannangai   +12 more
doaj   +1 more source

The Number of Different Binary Functions Generated by NK-Kauffman Networks and the Emergence of Genetic Robustness [PDF]

, 2000
We determine the average number $ \vartheta (N, K) $, of \textit{NK}-Kauffman networks that give rise to the same binary function. We show that, for $ N \gg 1 $, there exists a connectivity critical value $ K_c $ such that $ \vartheta(N,K) \approx e ...
David Romero, Federico Zertuche, Unidad Cuernavaca   +2 more
core   +3 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Peginterferon alpha-2b plus ribavirin for chronic hepatitis C virus mixed genotype infection

Annals of Hepatology, 2014
Background and aim. The treatment efficacy of peginterferon plus ribavirin for patients with HCV genotype 1 is inferior to that in patients with HCV genotype 2, but the efficacy among patients with mixed HCV genotype 1 + 2 is less clear.
Ching-Chung Lin, Chia-Hsien Wu, Huan-Lin Chen, I-Tsung Lin, Shen-Yung Wang, Tsang-En Wang, Horng-Yuan Wang, Shou-Chuan Shih, Ming-Jong Bair, M.D.   +8 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Efficacy and safety of new protease inhibitor faldaprevir in treatment of hepatitis C

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2013
The aim of review. To discuss potentials of application of new NS3/NS4 protease inhibitor faldaprevir at chronic hepatitis C with genotype 1 HCV, including patients without response to previous antiviral therapy, liver cirrhosis, and to estimate its ...
M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin   +2 more
doaj  

Distribution of HCV genotypes and HCV RNA viral load in different regions of Mexico

Annals of Hepatology, 2010
Background and aim. To identify the geographic distribution of hepatitis C virus (HCV) genotypes and HCV RNA viral load in a large number of HCV-infected carriers in Mexico.Methods.
Ricardo Jimenez-Mendez, Felipe Uribe-Salas, Paulo López-Guillen, Laura Cisneros-Garza, Gilberto Castañeda-Hernandez, Dr.   +4 more
doaj   +1 more source

O113 HIV-1 clade C resistance genotypes after first virological failure in a large community ART programme [PDF]

, 2008
Catherine Orrell, Rochelle P. Walensky, E Losina, KA Freedberg, Rachel C. Wood   +4 more
openalex   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source