Results 191 to 200 of about 26,046,977 (327)

Indigenous Hepatitis E Virus Genotype 1 Infection, Uruguay

Emerging Infectious Diseases, 2014
Santiago Mirazo, Victoria Mainardi, Natalia Ramos, Solange Gerona, Andrea Rocca, Juan Arbiza   +5 more
doaj   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Impact of ribavirin dose reduction during treatment in chronic hepatitis C genotype 1 patients [PDF]

Clinical and Molecular Hepatology, 2012
Woo Jin Chung
doaj   +1 more source

Chronic Hepatitis E With Genotype 1-Masquerading as Allograft Rejection After LiverTransplantation. [PDF]

J Clin Exp Hepatol, 2021
Rathi S, Duseja A, Thakur V, Ratho RK, Singh MP, Taneja S, Das A, Aggarwal R, Dhiman RK, Chawla YK.   +9 more
europepmc   +1 more source

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Advanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li, Zexuan Zhang, Zihan Xie, Cheng Jin, Zhipeng Wang, Changwei Yuan, Jun Zhu, Jielin Tang, Mengzhen Li, Dingfeng Zou, Xinyu Mang, Jun Liu, Dingyao Chen, Qi Geng, Yan Lu, Ning Zhang, Shiying Miao, Jing Peng, Kai Li, Wei Song   +19 more
wiley   +1 more source

Genotype-phenotype correlation in multiple endocrine neoplasia type 1

JCI Insight
BACKGROUND Among patients with multiple endocrine neoplasia type 1 (MEN1), 80% develop duodenopancreatic neuroendocrine tumors (dpNETs), of whom 15%–25% die of metastasis. There is a need to identify biomarkers to predict aggressive disease.
Charlita C. Worthy, Rana Tora, Chandra N. Uttarkar, James M. Welch, Lynn Bliss, Craig Cochran, Anisha Ninan, Sheila Kumar, Stephen Wank, Sungyoung Auh, Lee S. Weinstein, William F. Simonds, Sunita K. Agarwal, Jenny E. Blau, Smita Jha   +14 more
doaj   +1 more source

Diagnostic Performance and Kinetics of Hepatitis E Viral RNA and IgM Antibody Test Positivity in a Genotype 1 Outbreak in South Sudan. [PDF]

J Infect Dis
Koyuncu A, Nesbitt RC, Alvarez C, Asilaza KV, Wamala J, Haile M, Gignoux E, Albela M, Gurley ES, Loro FB, Biem D, Rull M, Rumunu J, Ciglenecki I, Eckerle I, Azman AS.   +15 more
europepmc   +1 more source

Feline morbillivirus in northwestern Italy: first detection of genotype 1-B. [PDF]

J Feline Med Surg, 2021
Muratore E, Cerutti F, Colombino E, Biasibetti E, Caruso C, Brovida C, Cavana P, Poncino L, Caputo MP, Peletto S, Masoero L, Capucchio MT.   +11 more
europepmc   +1 more source

Effectiveness of 8‐ or 12‐weeks of ledipasvir and sofosbuvir in real‐world treatment‐naïve, genotype 1 hepatitis C infected patients

Alimentary Pharmacology and Therapeutics, 2017
Michael P. Curry, E. B. Tapper, Bruce R. Bacon, Douglas T. Dieterich, S. Flamm, L. Guest, Kris V Kowdley, Y. Lee, S. Milligan, N. Tsai, Z. Younossi, N. Afdhal   +11 more
semanticscholar   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source