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GENOTYPE x ENVIRONMENT INTERACTIONS (1)

, 1972
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Natural history of chronic hepatitis C: Genotype 1 versus genotype 6

Journal of Hepatology, 2010
Data on the natural history of chronic hepatitis C virus (HCV) genotype 6 is lacking.We compared the natural history of 138 HCV genotype 1 patients (median age: 50) with 78 HCV genotype 6 patients (median age: 46.5). Baseline demographic data including gender, route of transmission, liver biochemistry, HCV RNA levels, and serial alanine ...
, James Fung, Ching-Lung Lai
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Hepatitis C genotype 1

Current Opinion in Infectious Diseases, 2014
To assess advances in the treatment of genotype 1 (G1 hepatitis C virus), in particular, the development of new interferon (and ribavirin)-free treatment regimes.The treatment of hepatitis C has advanced rapidly over the last 24 months. Newer interferon-containing regimes have been developed with improved tolerability, and interferon-free regimes with ...
Graham R, Foster, Sampath, De Silva
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Genotypic subtypes of HIV-1 in Cameroon

AIDS, 1994
The only two HIV-1 strains (ANT70 and MVP5180) reported to date from Cameroon are members of the outlier clade (group O). In this study, we assessed the prevalence of group O viruses and other HIV-1 subtypes in Cameroon.A phylogenetic analysis of 18 HIV-1 strains isolated from seropositive individuals from Yaoundé and Douala, Cameroon.A 900 base-pair ...
Nkengasong, J. N., Janssens, W., Heyndrickx, L., Fransen, K., Ndumbe, P. M., Motte, J., Leonaers, A., Ngolle, M., Ayuk, J., Piot, P., van der Groen, G.   +10 more
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GBV-C/HGV genotypes: Proposed nomenclature for genotypes 1-5

Journal of Medical Virology, 2000
The GB virus-C and hepatitis G virus (GBV-C/HGV) are variants of the same flavivirus. This proposal attempts to clarify the conflicting nomenclature for GBV-C/HGV genotypes. The first three genotypes described were genotype 1 (West Africa); genotype 2 (US/Europe) and genotype 3 (Asia).
T J, Tucker, H E, Smuts
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Hepatitis C virus genotype 4: Genotype 1's little brother

Journal of Viral Hepatitis, 2016
SummaryTreatment for hepatitis C virus genotype 4 infection has undergone a major advance over the past 5 years with the emergence of direct‐acting antiviral agents. Previously, genotype 4 treatment had been limited to the combination of pegylated interferon and ribavirin, with low rates of sustained virological response. The combinations of new direct‐
J, Llaneras, M, Riveiro-Barciela, M, Buti, R, Esteban   +3 more
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Genotypic Characterization of HIV Type 1 in Jamaica

AIDS Research and Human Retroviruses, 2011
This study seeks to analyze nearly full-length viral genomes for distinct genetic characteristics that are unique to local or regional strains and to identify regions that have high variability or are highly conserved. Nearly full length sequences of seven HIV-1 samples were obtained to ascertain the circulating subtype diversity in the HIV-1 epidemic ...
Marcia E, Roye, Icolyn I, Amarakoon, Cindy-Leigh, Hamilton, Lindsay M, Eyzaguirre, Peter, Figueroa, Jean K, Carr   +5 more
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Treatment of Chronic HCV Genotype 1 Coinfection

Current HIV/AIDS Reports, 2015
Several all-oral direct-acting antiviral (DAA) combination therapies including two fixed-dose combinations (FDCs) have been recently licensed for treatment of hepatitis C virus (HCV) genotype 1 infection. Results of pivotal trials with these new compounds are now also available in human immunodeficiency virus (HIV)/HCV-coinfected patients, highlighting
Christoph, Boesecke, Jürgen K, Rockstroh   +1 more
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HIV-1 genotypic and phenotypic resistance

Clinics in Laboratory Medicine, 2002
Antiretroviral failure caused by the development of drug resistance in HIV-1 is an increasingly common clinical problem. Two types of resistance assays are available to clinicians. Genotypic assays determine the presence of mutations associated with drug resistance.
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Neuregulin-1 genotypes and eye movements in schizophrenia

European Archives of Psychiatry and Clinical Neuroscience, 2009
Neuregulin-1 (NRG-1) is a putative susceptibility gene for schizophrenia but the neurocognitive processes that may involve NRG-1 in schizophrenia are unknown. Deficits in antisaccade (AS) and smooth pursuit eye movements (SPEM) are promising endophenotypes, which may be associated with brain dysfunctions underlying the pathophysiology of schizophrenia.
Haraldsson, H.M., Ettinger, U., Magnusdottir, B.B., Ingason, A., Hutton, S.B., Sigmundsson, T., Sigurdsson, E., Petursson, H.   +7 more
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