Results 61 to 70 of about 26,046,977 (327)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Current Treatment Of Chronıc Hepatıtıs C Genotype 1

Van Tıp Dergisi, 2018
Hepatitis C virus (HCV) causes both acute and chronic hepatitis. Following acute HCV infection, chronic infection develops in about %80 of patients. In years, Chronic hepatitis C can progress to cirrhosis, hepatocellular carcinoma (HCC) or may result in ...
Mesut Aydın, Ahmet Cumhur Dülger
doaj   +1 more source

Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations. [PDF]

, 2020
"Quantile-dependent expressivity" is a dependence of genetic effects on whether the phenotype (e.g., triglycerides) is high or low relative to its distribution in the population.
Williams, Paul T
core   +1 more source

Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations [PDF]

, 2008
Background: Haptoglobin (Hp) α-chain alleles 1 and 2 account for 3 phenotypes that may influence the course of inflammatory diseases via biologically important differences in their antioxidant, scavenging, and immunomodulatory properties.
Altorjay, István, Barta, Zsolt, Dinya, T., Földi, I., Gyetvai, A., Hársfalvi, Jolán, Kapitany, A., Korponay-Szabó, Ilma Rita, Lakatos, Péter László, Mate, I., Nemes, E., Papp, Mária, Szathmari, E., Toth, L., Tumpek, J., Udvardy, M., Varvolgyi, C., Veres, Gábor   +17 more
core   +1 more source

Efficacy of Direct-Acting Antiviral Combination for Patients With Hepatitis C Virus Genotype 1 Infection and Severe Renal Impairment or End-Stage Renal Disease.

Gastroenterology, 2016
BACKGROUND & AIMS Although hepatitis C virus (HCV) infection is common in patients with end-stage renal disease, highly efficacious, well-tolerated, direct-acting antiviral regimens have not been extensively studied in this population.
P. Pockros, K. Reddy, P. Mantry, E. Cohen, M. Bennett, M. Sulkowski, D. Bernstein, D. Cohen, N. Shulman, Deli Wang, Amit Khatri, M. Abunimeh, T. Podsadecki, E. Lawitz   +13 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Morphometric and biochemical features of different Bunias orientalis L. genotypes in the M. M. Gryshko National Botanical Garden of the NAS of Ukraine

Plant Varieties Studying and Protection, 2021
Purpose. Determine a number of morphometric and biochemical parameters of various genotypes of Bunias orientalis L. in the M. M. Gryshko National Botanical Garden of the NAS of Ukraine (NBG). Methods. Plant samples of B. orientalis (6 genotypes created
O. M. Vergun, D. B. Rakhmetov, O. V. Shymanska, S. O. Rakhmetova, O. P. Bondarchuk, V. V. Fishchenko   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Number of Different Binary Functions Generated by NK-Kauffman Networks and the Emergence of Genetic Robustness [PDF]

, 2007
We determine the average number $ \vartheta (N, K) $, of \textit{NK}-Kauffman networks that give rise to the same binary function. We show that, for $ N \gg 1 $, there exists a connectivity critical value $ K_c $ such that $ \vartheta(N,K) \approx e ...
Bechte W., David Romero, de Visser J. A. G. M., Federico Zertuche, Harris B., Kauffman S. A., Kauffman S. A., Kauffman S. A., Kauffman S. A., Lewin B., Romero D., Shymko R. S., Wagner A., Weisbuch G., Winfree A. T.   +14 more
core   +4 more sources

Rate of photosynthetic induction in fluctuating light varies widely among genotypes of wheat. [PDF]

, 2019
Crop photosynthesis and yield are limited by slow photosynthetic induction in sunflecks. We quantified variation in induction kinetics across diverse genotypes of wheat for the first time.
Buckley, Thomas N, Merchant, Andrew M, Richards, Richard A, Salter, William T, Trethowan, Richard   +4 more
core