Results 51 to 60 of about 1,259,951 (349)
Phylogeography, Risk Factors and Genetic History of Hepatitis C Virus in Gabon, Central Africa [PDF]
, 2012 BACKGROUND: The epidemiological and molecular characteristics of hepatitis C virus (HCV) infection in the general population have been poorly investigated in Africa.
Besson, Guillaume +8 more
core +8 more sources
Phenotype–Genotype Correlation in Children with Neurofibromatosis Type 1 [PDF]
Neuropediatrics, 2018 AbstractNeurofibromatosis type 1 (NF1) is a common autosomal dominant disorder with an incidence of ∼1 in 4,000 live births. Neurofibromin, the gene product, is ubiquitously expressed at high levels in the nervous system and functions as a tumor suppressor.
BARREA, Christophe +4 more
openaire +2 more sources
Archives of Medical Science, 2019 Introduction Non-cirrhotic treatment-naive hepatitis C patients infected with genotype 1 can be treated with ledipasvir/sofosbuvir (LDV/SOF) for 8 weeks, but in practice this regimen is frequently extended up to 12 weeks at least in part due to ...
Dorota Zarębska-Michaluk +26 more
doaj +1 more source
Східноукраїнський медичний журнал, 2021 Endothelial dysfunction is considered one of the main mechanisms for the further development of arterial hypertension (AH) and its complications, and endothelin-1 (ЕТ-1) plays one of the key roles in this process.
Yu. O. Smiianova
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson +3 more
wiley +1 more source
Brazilian Journal of Infectious DiseasesThe combination of pegylated interferon (PEG-INF) and ribavirin is currently the best treatment for chronic hepatitis C, providing a sustained virological response (SVR) in 54%-63% of patients. In patients infected with hepatitis C virus (HCV) genotype 1,
Giovanni Faria Silva +7 more
doaj +1 more source
Adaptability of irrigated rice to temperature change in sahelian environments [PDF]
, 2011 To assess genotype adaptability to variable environments, we evaluated five irrigated rice genotypes, three new varieties, WAS161, a NERICA, IR32307 and ITA344, and two controls: Sahel 108, the most popular short-duration variety in the region, and IR64.
Bado, B.V. +4 more
core +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection [PDF]
New England Journal of Medicine, 2014 In phase 2 studies, treatment with the all-oral combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor ledipasvir resulted in high rates of sustained virologic response among previously untreated patients with hepatitis C virus (HCV) genotype 1 infection.We conducted a phase 3, open-label study involving previously ...
Afdhal, Nezam +106 more
openaire +6 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel +3 more
wiley +1 more source