Results 61 to 70 of about 1,259,951 (349)

Current Treatment Of Chronıc Hepatıtıs C Genotype 1

Van Tıp Dergisi, 2018
Hepatitis C virus (HCV) causes both acute and chronic hepatitis. Following acute HCV infection, chronic infection develops in about %80 of patients. In years, Chronic hepatitis C can progress to cirrhosis, hepatocellular carcinoma (HCC) or may result in ...
Mesut Aydın, Ahmet Cumhur Dülger
doaj   +1 more source

Morphometric and biochemical features of different Bunias orientalis L. genotypes in the M. M. Gryshko National Botanical Garden of the NAS of Ukraine

Plant Varieties Studying and Protection, 2021
Purpose. Determine a number of morphometric and biochemical parameters of various genotypes of Bunias orientalis L. in the M. M. Gryshko National Botanical Garden of the NAS of Ukraine (NBG). Methods. Plant samples of B. orientalis (6 genotypes created
O. M. Vergun, D. B. Rakhmetov, O. V. Shymanska, S. O. Rakhmetova, O. P. Bondarchuk, V. V. Fishchenko   +5 more
doaj   +1 more source

Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C [PDF]

, 2013
Comunicación cortaWe assessed the relationship between atazanavir (ATV)-based antiretroviral treatment (ART) and plasma hepatitis C virus (HCV) viral load in a population of HIV/HCV-coinfected patients.
Girón-González, José-Antonio, López Cortés, Luis Fernando, Mira, Jose A., Márquez, Manuel, Rivero-Juarez, Antonio, Santos-Gil, Ignacio De Los   +5 more
core  

Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations [PDF]

, 2008
Background: Haptoglobin (Hp) α-chain alleles 1 and 2 account for 3 phenotypes that may influence the course of inflammatory diseases via biologically important differences in their antioxidant, scavenging, and immunomodulatory properties.
Altorjay, István, Barta, Zsolt, Dinya, T., Földi, I., Gyetvai, A., Hársfalvi, Jolán, Kapitany, A., Korponay-Szabó, Ilma Rita, Lakatos, Péter László, Mate, I., Nemes, E., Papp, Mária, Szathmari, E., Toth, L., Tumpek, J., Udvardy, M., Varvolgyi, C., Veres, Gábor   +17 more
core   +1 more source

Boceprevir for Untreated Chronic HCV Genotype 1 Infection [PDF]

New England Journal of Medicine, 2011
Peginterferon-ribavirin therapy is the current standard of care for chronic infection with hepatitis C virus (HCV). The rate of sustained virologic response has been below 50% in cases of HCV genotype 1 infection. Boceprevir, a potent oral HCV-protease inhibitor, has been evaluated as an additional treatment in phase 1 and phase 2 studies.We conducted ...
Poordad, Fred, McCone, Jonathan, Bacon, Bruce R., Bruno, Savino, Manns, Michael P., Sulkowski, Mark S., Jacobson, Ira M., Reddy, K. Rajender, Goodman, Zachary D., Boparai, Navdeep, DiNubile, Mark J., Sniukiene, Vilma, Brass, Clifford A., Albrecht, Janice K., Bronowicki, Jean-Pierre, Colombato, L., Curciarello, J., Silva, M., Tanno, H., Terg, R., Adler, M., Langlet, P., Lasser, L., Nevens, F., Anderson, F., Bailey, R., Bilodeau, M., Cooper, C., Feinman, S. V., Heathcote, J., Levstik, M., Ramji, A., Sherman, M., Shafran, S., Yoshida, E., Achim, A., Ben Ali, S., Bigard, M. -A., Bonny, C., Bourliere, M., Boyer-Darrigrand, N., Canva, V., Couzigou, P., De Ledinghen, V., Guyader, D., Hezode, C., Larrey, D., Latournerie, M., Marcellin, P., Mathurin, P., Maynard-Muet, M., Moussalli, J., Poupon, R., Poynard, T., Serfaty, L., Tran, A., Trepo, C., Truchi, R., Zarski, J. -P., Berg, T., Dikopoulos, N., Eisenbach, C., Galle, P. R., Gerken, G., Goeser, T., Gregor, M., Klass, D., Kraus, M. R., Niederau, C., Schlaak, J. F., Schmid, R., Thies, P., Schmidt, K., Thimme, R., Weidenbach, H., Zeuzem, S., Angelico, M., Carosi, G., Craxì, A., Mangia, A., Pirisi, M., Rizzetto, M., Taliani, G., Zignego, A. L., Reesink, H. W., Serejo, F., Reymunde, A., Rosado, B., Torres, E., Barcena Marugan, R., De La Mata, M., Calleja, J. L., CASTELLANO, Giancarlo, Diago, M., Esteban, R., Fernandez-Rodriguez, C., Sanchez Tapias, J., Serra Desfilis, M. A., Afdhal, N., Al-Osaimi, A., Balart, L., Bennett, M., Bernstein, D., Black, M., Bowlus, C., Boyer, T., Dalke, D., Davis, C., Davis, G., Davis, M., Everson, G., Felizarta, F., Flamm, S., Freilich, B., Galati, J., Galler, G., Ghalib, R., Gibas, A., Godofsky, E., Gordon, F., Gordon, S., Gross, J., Harrison, S., Herrera, J., Herrine, S., Hu, K. -Q., Imperial, J., Jones, D., Kilby, A., King, J., Koch, A., Kowdley, K., Krawitt, E., Kwo, P., Lambiase, L., Lawitz, E., Lee, W., Levin, J., Levine, R., Li, X., Lok, A., Luketic, V., Mailliard, M., McHutchison, J., Mikolich, D., Morgan, T., Muir, A., Nelson, Don, Nunes, F., Nyberg, A., Nyberg, L., Pandya, P., Pauly, M. P., Peine, C., Poleynard, G., Pound, D., Poulos, J., Rabinovitz, M., Ravendhran, N., Ready, J., Reindollar, R., Reuben, A., Riley, T., ROSSARO, Lucia, Rubin, R., Ryan, M., Santoro, J., Schiff, E., Sepe, T., Sherman, K., Shiffman, M., Sjogren, M., Sjogren, R., Smith, C., Stein, L., Strauss, R., Szyjkowski, R., Vargas, H., Vierling, J., Witt, D., Yapp, R., Younes, Z.   +181 more
openaire   +4 more sources

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

Influence of Crohn’s disease related polymorphisms in innate immune function on ileal microbiome [PDF]

, 2019
We have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome (“dysbiosis”) in a patient cohort.
Ciorba, Matthew A, Davidson, Nicholas O, Frank, Daniel N, Gathungu, Grace, Li, Ellen, Nelson, Leah M, Robertson, Charles E, Sartor, R. Balfour, Shiekh, Shehzad S, Tian, Xinyu, Wang, Xuefeng, Wolber, Ashley, Zhang, Yuanhao, Zhu, Wei   +13 more
core   +3 more sources

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

The effects of an intronic polymorphism in TOMM40 and APOE genotypes in sporadic inclusion body myositis. [PDF]

, 2015
A previous study showed that, in carriers of the apolipoprotein E (APOE) genotype ε3/ε3 or ε3/ε4, the presence of a very long (VL) polyT repeat allele in "translocase of outer mitochondrial membrane 40" (TOMM40) was less frequent in patients with ...
Barohn, R.J., Bettencourt, C., Brady, S., De Bleecker, J., De Paepe, B., Dimachkie, M.M., Fox, Z., Gang, Q., Hanna, M.G., Healy, E., Hilton-Jones, D., Holton, J.L., Houlden, H., Machado, P.M., Mantegazza, R., Mastaglia, F., Moggio, M., Mora, M., Needham, M., Parton, M., Ripolone, M., Shaibani, A., Shieh, P.B., Violano, R., Zanoteli, E., Zanotti, S.   +25 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source