Including copy number variation in association studies to predict genotypic values [PDF]
, 2010 The objective of this study was to investigate, both empirically and deterministically, the ability to explain genetic variation resulting from a copy number polymorphism (CNP) by including the CNP, either by its genotype or by a continuous derivation ...
Calus, M.P.L. +2 more
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Tailored second line therapy in asthmatic children with the arginine-16 genotype [PDF]
, 2012 The arginine-16 beta-2 receptor genotype confers increased susceptibility to exacerbations in asthmatic children taking regular long acting beta-2 agonists.
Aziz +27 more
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Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad. [PDF]
, 2005 The within-outbreak diversity of hepatitis E virus (HEV) was studied during the outbreak of hepatitis E that occurred in Sudan in 2004. Specimens were collected from internally displaced persons living in a Sudanese refugee camp and two camps implanted ...
Andraghetti, R +7 more
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Performance of assays for testing antibodies against porcine reproductive and respiratory syndrome virus in sera collected from swine farms in a region with an extreme virus heterogeneity [PDF]
, 2014 Porcine reproductive and respiratory syndrome is the most economically important viral disease in the swine industry worldwide. Porcine reproductive and respiratory syndrome virus (PRRSV) strains are classified into two distinct genotypes, the European ...
Karniychuk, U Uladzimir, Nauwynck, Hans
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Alpha‐1‐antitrypsin genotyping with mouthwash specimens [PDF]
European Respiratory Journal, 2001 α1‐antitrypsin (α1‐AT) deficiency is diagnosed as a two-stage procedure (concentration and phenotype). However the latter does not provide clues to the presence of null genes without family studies and obtaining blood from patients at a distance often proves difficult.
R A, Stockley, E J, Campbell
openaire +2 more sources
Colitis Following Initiation of Sofosbuvir and Simeprevir for Genotype 1 Hepatitis C. [PDF]
, 2015 Sofosbuvir and simeprevir are used for the treatment of chronic hepatitis C (HCV) genotype 1. Both drugs have been well-tolerated, with diarrhea noted in 6% cases with sofosbuvir, 16% with sofosbuvir plus simeprevir, and 0% with simeprevir.
Jakab, Simona +4 more
core +1 more source
Antiviral therapy in chronic hepatitis C (G1) in Russia: cost and effectiveness
Журнал инфектологии, 2015 Genotype 1 HCV treatment in Russia assume as bitherapy (pegylated interferon – PG plus ribavirin – RBV) as three therapy based on HCV protease inhibitor such as telaprevir (TLV), boceprevir (BCV) or simeprevir (SMV) plus PG/RBV.
A. V. Rudakova +3 more
doaj +1 more source
Early Experience of Sofosbuvir based Combination Therapy in “Real-Life” Cohort with Chronic Hepatitis-C Infection [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: There is scarcity of data in literature regarding the treatment response with Sofosbuvir (SOF) based therapy in Indian patients with chronic Hepatitis-C Virus (HCV) infection.
Rajiv Mehta +4 more
doaj +1 more source
Baseline anti-NS4a antibodies in combination with on-treatment quantitative HCV-RNA reliably identifies nonresponders to pegylated interferon-ribavirin combination therapy after 4 weeks of treatment [PDF]
, 2010 Background Early detection of nonresponders to hepatitis C therapy limits unnecessary exposure to treatment and its side-effects. A recent algorithm combining baseline anti-NS4a antibodies and on-treatment quantitative PCR identified nonresponders to a ...
de Knegt, Robert J +8 more
core +1 more source
Accuracy of the TRUGENEHIV-1Genotyping Kit [PDF]
Journal of Clinical Microbiology, 2003 ABSTRACTDrug resistance and poor virological responses are associated with well-characterized mutations in the viral reading frames that encode the proteins that are targeted by currently available antiretroviral drugs. An integrated system was developed that includes target gene amplification, DNA sequencing chemistry (TRUGENEHIV-1Genotyping Kit), and
Grant, Robert M. +12 more
openaire +3 more sources