Results 31 to 40 of about 735,853 (255)

Comparison of Structural Architecture of HCV NS3 Genotype 1 versus Pakistani Genotype 3a [PDF]

BioMed Research International, 2014
This study described the structural characterization of Pakistani HCV NS3 GT3a in parallel with genotypes 1a and 1b NS3. We investigated the role of amino acids and their interaction patterns in different HCV genotypes by crystallographic modeling.
Kaneez Fatima, Esam Azhar, Shilu Mathew, Ghazi Damanhouri, Ishtiaq Qadri   +4 more
openaire   +2 more sources

Treatment approach in chronic hepatitis C infection

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2016
Purpose: We aimed to evaluate retrospectively the results of treatment of patients with chronic hepatitis C in our clinic. Material and Methods: We evaluated the treatment results of 109 patients who treated with the diagnosis of chronic hepatitis C ...
Suheyla Komur, Ferit Kuscu, Aslihan Ulu, Ayse Seza inal, Behice Kurtaran, Yesim Tasova, Hasan S. Z. Aksu   +6 more
doaj   +1 more source

Efficacy of 8- versus 12-week treatment with ledipasvir/sofosbuvir in chronic hepatitis C patients eligible for 8 week regimen in a real-world setting

Archives of Medical Science, 2019
Introduction Non-cirrhotic treatment-naive hepatitis C patients infected with genotype 1 can be treated with ledipasvir/sofosbuvir (LDV/SOF) for 8 weeks, but in practice this regimen is frequently extended up to 12 weeks at least in part due to ...
Dorota Zarębska-Michaluk, Anna Piekarska, Jerzy Jaroszewicz, Jakub Klapaczyński, Marek Sitko, Magdalena Tudrujek-Zdunek, Krzysztof Tomasiewicz, Teresa Belica-Wdowik, Paweł Pabjan, Beata Lorenc, Agnieszka Czauż-Andrzejuk, Olga Tronina, Rafał Krygier, Witold Dobracki, Iwona Buczyńska, Krzysztof A. Simon, Dorota Dybowska, Waldemar Halota, Małgorzata Pawłowska, Jolanta Citko, Łukasz Laurans, Włodzimierz Mazur, Ewa Janczewska, Łukasz Socha, Zbigniew Deroń, Hanna Berak, Robert Flisiak   +26 more
doaj   +1 more source

Phenotype–Genotype Correlation in Children with Neurofibromatosis Type 1 [PDF]

Neuropediatrics, 2018
AbstractNeurofibromatosis type 1 (NF1) is a common autosomal dominant disorder with an incidence of ∼1 in 4,000 live births. Neurofibromin, the gene product, is ubiquitously expressed at high levels in the nervous system and functions as a tumor suppressor.
BARREA, Christophe, VAESSEN, Sandrine, BULK, Saskia, HARVENGT, Julie, Misson, Jean-Paul   +4 more
openaire   +2 more sources

PLASMA CONCENTRATION OF ENDOTHELIN-1 IN PATIENTS WITH HYPERTENSION ASSOCIATED WITH OBESITY, DEPENDING ON THE LYS198ASN POLYMORPHISM OF THE ENDOTHELIN-1 GENE

Східноукраїнський медичний журнал, 2021
Endothelial dysfunction is considered one of the main mechanisms for the further development of arterial hypertension (AH) and its complications, and endothelin-1 (ЕТ-1) plays one of the key roles in this process.
Yu. O. Smiianova
doaj   +1 more source

Boceprevir for Untreated Chronic HCV Genotype 1 Infection [PDF]

New England Journal of Medicine, 2011
Peginterferon-ribavirin therapy is the current standard of care for chronic infection with hepatitis C virus (HCV). The rate of sustained virologic response has been below 50% in cases of HCV genotype 1 infection. Boceprevir, a potent oral HCV-protease inhibitor, has been evaluated as an additional treatment in phase 1 and phase 2 studies.We conducted ...
Poordad, Fred, McCone, Jonathan, Bacon, Bruce R., Bruno, Savino, Manns, Michael P., Sulkowski, Mark S., Jacobson, Ira M., Reddy, K. Rajender, Goodman, Zachary D., Boparai, Navdeep, DiNubile, Mark J., Sniukiene, Vilma, Brass, Clifford A., Albrecht, Janice K., Bronowicki, Jean-Pierre, Colombato, L., Curciarello, J., Silva, M., Tanno, H., Terg, R., Adler, M., Langlet, P., Lasser, L., Nevens, F., Anderson, F., Bailey, R., Bilodeau, M., Cooper, C., Feinman, S. V., Heathcote, J., Levstik, M., Ramji, A., Sherman, M., Shafran, S., Yoshida, E., Achim, A., Ben Ali, S., Bigard, M. -A., Bonny, C., Bourliere, M., Boyer-Darrigrand, N., Canva, V., Couzigou, P., De Ledinghen, V., Guyader, D., Hezode, C., Larrey, D., Latournerie, M., Marcellin, P., Mathurin, P., Maynard-Muet, M., Moussalli, J., Poupon, R., Poynard, T., Serfaty, L., Tran, A., Trepo, C., Truchi, R., Zarski, J. -P., Berg, T., Dikopoulos, N., Eisenbach, C., Galle, P. R., Gerken, G., Goeser, T., Gregor, M., Klass, D., Kraus, M. R., Niederau, C., Schlaak, J. F., Schmid, R., Thies, P., Schmidt, K., Thimme, R., Weidenbach, H., Zeuzem, S., Angelico, M., Carosi, G., Craxì, A., Mangia, A., Pirisi, M., Rizzetto, M., Taliani, G., Zignego, A. L., Reesink, H. W., Serejo, F., Reymunde, A., Rosado, B., Torres, E., Barcena Marugan, R., De La Mata, M., Calleja, J. L., CASTELLANO, Giancarlo, Diago, M., Esteban, R., Fernandez-Rodriguez, C., Sanchez Tapias, J., Serra Desfilis, M. A., Afdhal, N., Al-Osaimi, A., Balart, L., Bennett, M., Bernstein, D., Black, M., Bowlus, C., Boyer, T., Dalke, D., Davis, C., Davis, G., Davis, M., Everson, G., Felizarta, F., Flamm, S., Freilich, B., Galati, J., Galler, G., Ghalib, R., Gibas, A., Godofsky, E., Gordon, F., Gordon, S., Gross, J., Harrison, S., Herrera, J., Herrine, S., Hu, K. -Q., Imperial, J., Jones, D., Kilby, A., King, J., Koch, A., Kowdley, K., Krawitt, E., Kwo, P., Lambiase, L., Lawitz, E., Lee, W., Levin, J., Levine, R., Li, X., Lok, A., Luketic, V., Mailliard, M., McHutchison, J., Mikolich, D., Morgan, T., Muir, A., Nelson, Don, Nunes, F., Nyberg, A., Nyberg, L., Pandya, P., Pauly, M. P., Peine, C., Poleynard, G., Pound, D., Poulos, J., Rabinovitz, M., Ravendhran, N., Ready, J., Reindollar, R., Reuben, A., Riley, T., ROSSARO, Lucia, Rubin, R., Ryan, M., Santoro, J., Schiff, E., Sepe, T., Sherman, K., Shiffman, M., Sjogren, M., Sjogren, R., Smith, C., Stein, L., Strauss, R., Szyjkowski, R., Vargas, H., Vierling, J., Witt, D., Yapp, R., Younes, Z.   +181 more
openaire   +4 more sources

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Using pegylated interferon alfa-2b and ribavirin to treat chronic hepatitis patients infected with hepatitis c virus genotype 1: are nonresponders and relapsers different populations?

Brazilian Journal of Infectious Diseases
The combination of pegylated interferon (PEG-INF) and ribavirin is currently the best treatment for chronic hepatitis C, providing a sustained virological response (SVR) in 54%-63% of patients. In patients infected with hepatitis C virus (HCV) genotype 1,
Giovanni Faria Silva, Rodrigo José Polônio, Maria Inês Moura Campos Pardini, Silvia Maria Corvino, Rita Maria Saccomano Henriques, Mari Nilce Peres, Liciana Vaz Arruda Silveira, Kunie Iabuki Rabello Coelho   +7 more
doaj   +1 more source

Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection [PDF]

New England Journal of Medicine, 2014
In phase 2 studies, treatment with the all-oral combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor ledipasvir resulted in high rates of sustained virologic response among previously untreated patients with hepatitis C virus (HCV) genotype 1 infection.We conducted a phase 3, open-label study involving previously ...
Afdhal, Nezam, Zeuzem, Stefan, Kwo, Paul, Chojkier, Mario, Gitlin, Norman, Puoti, Massimo, Romero-Gomez, Manuel, Zarski, Jean-Pierre, Agarwal, Kosh, Buggisch, Peter, Foster, Graham, Bräu, Norbert, Buti, Maria, Jacobson, Ira, Subramanian, G. Mani, Ding, Xiao, Mo, Hongmei, Yang, Jenny, Pang, Phillip, Symonds, William, Mchutchison, John, Muir, Andrew, Mangia, Alessandra, Marcellin, Patrick, Bourlière, Marc, Bronowicki, Jean-Pierre, Hezode, Christophe, Ratziu, Vlad, Serfaty, Lawrence, Berg, Thomas, Gallert, Peter, Gerken, Guido, Goeser, Tobias, Lohse, Ansgar, Mauss, Stefan, Thimme, Robert, Wedemeyer, Hans, Alberti, Alfredo, Andreone, Pietro, Angelico, Mario, Colombo, Massimo, Craxi, Antonio, Rizzetto, Mario, Rodriguez-Torres, Maribel, Andrade, Raúl, Crespo, F. Javier, Forns, Xavier, García-Samaniego, Javier, Brown, Ashley, Cramp, Matthew, Dusheiko, Geoffrey, Mutimer, David, Ustianowski, Andrew, Albers, Christopher, Arora, Sanjeev, Beavers, Kimberly, Bennett, Michael, Bernstein, David, Brown Jr., Robert, Chung, Raymond, Cooper, James, Davis, Mitchell, Di Bisceglie, Adrian, Dretler, Robin, Elion, Richard, Everson, Gregory, Flamm, Steven, Freilich, Bradley, Fried, Michael, Galati, Joseph, Ghalib, Reem, Gordon, Stuart, Han, Steven-Huy, Hawkins, Trevor, Herring, Robert, Hinestrosa, Federico, Jeffer, Lennox, Kowdley, Kris V, Kugelmas, Marcelo, Lawitz, Eric, Lee, William, Morgan, Timothy R, Nahass, Ronald, Nelson, David, Nguyen, Mindie, Patel, Keyur, Pockros, Paul, Poleynard, Gary, Poterucha, John, Poulos, John, Pound, David, Pruitt, Ronald, Ravendhran, Natarajan, Reddy, K. Rajender, Reindollar, Robert, Rossaro, Lorenzo, Ruane, Peter, Rustgi, Vinod, Ryan, Michael, Saag, Michael, Schiff, Eugene, Sheikh, Aasim, Shiffman, Mitchell, Smith, Coleman, Sulkowski, Mark, Workowski, Kimberly, Younes, Ziad   +106 more
openaire   +6 more sources

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source