Results 71 to 80 of about 131,008 (302)
CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu +8 morewiley +1 more sourceMulti-environments Evaluation of Zn and Fe Enhanced Bread Wheat Genotypes in Optimum Areas of Ethiopia
International Journal of Bio-Resource and Stress Management
A multi-location experiment was conducted during June, 2020–October, 2021 under rainfed condition at Kulumsa, Asasa, Adet, Holeta, and Sinana Research centers, Ethiopia to evaluate the genotype-by-environment interaction effect and grain yield stability Alemu Dabi, Gadisa Alemu, Berhanu Sime, Ruth Duga, Negash Geleta, Abebe Delessa, Tafesse Solomon, Habtemariam Zegaye, Cherinet Kasahun, Dawit Asnake, Bayisa Asefa, Abebe Getamesay, Demeke Zewudu, Ayele Badebo, Bekele Abeyo, Tilahun Bayisa, Endashaw Girma, Velu Govindan, Zerihun Tadesse +18 moredoaj +1 more sourceFinding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more sourceGenotype x environment interaction of rice genotype
IOP Conference Series: Earth and Environmental Science, 2020 Abstract Grain yield was influenced by genotype, environment and, genotype x environment interaction, so the maximum potential of rice will appear when planted in a suitable environment. The study aims to estimate grain yield stability of 20 genotypes of rice in dry season of 2014 in three locations.T Sitaresmi, U Susanto, E F Pramudyawardani, null Nafisah, Y Nugraha, P Sasmita +5 moreopenaire +1 more sourceEnvironmental stratification based on a 28 x 28 diallel of open-pollinated maize varieties
Crop Breeding and Applied Biotechnology, 2008 The objective of this study was to assess the representativeness of the test environments used by the maize breeding program of Embrapa in the first phase of genotype evaluation.Cleso Antônio Patto Pacheco, Heyder Diniz Silva, Manoel Xavier dos Santos, Paulo Evaristo de Oliveira Guimarães, Sidney Netto Parentoni, Elto Eugênio Gomes e Gama, Carlos Alberto Scapim, Walter Fernandes Meirelles, Hélio Wilson Lemos de Carvalho, Pedro Abel Vieira Junior +9 moredoaj Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function [PDF]
, 2012 Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC).Wenbo Tang (110161), Alisa K. Manning (110227), Heinrich, J (Joachim), Thomas Lumley (57337), Sood, A, R Graham Barr, Brusselle, Guy G., Loth, Daan W, Akshay Sood (71826), O'Connor, George T, Liu, YM, Stephen S. Rich (7634141), Harris, Tamara B, Fornage, Myriam, Alisa K. Manning (7634102), Stephanie J. London (62450), Josée Dupuis (28859), Probst-Hensch, Nicole, Glaser, S., Chen, TH, Elliott, Paul, Eiriksdottir, Gudny, Zhai, G., Jason Z. Liu (7634093), Patricia A. Cassano (110298), Hugues Aschard (110171), Joachim Heinrich (60421), Guy G Brusselle, Couper, D. J., Gu, Xiangjun, Uitterlinden, Andre G., Smith, AV, Couper, DJ, Lenore J. Launer (110269), Matthias Wjst (56613), Myriam Fornage (45591), Kritchevsky, S. B., Postma, Dirkje S., Liu, Y, Mirel, D. B., Rurth J.F. Loos (7634099), H. Marike Boezen (7634168), Uitterlinden, André G, Hysi, Pirro G., R. Graham Barr (7634171), Timothy D. Spector (7634159), Glaeser, S, Loos, Ruth J F, Christer Janson, Burkart, Kristin Marie, Barr, R.G., Heinrich, Joachim, Eiriksdottir, G, Hysi, P., Boezen, H Marike, Zhai, GJ, Liu, Jason, Probst-Hensch, Nicole M, Hancock, D.B., O Dale Williams, George T. O'Connor (110263), Jason Z. Liu (110210), Uitterlinden, AG, Hofman, A., Heckbert, Susan R, David P Strachan, Daan W. Loth (7634072), Louise V. Wain (7588511), Tamara B Harris, Smith, Albert V, Jarvis, Deborah, Imboden, M., Launer, Lenore J, Heckbert, Susan R., Hysi, PG, Morrison, A. C., Marciante, K. D., Rich, Stephen S., Hartikainen, Anna-Liisa, Mirel, Daniel B, Harris, Tamara, Liu, Jason Z, Jarvelin, Marjo-Riitta, Kritchevsky, S.B., Kari E. North (68131), Aldrich, Melinda C., Manning, A. K., Koch, B., Couper, David J., Timothy D Spector, Curjuric, I., Wilk, J. B., Eijgelsheim, Mark, North, Kari E, Louise V Wain, Rivadeneira, F, Williams, O. D., Homuth, G, Marciante, KD, Cassano, P. A., Joanna Smolonska (101730), Susan R. Heckbert (7634165), Strachan, David P., Jarvelin, M.R., Henry Völzke (64286), Boezen, H. M., Marciante, Kristin D., Vonk, J.M., Jerome I. Rotter (7634114), Ramasamy, A, Alisa K Manning, Loehr, L.R., Lumley, T., Amanda Henry, Daniel B. Mirel (7634153), Mark Eijgelsheim (110185), Bernd Meibohm (110267), Manichaikul, A, Manichaikul, Ani, Amy R Bentley, Daan W Loth, Kristin D. Marciante (110230), Aldrich, Melinda, Zhao, Jing Hua, Hysi, Pirro, Kurt Lohman, Alanna C Morrison, Melinda C. Aldrich (110234), Meibohm, B, O'Connor, George, Imboden, Medea, Gharib, Sina A, Wilk, Jemma B., Gudny Eiriksdottir (8872), Obeidat, Ma’en, Marchini, J, Stricker, Bruno H. C., Laurie, C.C., Kurt Lohman (110218), O. Dale Williams (110242), Stephen B. Kritchevsky (7240181), Alanna C. Morrison (110248), Lenore J Launer, Franceschini, N, Tamara B. Harris (7240184), Launer, L.J., O’Connor, George T., Probst-Hensch, NM, Maria Soler Artigas (7634069), Launer, Lenore J., Marchini, Jonathan, Dupuis, Josee, Hall, Ian, Tobin, M.D., Loehr, Laura, Nicole M. Probst-Hensch (7634162), London, S.J., Fernando Rivadeneira, Rich, S. S., Sina A. Gharib (63265), Cathy C. Laurie (110245), Kristin D. Marciante (7634105), Hancock, D. B., Stricker, BHC, Wareham, N.J., Tamara B. Harris (110195), Henry, A, Guangju Zhai (110167), Bonnie R. Joubert (110252), Ian P. Hall (7377620), Probst-Hensch, Nicole M., Rotter, Jerome I, Nicholas J Wareham, Vonk, Judith, Dana B. Hancock (110121), R. Graham Barr (109958), Franceschini, Nora, Hammond, Christopher J., Burkart, KM, Bruno H C Stricker, Rochat, Thierry, Rotter, Jerome, Tobin, Martin, Hall, I.P., Boezen, H. Marike, Loos, Ruth J. F., Artigas, M.S., Loth, Daan W., Josée Dupuis, Medea Imboden, Lohman, K, Hall, I. P., Deborah Jarvis, Wain, Louise V., Guy G. Brusselle (7634108), Burkart, K.M., André G. Uitterlinden (7634138), North, K.E., Loos, RJF, Judith M. Vonk (7634135), George T O'Connor, McArdle, Wendy L., Laurie, Cathy C., Barr, R. Graham, Dupuis, J, Khaw, K. T., Koch, B, Hancock, Dana, Burkart, Kristin, Manning, Alisa K., Tobin, Martin D, Jemma B Wilk, Völzke, H, Paul Elliott, Rochat, T., Artigas, Maria Soler, Probst-Hensch, N.M., Boezen, Hendrika, Homuth, G., Patricia A. Cassano (7634174), Stephanie J. London (7634180), Melinda C Aldrich, Gudnason, V, Albert V. Smith (7634078), Bentley, Amy, Pirro G. Hysi (110207), Smith, Albert, Gharib, SA, Rich, Stephen, Williams, O.D., Albert V Smith, Martin D Tobin, Marjo-Riitta Jarvelin (110290), Dana B. Hancock (7634066), Wareham, N. J., Guy G. Brusselle (110236), Wareham, NJ, Bruce M Psaty, Ani Manichaikul, Smith, Albert V., Anna-Liisa Hartikainen, Nicole M Probst-Hensch, Chen, T-H, Sood, A., Ruth J F Loos, Bentley, Amy R, Gu, X, Jarvelin, MR, Adaikalavan Ramasamy, Daniel B Mirel, Uitterlinden, A., Jing Hua Zhao, Bruno H. C. Stricker (110279), Burkart, Kristen M., Morrison, Alanna, Rotter, J.I., Hall, IP, Psaty, B. M., Meibohm, Bernd, Couper, David, Homuth, Georg, Harris, TB, Heckbert, S. R., Laurie, CC, Chen, T. H., Kritchevsky, Stephen, Mirel, Daniel B., Christopher J Hammond, Akshay Sood, Xiangjun Gu, Daan W. Loth (110140), Wareham, Nicholas J., Obeidat, M, Smolonska, J, Marciante, Kristin, Gharib, S.A., Laurie, C., Psaty, Bruce, Lumley, Thomas, Sven Gläser, André G. Uitterlinden (2213413), Hofman, Albert, Zhao, J.H., Zhao, JH, Jerome I. Rotter (103729), Loehr, Laura R, Yongmei Liu, Myriam Fornage, Cassano, Patricia A, Hartikainen, A. L., Xiangjun Gu (73651), Stricker, Bruno HC, Zhao, J. H., Gu, X.J., Volzke, H., Tang, W, Brusselle, GG, Bentley, A.R., Tang, Wenbo, Voelzke, Henry, Stephen B Kritchevsky, Boezen, Marike, Dana B Hancock, Laurie, Cathy C, London, S. J., Vilmundur Gudnason (8873), Brusselle, G.G., Strachan, DP, Jonathan Marchini (21497), Patricia A Cassano, Elliott, P., Susan R. Heckbert (110293), Wjst, M, Martin D. Tobin (110311), Wareham, Nicholas, North, KE, Spector, TD, David J Couper, Chen, Ting-hsu, Rotter, JI, Ramasamy, A., Nicholas J. Wareham (110277), Aldrich, M.C., Wain, Louise, Marjo-Riitta Jarvelin, Spector, Timothy D, Ma'en Obeidat, Manning, A.K., Psaty, Bruce M., Launer, Lenore, Lohman, Kurt, Adaikalavan Ramasamy (4841), Ma'en Obeidat (110232), Hartikainen, A.L., Peter Kraft, Gudnason, V., Dirkje S Postma, Strachan, D. P., Henry Völzke, Tobin, MD, Loehr, L. R., Morrison, Alanna C, Wain, LV, Thierry Rochat, Mcardle, Wendy, Smolonska, Joanna, Stricker, Bruno, Dirkje S. Postma (101740), Manning, AK, Barr, RG, Boezen, M., Kraft, Phillip, Vonk, JM, Loth, D.W., Henry, A., Soler, Artigas, Bentley, A. R., Obeidat, Ma'en, Hysi, P.G., Launer, L. J., Timothy D. Spector (110281), Strachan, David P, Brusselle, Guy, Christopher J. Hammond (110274), Liu, JZ, Loth, D. W., Vonk, Judith M., Wendy L. McArdle (110155), Bernd Meibohm, Loehr, LR, Hammond, Christopher J, Spector, T. D., Marchini, J., Cisca Wijmenga, Vonk, Judith M, Ting-hsu Chen, Ting-Hsu Chen (7634111), Barr, R Graham, Ruth J. F. Loos (110224), Hofman, Bert, Brusselle, G. G., North, Kari, Aschard, H., Zhai, G.J., Kraft, P., Stephen B. Kritchevsky (110259), Bonnie R Joubert, David J. Couper (110257), O'Connor, G. T., O'Connor, G.T., Heinrich, J., Ting-hsu Chen (110239), Judith M Vonk, Ramasamy, Adaikalavan, Psaty, Bruce M, Sven Gläser (110276), Nicholas J. Wareham (7584569), Wain, L. V., Boezen, M, Aldrich, MC, Hancock, DB, Heckbert, SR, Hammond, C. J., H Marike Boezen, Christopher J. Hammond (7252211), North, Kari E., Zhai, G, Jing Hua Zhao (73808), Lumley, T, Aldrich, M., Smolonska, J., Vonk, J. M., Mirel, D.B., Khaw, KT, Hartikainen, AL, Lenore J. Launer (7305602), Beate Koch (110151), Stricker, B. H. C., Smith, A.V., Heckbert, Susan, Kay-Tee Khaw, Williams, O. Dale, Uitterlinden, André, Hancock, Dana B., Ian P. Hall (110307), Kraft, P, Khaw, K-T, Kritchevsky, SB, Nora Franceschini, Jemma B. Wilk (110164), Wareham, Nicholas J, Georg Homuth (110202), Tobin, M. D., Curjuric, Ivan, Amy R. Bentley (110243), Joubert, B. R., Rochat, T, Gharib, Sina, Franceschini, N., Vilmundur Gudnason, Mirel, Daniel, Marciante, K.D., Guangju Zhai, Janson, Christer,, Artigas, MS, Laura R. Loehr (110214), Rivadeneira, Fernando, Rich, SS, Melinda C. Aldrich (6688181), Boezen, HM, Albert V. Smith (103644), Manning, Alisa K, Morrison, Alanna C., Janson, C, Wijmenga, C, Jarvelin, M-R, Bentley, AR, Obeidat, M., David J. Couper (7634132), Harris, T.B., Mark Eijgelsheim, Kristin M. Burkart (110174), Bentley, Amy R., Jing Hua Zhao (7634084), Kristin M. Burkart (7634087), Loth, DW, Jonathan Marchini, London, SJ, Judith M. Vonk (71591), Kristin D Marciante, Spector, Timothy, Rivandeneiro, Fernando, Ani Manichaikul (110134), Rotter, J. I., Liu, Y.M., Völzke, Henry, Aschard, Hugues, O'Connor, GT, Heinrich, J, Martin D. Tobin (7581161), Fornage, M., Barr, R. G., Bruce M. Psaty (103721), Gu, XJ, Zhai, Guangju, Jarvelin, M. R., Marciante, Kristin D, Ivan Curjuric (110179), Eiriksdottir, G., Susan R Heckbert, Sina A Gharib, Spector, Timothy D., Gläser, Sven, Homuyth, Georg, Medea Imboden (110145), Thomas Lumley, Hysi, Pirro G, Probst-Hensch, N. M., Gu, X., Harris, Tamara B., London, Stephanie J, Henry, Amanda, Liu, J.Z., Joubert, BR, Peter Kraft (15118), Bruce M. Psaty (7634144), Bruno H.C. Stricker (7634156), Jerome I Rotter, Heckbert, S.R., Strachan, David, Wjst, M., Cathy C. Laurie (7634123), Meibohm, B., Strachan, D.P., Launer, LJ (Lenore), Gudnason, Vilmundur, Hugues Aschard, Loehr, Laura R., Jarvis, D, Rich, S.S., Uitterlinden, André; id_orcid, Loth, Daan, Mirel, DB, Khaw, Kay-Tee, Postma, Dirkje S, Wain, L.V., Hall, Ian P, Rivadeneira, F., Deborah Jarvis (59834), Liu, Yongmei, Nicole M. Probst-Hensch (110284), Wilk, JB, Khaw, K.T., Ivan Curjuric, Karl E. North (7634150), Postma, D.S., Curjuric, I, Liu, Jason Z., Kristin M Burkart, David P. Strachan (7634177), McArdle, W.L., Burkart, Kristin M, Soler Artigas, María, Joanna Smolonska, Williams, O Dale, Kraft, Peter, Gläser, S, Pirro G. Hysi (7634090), Liu, J. Z., Eijgelsheim, M., Morrison, AC, Smith, A. V., Kay-Tee Khaw (110271), Wijmenga, Cisca, Albert Hofman, Elliott, P, Wendy L. McArdle (7634075), London, Stephanie J., Fornage, M, Hammond, C.J., Gharib, Sina A., André G Uitterlinden, Voelzke, H, Loos, R., María Soler Artigas (110124), Hammond, CJ, Postma, Dirkje, Joubert, Bonnie, O'Connor, George T., Laurie, Cathy, Stricker, B.H.C., Joubert, B.R., Chen, T.H., McArdle, Wendy L, Kritchevsky, Stephen B, Glaeser, Sven, Loos, RJ, Alanna C. Morrison (7634126), Aldrich, Melinda C, Brusselle, Guy G, Tang, W.B., Cassano, P.A., Uitterlinden, A.G., Cisca Wijmenga (32954), Joubert, Bonnie R., Imboden, M, Jemma B. Wilk (7634081), Jarvis, D., Rich, Stephen S, Ian P Hall, Christer Janson (83414), Sood, Akshay, Morrison, A.C., McArdle, WL, Harris, T. B., Hammond, Christopher, Amanda Henry (110129), Kari E North, Couper, David J, Psaty, BM, Wenbo Tang, London, Stephanie, McArdle, W., Cathy C Laurie, Hartikainen, A-L, Louise V. Wain (110260), Wjst, Matthias, Hancock, Dana B, Bonnie R. Joubert (7634129), Janson, C., Koch, Beate, David P. Strachan (110302), Loos, Ruth, Wijmenga, C., Cassano, PA, Pirro G Hysi, Joubert, Bonnie R, Stricker, Bruno H C, Stephanie J London, Eijgelsheim, M, Georg Homuth, H. Marike Boezen (101746), Dupuis, J., Manning, Alisa, Tang, W., Kritchevsky, Stephen B., Spector, T.D., Loos, R.J.F., George T. O'Connor (7634147), Manichaikul, A., Laura R Loehr, Amy R. Bentley (7634120), Psaty, B.M., Hofman, A, Postma, D., Stephen S. Rich (110262), Albert Hofman (107303), Wijmenga, Cisca; id_orcid, Matthias Wjst, Stricker, BH, Gharib, S. A., Wilk, Jemma, Burkart, Kristin M., Burkart, K. M., Beate Koch, Launer, LJ, O. Dale Williams (7634117), Cassano, Patricia A., Daniel B. Mirel (110265), Wilk, J.B., Joachim Heinrich, Tang, WB, Janson, Christer, Postma, DS, Stephen S Rich, North, K. E., Thierry Rochat (110261), Paul Elliott (27295), Laura R. Loehr (7634096), Hall, Ian P., Nora Franceschini (91434), Tobin, Martin D., Aschard, H, Wain, Louise V, Liu, Y., Couper, D.J., Rotter, Jerome I., Wendy L McArdle, Lohman, K., Gudny Eiriksdottir, Williams, OD, Jason Z Liu, Anna-Liisa Hartikainen (110272), Wilk, Jemma B, María Soler Artigas, Yongmei Liu (104713), Cassano, Patricia, Fernando Rivadeneira (61551), Loos, Ruth JF +678 morecore +1 more sourceCyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue. Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel +12 morewiley +1 more sourceMolecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith +12 morewiley +1 more source
