Results 51 to 60 of about 61,429,792 (207)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Genotype by environment interaction for grain yield in winter oat [PDF]

, 2020
The objective of this study was to examine the magnitude of genotype by environment interaction for grain yield and determine the adaptation of breeding lines of winter oat, grown in Southeast Bulgaria, using AMMI and GGE biplot methods.
Savova, Todorka, Dyulgerova, Boryana
core  

Genotype-by-Environment Interaction of Yam (Dioscorea species) for Yam Mosaic Virus Resistance, Dry Matter Content and Yield in Uganda

, 2022
Often, yam cultivars grown in different agro-ecologies show differential responses across production environments, a term known as genotype-by-environment interaction.
Emmanuel Boache Chamba, Titus Alicai, Richard Edema, Isaac Onziga Dramadri, Emmanuel Amponsah Adjei, Rolland Agaba, Williams Esuma, Alfred Adebo Ozimati, Thomas Lapaka Odong   +8 more
core   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Analysis of linear and nonlinear genotype × environment interaction [PDF]

, 2014
The usual analysis of genotype × environment interaction (G × E) is based on the linear regression of genotypic performance on environmental changes (e.g., classic stability analysis).
Yang, Rong-Cai
core   +1 more source

Extending Service Beyond Active Duty: Generalizability of Rheumatoid Arthritis Research Conducted Among US Veterans

Arthritis Care &Research, EarlyView.
Biomedical research involving US veterans continues to advance health care beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both veteran ...
Austin M. Wheeler, Joshua F. Baker, Jennifer L. Barton, Maria I. Danila, Tate M. Johnson, Kamini Kuchinad, Kaleb Michaud, Amir A. Razmjou, J. Steuart Richards, Namrata Singh, Isaac D. Smith, Katherine D. Wysham, Grant W. Cannon, Bryant R. England, Amy Joseph, Deana Lazaro, Katherine P. Liao, Courtney Loecker, Andreas Reimold, Beth I. Wallace, Ted R. Mikuls   +20 more
wiley   +1 more source

Genotype X Environment Interaction and Yield Stabliity of Breade Wheat (Triticum Eastivum L.) Genotype in Ethiopia using the Ammi Analisis [PDF]

, 2015
The G x E interaction makes it difficult to select the best performing as well as the most stable genotypes and so its efficient interpretation is important issue in plant improvement in Ethiopia.
Bacha, Temesgen, Tadesse, Zerihun, Alemerew, Sintayehu   +2 more
core   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Genotype by Environment Interaction and Yield Stability of Drought Tolerant Mung Bean [Vigna radiata (L.) Wilczek] Genotypes in Ethiopia [PDF]

, 2022
A multi-environment evaluation of mung bean genotypes was conducted in six environments across Ethiopia to select promising genotypes. This study was conducted to estimate the magnitude of genotypes by environment interaction (GEI) and seed yield ...
Mekbib, Firew, Ganta, Tekle Yoseph, Tadele, Zerihun, Amsalu, Berhanu   +3 more
core   +1 more source