Results 181 to 190 of about 10,430,018 (295)

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Evaluation of protective efficacy of an inactivated Japanese encephalitis virus genotype Ⅴ strain in mice. [PDF]

NPJ Vaccines
Lee JM, Kim SR, Ryou J, Choi JH, Shim SM.   +4 more
europepmc   +1 more source

DENV-1 Genotype V in Brazil: Spatiotemporal dispersion pattern reveals continuous co-circulation of distinct lineages until 2016. [PDF]

Sci Rep, 2018
de Bruycker-Nogueira F, Souza TMA, Chouin-Carneiro T, da Costa Faria NR, Santos JB, Torres MC, Ramalho ILC, de Aguiar SF, Nogueira RMR, de Filippis AMB, Dos Santos FB.   +10 more
europepmc   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Emergence of decapod hepanhamaparvovirus genotype V and its co-infection with <i>Enterocytozoon hepatopenaei</i> in cultured <i>Penaeus vannamei</i> in Thailand: Evidence from epidemiological, pathogenicity, and microbiome analyses. [PDF]

Vet World
Charoenwai O, Tanpichai P, Sukkarun P, Jeon HJ, Kim B, Han JE, Piamsomboon P.   +6 more
europepmc   +1 more source

Effects of the Japanese Encephalitis Virus Genotype V-Derived Sub-Viral Particles on the Immunogenicity of the Vaccine Characterized by a Novel Virus-Like Particle-Based Assay. [PDF]

Vaccines (Basel), 2019
Honjo S, Masuda M, Ishikawa T.
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Antitumor and immunostimulatory activities of a genotype V recombinant attenuated veterinary Newcastle disease virus vaccine. [PDF]

Oncol Lett, 2018
Ortega-Rivera OA, Quintanar JL, Del Toro-Arreola S, Alpuche-Solis ÁG, Esparza-Araiza MJ, Salinas E.   +5 more
europepmc   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

DENV-1 genotype V circulation during the nonepidemic period in the Northeast of São Paulo State endemic area. [PDF]

J Med Virol
de La-Roque DGL, Santos EV, Oliveira RAM, Slavov SN, Rodrigues ES, Fonseca V, Martins AJ, Giomo DB, Torres PMA, Gentil DCD, Catoia EA, Chiquito NDC, Medeiros APSS, Yamamoto AY, Passos LMR, Calado RT, Barros CRDS, Elias MC, Sampaio SC, Giovanetti M, Junior Alcantara LC, Covas DT, Kashima S.   +22 more
europepmc   +1 more source