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DENV-1 genotype V linked to the 2022 dengue epidemic in Southern Brazil

Journal of Clinical Virology, 2023
Even though Brazil is a country where the dengue virus (DENV) is endemic, until recently, Southern states did not have significant viral circulation, such as Rio Grande do Sul (RS), and some municipalities were even considered dengue-free. During 2022, these places have shown a sharp increase in the incidence of the disease, apparently following a ...
Juliana Schons Gularte   +12 more
openaire   +2 more sources

Type V Collagen Genotype and Exercise-Related Phenotype Relationships

Exercise and Sport Sciences Reviews, 2011
We have shown that a variant within COL5A1, which encodes a subunit of type V collagen, is associated with injury and performance phenotypes. Although seemingly unrelated, these phenotypes are associated directly or indirectly with the mechanical properties of musculoskeletal soft tissue.
Malcolm, Collins, Michael, Posthumus
openaire   +2 more sources

Simple and Reliable Factor V Genotyping by PNA-Mediated PCR Clamping

Thrombosis and Haemostasis, 1998
SummaryResistance to activated protein C (APC resistance) is the most common cause of thrombophilia and linked to a single point mutation in the factor V gene (G>A transition at nucleotide 1691). In the past, several PCR based methods have been proposed to determine the allelostatus of individual patients from small amounts of blood DNA including ...
M, Behn, M, Schuermann
openaire   +2 more sources

Asymptomatic carriership of factor V Leiden and genotypes of the fibrinogen gene cluster

British Journal of Haematology, 2003
Summary.We investigated the role of frequent fibrinogen polymorphisms in venous thromboembolic disease in conjunction with inherited thrombophilia. Two hundred unrelated subjects, all carriers of the factor V R506Q mutation (FV Leiden), were genotyped at the fibrinogen gene cluster.
MARCHETTI, Giovanna   +9 more
openaire   +2 more sources

Genotype III-Based Japanese Encephalitis Vaccines Exhibit Diminished Neutralizing Response to Reemerging Genotype V

The Journal of Infectious Diseases
Abstract Background Japanese encephalitis (JE) has been predominantly controlled through vaccination. However, the isolation of JE virus (JEV) genotype V (GV) in China in 2009, and the subsequent alarming increase in JE cases in the Republic of Korea since 2010, present a new challenge.
Ah-Ra Lee   +12 more
openaire   +2 more sources

Identification of Factor V Leiden Genotypes in Normal Pools

Blood
Protein C serves as a natural anticoagulant, becoming active when thrombin binds to thrombomodulin on endothelial cell surfaces. Activated Protein C (APC) normally breaks down factor Va and factor VIIIa, inhibiting them reduce thrombin production and thus regulating anticoagulant activity.
Bharath V Reddy   +3 more
openaire   +1 more source

Factor V Leiden and apolipoprotein E genotypes in severe femoropopliteal atherosclerosis with restenosis

Clinica Chimica Acta, 2007
The role of factor V (Leiden) mutation, thrombophilia, and apolipoprotein E (apoE) alleles in the pathogenesis of accelerated atherosclerosis and restenosis was studied in patients requiring reoperation within five years after femoropopliteal angioplasty with artificial grafts.One hundred ninety-eight consecutive patients with femoropopliteal ...
Vallus G   +9 more
openaire   +3 more sources

An Event-Driven Approach to Genotype Imputation on a Custom RISC-V Cluster

IEEE/ACM Transactions on Computational Biology and Bioinformatics
This article proposes an event-driven solution to genotype imputation, a technique used to statistically infer missing genetic markers in DNA. The work implements the widely accepted Li and Stephens model, primary contributor to the computational complexity of modern x86 solutions, in an attempt to determine whether further investigation of the ...
Jordan Morris   +6 more
openaire   +5 more sources

Genotype-Specific Transcriptomic Responses to Water Deficit in Ripening Berries of Vitis vinifera and V. vinifera × V. rotundifolia Genotypes

Drought tolerance breeding in grapevine requires understanding how genetic background reshapes stress-responsive transcriptional programs during berry ripening. Here, we profiled single-berry RNA-seq from ripening berries of Vitis vinifera cv. Syrah and a disease-resistant V. vinifera × V.
mengyao SHI   +4 more
openaire   +1 more source

Genotype pattern of factor V and XIII abnormalities in the Iranian population: A meta-analysis

Transfusion and Apheresis Science
Hemostatic disorders are significantly associated with morbidity and mortality. Hence, the examination of coagulation abnormalities is a cornerstone of prevention and therapy. This meta-analysis aimed to determine the genotype pattern of Factor V (FV) and XIII (FXIII) abnormalities in the Iranian population. Methods The search strategy was conducted in
Sadegh, Abbasian   +3 more
openaire   +2 more sources

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