Results 231 to 240 of about 14,985,405 (291)

GENOTYPE x ENVIRONMENT INTERACTIONS (1)

, 1972
openaire   +1 more source

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

Advanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao   +12 more
wiley   +1 more source

Optimizing resource allocation in <i>Miscanthus</i> breeding via sparse testing designs for genomic prediction. [PDF]

Front Plant Sci
Proma S, Lubanga N, Sacks E, Leakey ADB, Zhao H, Ghimire BK, Lipka AE, Njuguna JN, Yu CY, Seong ES, Yoo JH, Nagano H, Anzoua KG, Yamada T, Chebukin P, Jin X, Clark LV, Petersen KK, Peng J, Sabitov A, Dzyubenko E, Dzyubenko N, Glowacka K, Nascimento M, Campana Nascimento AC, Dwiyanti MS, Bagment L, Shaik A, Garcia-Abadillo J, Jarquin D.   +29 more
europepmc   +1 more source

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

Metabolomic phenotyping reveals the GxExS blind spot in berry fruit quality breeding. [PDF]

Front Plant Sci
Pacheco-Ruiz P, Postacchini S, Mezzetti B, Mazzoni L, Osorio S, Vallarino JG.   +5 more
europepmc   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Genome-wide analysis of genetic modifiers of Crohn's disease and ulcerative colitis risk in response to tobacco smoking. [PDF]

EBioMedicine
Bai J, Gacesa R, Björk JR, Jansen BH, Faber KN, Weersma RK, Dijkstra G, van der Sloot KWJ, Festen EAM, Initiative on Crohn and Colitis (ICC).   +9 more
europepmc   +1 more source