Results 281 to 290 of about 243,271 (342)

Leveraging polygenic risk scores to infer causal directions in genotype-by-environment interactions between complex traits. [PDF]

Hum Genet
Fentaw Z, Truong B, Jayasinghe D, Vedova CD, Hemani G, Benyamin B, Hyppönen E, Lee SH.   +7 more
europepmc   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Soybean Rust Resistance and Yield Performance of Elite Soybean Genotypes Across Diverse Environments in Uganda. [PDF]

Plant Environ Interact
Obua T, Sserumaga JP, Chigeza G, Malaala A, Namara M, Awio B, Okello S, Tukamuhabwa P.   +7 more
europepmc   +1 more source

GENOTYPE x ENVIRONMENT INTERACTIONS (1)

, 1972
openaire   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

Whole tissue imaging of cellular boundaries at sub‐micron resolutions for deep learning cell segmentation: Applications in the analysis of epithelial bending of ectoderm

Developmental Dynamics, EarlyView.
Abstract Background To understand cellular morphology, biologists have relied on traditional optical microscopy of tissues combined with tissue clearing protocols to image structures deep within tissues. Unfortunately, these protocols often struggle to retain cell boundary markers, especially at high enough resolutions necessary for precise cell ...
Sam C. P. Norris, Jimmy K. Hu, Neil H. Shubin   +2 more
wiley   +1 more source

Towards a sweetpotato genomic-enabled breeding: optimizing two-stage analysis of multi-environment augmented trials. [PDF]

Theor Appl Genet
Chaves S, Ssali R, Chagas JTB, Dias KOG, De Boeck B, Mendes T, Lindqvist-Kreuze H, Campos H, Yencho GC, da Silva Pereira G.   +9 more
europepmc   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Rethinking genomic selection under environmental uncertainty: toward learnable and dynamic environmental representations. [PDF]

Front Plant Sci
Yan J, Wang X.
europepmc   +1 more source