Results 41 to 50 of about 73,268 (241)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Selection of corn cultivars for yield, stability, and adaptability in the state of Amazonas, Brazil [PDF]

Pesquisa Agropecuária Brasileira, 2017
: The objective of this work was to evaluate corn cultivars grown in the state of Amazonas, Brazil, which simultaneously show high grain yield, adaptability, and stability.
Inocencio Junior de Oliveira, André Luiz Atroch, Miguel Costa Dias, Lauro José Guimarães, Paulo Evaristo de Oliveira Guimarães   +4 more
doaj   +3 more sources

Selection of white oat genotypes for contrasting fungicide management conditions

Pesquisa Agropecuária Brasileira, 2023
The objective of this work was to select white oat (Avena sativa) genotypes for environments with and without fungicide application, as well as to identify relationships between meteorological variables and agronomic traits.
Júlio Daronco Berlezi, Ivan Ricardo Carvalho, José Antonio Gonzalez da Silva, Murilo Vieira Loro, Inaê Carolina Sfalcin, Leonardo Cesar Pradebon, Eduarda Donadel Port, Rafael Soares Ourique, João Pedro Dalla Roza   +8 more
doaj   +1 more source

Genotype X Environment Interaction of Food Barley

Ecoprint: An International Journal of Ecology, 2015
The objective of this experiment was to estimate the magnitude of genotype X environment interaction on grain yield and yield related traits. Twelve varieties of food barley were included in the study planted in randomized complete block design with three replications. The ANOVA of combined and individual location revealed significant differences among
openaire   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Temporal stability of growth and yield among Hevea genotypes introduced to a non-traditional rubber growing region of peninsular India [PDF]

Annals of Forest Research, 2010
Extensive cultivation of Hevea brasiliensis in India now focus onnon-traditional regions for rubber cultivation. As a prelude for selection of genotypes for commercial cultivation, many introduced genotypes are being tested in genotype adaptation ...
K.K. Vinod, M. Suryakumar, T.R. Chandrasekhar, M.A. Nazeer   +3 more
doaj  

GENOTYPE x ENVIRONMENT INTERACTION WITH ISOGENIC LINES OF DROSOPHILA MELANOGASTER [PDF]

Genetics, 1963
Two experiments which exploit some of the peculiar genetic properties of Drosophila melanogaster were conducted to study the nature of the interaction of genotype x environment. All possible crosses were made among four isogenic lines, each representing a different mass mated stock.
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source