Results 51 to 60 of about 243,271 (342)

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Yield stability in cassava (Manihot esculenta, Crantz) cultivars in the north and northwest regions of Paraná State

Crop Breeding and Applied Biotechnology, 2002
A study was carried out to investigate the genotype x environment interaction and study the yield stability of storage roots in eight cassava cultivars, using methodologies by Plaisted and Peterson (1959), Lin and Binns (1988) and Kang (1988), in the ...
Fabrício Rimoldi, Pedro Soares Vidigal Filho, Maria Celeste Gonçalves Vidigal, Antônio Teixeira do Amaral Júnior, Rogério Rui Maia, Marcus Vinicius Kvitschal, Edvaldo Sagrilo   +6 more
doaj  

Cerebellum Transcriptome of Mice Bred for High Voluntary Activity Offers Insights into Locomotor Control and Reward-Dependent Behaviors. [PDF]

, 2016
The role of the cerebellum in motivation and addictive behaviors is less understood than that in control and coordination of movements. High running can be a self-rewarding behavior exhibiting addictive properties.
Caetano-Anollés, Kelsey, Garland, Theodore, Hernandez, Alvaro G, Perez, Sam D, Rhodes, Justin S, Rodriguez-Zas, Sandra L, Southey, Bruce R   +6 more
core   +2 more sources

Structure Formation in Butterfly Scales: Interplay of Genetic Control, Mechanical Instabilities, and Dynamic Material Properties

Advanced Functional Materials, EarlyView.
Butterfly wing scales are intricate cuticular functional nanosctructures. This perspective suggests that spatially varying material properties, cytoskeletal constraints, and growth‐driven mechanical instabilities shape the resulting nanoscale architectures created from single cells.
Anupama Prakash, Victoria Lloyd, Yi Yang, Anna‐Lee Jessop, Anthony McDougal, Primož Pirih, Guillaume Duclos, Andrew Parnell, Mathias Kolle, Nicola J. Nadeau, Bodo D. Wilts   +10 more
wiley   +1 more source

Influence of the environmental index on the estimation of stability parameters of Eberhart and Russell

Crop Breeding and Applied Biotechnology, 2004
The objective of this study was to verify the influence of the environmental index on the analysis and estimates of adaptability and stability parameters, using environmental indices obtained from four genotype groups (A, B, C, and QPM).
Cleso Antônio Patto Pacheco, Antônio Carlos de Oliveira, Elto Eugênio Gomes e Gama, Manoel Xavier dos Santos, Sidney Netto Parentoni, Walter Fernandes Meirelles, Paulo Evaristo de Oliveira Guimarães, Pedro Hélio Estevam Ribeiro   +7 more
doaj  

Genotype x environment interaction on experimental hybrids of chili pepper

Genetics and Molecular Research, 2017
In Brazil, cultivation of hybrid plants comprise near 40% of the area grown with vegetables. For Capsicum, hybrids of bell and chili peppers have already exceeded 50% and over 25% of all are commercialized seeds. This study aimed to evaluate new pepper hybrids in two environments, Cáceres, MT, and Campos dos Goytacazes, RJ, Brazil.
N S S, Cabral, A M, Medeiros, L G, Neves, C P, Sudré, S, Pimenta, V J, Coelho, M E, Serafim, R, Rodrigues   +7 more
openaire   +2 more sources

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Bayesian semiparametric analysis for two-phase studies of gene-environment interaction [PDF]

, 2013
The two-phase sampling design is a cost-efficient way of collecting expensive covariate information on a judiciously selected subsample. It is natural to apply such a strategy for collecting genetic data in a subsample enriched for exposure to ...
Ahn, Jaeil, Ghosh, Malay, Gruber, Stephen B., Mukherjee, Bhramar   +3 more
core   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Genotype x Environment interaction for kernel yield in groundnut (Arachis hypogaea L.) [PDF]

Electronic Journal of Plant Breeding, 2010
Sixteen medium duration groundnut cultures were evaluated for kernel yield, stability and adaptation across fourenvironments. The G X E interaction was highly significant and both linear and non-linear component are equally importantfor yield stability ...
A. Mothilal, P. Vindhiya varman and N. Manivannan
doaj