Results 41 to 50 of about 79,703 (301)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Analysis of the Environmental Component of Genotype X Environment Interaction in Crop Adaptation Evaluation [PDF]
, 1991 Cluster analysis has been useful in summarizing patterns of genotypic performance and environmental productivity when there is a significant amount of genotype x environment (G x E) interaction confounding the plant breeder.
Ivory, DA +3 more
core +1 more source
Annals of Forest Research, 2013 Extensive cultivation of Hevea brasiliensis in India now focus on non-traditional regions for rubber cultivation. As a prelude for selection of genotypes for commercial cultivation, many introduced genotypes are being tested in genotype adaptation ...
K.K. Vinod +3 more
doaj +1 more source
GENOTYPE x ENVIRONMENT INTERACTION WITH ISOGENIC LINES OF DROSOPHILA MELANOGASTER [PDF]
Genetics, 1963 Two experiments which exploit some of the peculiar genetic properties of Drosophila melanogaster were conducted to study the nature of the interaction of genotype x environment. All possible crosses were made among four isogenic lines, each representing a different mass mated stock.
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Application of nonlinear factor analysis to genotype-environment interaction [PDF]
, 1987 The intention of this paper is to show how the methods of nonlinear factor analysis as developed by McDonald (Br. J. Math. Stat. Psychol. 20:205-215, 1967) can be used to study genotype-environment interaction. The method is applied to the interaction of
Boomsma, D.I. +4 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Pesquisa Agropecuária Brasileira, 2022 The objective of this work was to decompose the variations of the genotype × environment interaction through fixed multivariate models, as well as to understand the genetic variations through mixed models, for the estimation and prediction of the genetic
Kassiana Kehl +7 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source