Results 41 to 50 of about 79,665 (301)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Pesquisa Agropecuária Brasileira, 2022 The objective of this work was to decompose the variations of the genotype × environment interaction through fixed multivariate models, as well as to understand the genetic variations through mixed models, for the estimation and prediction of the genetic
Kassiana Kehl +7 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Genotype-Environment Interaction in Wheat
, 2001 Thirteen advance lines and three check varieties viz. , Chakwal-86, Pak-81 and Rawal-87 of wheat were planted at nine locations to estimate genotype x environment interaction.
Ashraf, Muhammad +3 more
core +1 more source
Crop Breeding and Applied Biotechnology, 2004 The objective of this study was to verify the influence of the environmental index on the analysis and estimates of adaptability and stability parameters, using environmental indices obtained from four genotype groups (A, B, C, and QPM).
Cleso Antônio Patto Pacheco +7 more
doaj
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Crop Breeding and Applied Biotechnology, 2002 A study was carried out to investigate the genotype x environment interaction and study the yield stability of storage roots in eight cassava cultivars, using methodologies by Plaisted and Peterson (1959), Lin and Binns (1988) and Kang (1988), in the ...
Fabrício Rimoldi +6 more
doaj
Genotype X Environment Interaction of Food Barley
Ecoprint: An International Journal of Ecology, 2015 The objective of this experiment was to estimate the magnitude of genotype X environment interaction on grain yield and yield related traits. Twelve varieties of food barley were included in the study planted in randomized complete block design with three replications. The ANOVA of combined and individual location revealed significant differences among
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source