Results 111 to 120 of about 767,691 (307)

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Taylor&Hoffman1-Genotypes-Original_Genepop-ALL_LOCI [PDF]

, 2013
Taylor&Hoffman1-Genotypes-Original_Genepop ...
Zachary Taylor (3319626), Hoffman, Susan, Susan Hoffman (3319623), Taylor, Zachary   +3 more
core   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Rotavirus genotypes in children with gastroenteritis in Erzurum: first detection of G12P[6] and G12P[8] genotypes in Turkey [PDF]

, 2016
Introduction : Rotavirus is one of the leading pathogens which cause acute gastroenteritis in children and is responsible for a substantial proportion of childhood deaths worldwide.
Aktaş, Osman, Hakan Aydin, Osman Aktaş, Aydın, Hakan   +3 more
core   +1 more source

Molecular detection of the Hepatitis C virus genotypes circulating among both sexes of Khyber Pakhtunkhwa, Pakistan

Asian Journal of Medical Sciences, 2014
Background: Hepatitis C Virus (HCV) is the major cause of viral hepatitis. A few studies revealed that HCV genotypes; 3a, 3b, 1a and 1b are the most common genotypes found in the general population of Khyber Pakhtunkhwa.
Muhammad Waqar
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Inference of haplotypic phase and missing genotypes in polyploid organisms and variable copy number genomic regions [PDF]

, 2008
Background: The power of haplotype-based methods for association studies, identification of regions under selection, and ancestral inference, is well-established for diploid organisms.
Coin, LJM, White, J, Balding, DJ, Shu-Yi Su, Balding David J, Coin, Lachlan J. M., Su Shu-Yi, White, Jonathan, Balding, David J., Su, Shu-Yi, Jonathan White, Su, SY, Lachlan J.M. Coin, White Jonathan, Coin Lachlan JM, David J. Balding   +15 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

imputed-seq-genotypes-12k-Chr15.27860000-28860000.vcf [PDF]

, 2017
Imputed genotypes for variants within 1Mbp of the Chr15:28.36 LC QTL, for 12,000 ...
Thomas Lopdell (511314), Russell Snell (387740), Davis, Steve, Christine Couldrey (169434), Maksim Struchalin (166855), Steve Davis (5017841), Kathryn Tiplady (511313), Littlejohn, Mathew, Couldrey, Christine, Spelman, Richard, Struchalin, Maksim, Thomas Johnson (363281), Ric Sherlock (511317), Mathew Littlejohn (4690033), Tiplady, Kathryn, Sherlock, Ric, Richard Spelman (387738), Lopdell, Thomas, Johnson, Thomas, Keehan, Michael, Michael Keehan (4690036), Snell, Russell   +21 more
core   +1 more source

Altura de planta e acúmulo de matéria seca do feijoeiro cvs. BRS MG Talismã e Ouro Negro em plantio direto e convencional Plant height and dry matter acumulation by common bean cvs. BRS MG Talismã and Ouro Negro under no-tillage and conventional crop systems

Ciência e Agrotecnologia, 2008
Com o objetivo de estudar a curva de crescimento em altura de planta, taxa e acúmulo de matéria seca da parte aérea ao longo do ciclo cultural do feijoeiro (Phaseolus vulgaris L.) foram conduzidos quatro experimentos de campo, com as cvs.
Neiva Maria Batista Vieira, Messias José Bastos de Andrade, Janice Guedes de Carvalho, Jainir Alves Junior, Augusto Ramalho Morais   +4 more
doaj   +1 more source