Results 111 to 120 of about 863,797 (309)
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
imputed-seq-genotypes-12k-Chr20.57950000-58950000.vcf
, 2017 Imputed genotypes for variants within 1Mbp of the Chr20:58.45 LC QTL, for 12,000 ...
Thomas Lopdell (511314) +10 more
core +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
imputed-seq-genotypes-Chr20.31190000-32190000.vcf
, 2017 Imputed genotypes for variants within 1Mbp of the Chr20:31.69 LY QTL, for 357 ...
Thomas Lopdell (511314) +10 more
core +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
imputed-seq-genotypes-12k-Chr3.15020000-16020000.vcf
, 2017 Imputed genotypes for variants within 1Mbp of the Chr3:15.52 LC QTL, for 12,000 ...
Thomas Lopdell (511314) +10 more
core +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Thalassemia: genotypes and phenotypes
Annals of Hematology, 1991 The large degree of phenotypic heterogeneity of thalassemia can now be related to the underlying genomic defects. This information has accumulated rapidly over the last years through the recent advances in molecular technology. The list of main types of thalassemia (alpha or beta) that can be differentiated includes several gene deletions (complete or ...
openaire +5 more sources
imputed-seq-genotypes-12k-Chr16.24490000-25490000.vcf
, 2017 Imputed genotypes for variants within 1Mbp of the Chr16:24.99 LC QTL, for 12,000 ...
Thomas Lopdell (511314) +10 more
core +1 more source
FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source