Results 91 to 100 of about 767,691 (307)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

imputed-seq-genotypes-Chr20.31190000-32190000.vcf [PDF]

, 2017
Imputed genotypes for variants within 1Mbp of the Chr20:31.69 LY QTL, for 357 ...
Thomas Lopdell (511314), Thomas Johnson (363281), Russell Snell (387740), Christine Couldrey (169434), Maksim Struchalin (166855), Ric Sherlock (511317), Mathew Littlejohn (4690033), Steve Davis (5017841), Kathryn Tiplady (511313), Richard Spelman (387738), Michael Keehan (4690036)   +10 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

imputed-seq-genotypes-Chr29.9110000-10110000.vcf [PDF]

, 2017
Imputed genotypes for variants within 1Mbp of the Chr29:9.61 LC QTL, for 357 ...
Thomas Lopdell (511314), Thomas Johnson (363281), Russell Snell (387740), Christine Couldrey (169434), Maksim Struchalin (166855), Ric Sherlock (511317), Mathew Littlejohn (4690033), Steve Davis (5017841), Kathryn Tiplady (511313), Richard Spelman (387738), Michael Keehan (4690036)   +10 more
core   +1 more source

Participatory on-farm evaluation of wheat genotypes

Journal of Agriculture and Natural Resources, 2019
In wheat development programs, the evaluation and identification of superior genotypes is the first and leading step in a crop improvement program. Coordinated Farmer’s Field Trial (CFFT) was conducted during the three successive wheat growing season of
Deepak Pandey, Hemant Kumar Chaudhari, Shesh Raman Upadhyay, Nutan Raj Gautam, Bhakti Ram Ghimire, Jiban Shrestha, Dhruba Bahadur Thapa   +6 more
doaj   +1 more source

Phenotypic and Genotypic Characterization of Clinical Isolates Belonging to the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) Complex Isolated From Animals Treated at a Veterinary Hospital in Switzerland

Frontiers in Veterinary Science, 2019
Objectives: We investigated a collection of strains belonging to the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex obtained from a veterinary clinic with regard to their genetic relatedness, presence of antibiotic resistance genes and
Sabrina Püntener-Simmen, Katrin Zurfluh, Sarah Schmitt, Roger Stephan, Magdalena Nüesch-Inderbinen   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

imputed-seq-genotypes-12k-Chr16.24490000-25490000.vcf [PDF]

, 2017
Imputed genotypes for variants within 1Mbp of the Chr16:24.99 LC QTL, for 12,000 ...
Thomas Lopdell (511314), Thomas Johnson (363281), Russell Snell (387740), Christine Couldrey (169434), Maksim Struchalin (166855), Ric Sherlock (511317), Mathew Littlejohn (4690033), Steve Davis (5017841), Kathryn Tiplady (511313), Richard Spelman (387738), Michael Keehan (4690036)   +10 more
core   +1 more source

Associations of different genotypes with the meat productivity of sheep

Юг России: экология, развитие
Identification of the potential to increasthe agricultural production of farm animals has become possible through the use of genomic selection methods. It is advisable to improve breeding and pedigree qualities of local breeds, since these have the best ...
A. A. Ozdemirov, A. A. Khozhokov, R. A. Akaeva, E. M. Alieva, P. O. Alieva, Z. M. Guseynova, M. A. Daveteeva   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source