Results 71 to 80 of about 1,140,023 (282)

Immunomodulatory Function of HBeAg Related to Short-Sighted Evolution, Transmissibility, and Clinical Manifestation of Hepatitis B Virus

Frontiers in Microbiology, 2018
Hepatitis B virus (HBV) infection, a global public health problem can be asymptomatic, acute or chronic and can lead to serious consequences of infection, including cirrhosis, and hepatocellular carcinoma.
Anna Kramvis, Evangelia-Georgia Kostaki, Angelos Hatzakis, Dimitrios Paraskevis   +3 more
doaj   +1 more source

In vitro screening of four genotypes of citrus for salt tolerance : S08P07 [PDF]

, 2012
Soil and water salinity is an important abiotic stress that can affect both production and quality of citrus. The use of tolerant rootstocks in these conditions would be the solution the most used.
Benkirane, Rachid, Benyahia, Hamid, Chetto, Ouiam, Dambier, Dominique, Fadli, Anas, Talha, T.A.   +5 more
core  

Stomatal behavior of cowpea genotypes grown under varying moisture levels [PDF]

, 2017
Drought is a major limitation to crop productivity worldwide. Plants lose most of their water through stomata, thus making stomata an important organ in the control of transpiration and photosynthesis.
Ayisi, Kingsley, Boeckx, Pascal, Haesaert, Geert, Munjonji, Lawrence   +3 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dabie bandavirus identified from patients with severe fever with thrombocytopenia syndrome in northwestern of Hubei Province, China, 2024

Frontiers in Public Health
IntroductionSevere fever with thrombocytopenia syndrome (SFTS), caused by Dabie bandavirus (DBV), is a zoonotic disease characterized by substantial mortality. Hubei Province is an epidemic region with a high incidence rate of SFTS.
Mengzhu Zhang, Peixi Fu, ZhongJi Meng, Yuqian He, Xueqin Qin, Sen Luo, Yunzhen Xu, Li Liu, Guangyu Qiu, Yang Liu, Yanli Peng, Fangmin Song, Tianyi Xu, Jiao Yin, Mingming Liu, Chuanmin Wang   +15 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Role of MHC-II Diversity over Enclosure Design in Gut Microbiota Structuring of Captive Bengal Slow Lorises

Biology
The endangered Bengal slow loris (Nycticebus bengalensis) relies heavily on captive/rescue populations for conservation. This study investigated the critical link between Major Histocompatibility Complex (MHC) class II DRB1 exon 2 (DRB1e2) genetic ...
Rong Jiang, Xiaojia Zhang, Lei Xie, Yan Zhang, Changjun Zeng, Yongfang Yao, Huailiang Xu, Caoyang Yang, Xiao Wang, Qingyong Ni, Meng Xie, Chuanren Li   +11 more
doaj   +1 more source

EFFECTIVE CACAO SOMATIC EMBRYO REGENERATION ON KINETIN SUPPLEMENTED DKW MEDIUM AND SOMACLONAL VARIATION ASSESSMENT USING SSRs MARKERS

AGRIVITA Journal of Agricultural Science, 2016
This study aimed to develop the cacao (Theobroma cacao L.) in vitro regeneration system through somatic embryogenesis on kinetin supplemented DKW medium and somaclonal variation assessment using SSR markers.
Nur Ajijah, Rr Sri Hartati, Rubiyo, Dewi Sukma, Sudarsono   +4 more
doaj   +1 more source

Rescue of a genotype 4 human hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs [PDF]

, 2012
Hepatitis E virus (HEV) is an important but extremely understudied human pathogen. Genotypes 1 and 2 are restricted to humans, whereas genotypes 3 and 4 are zoonotic, infecting both humans and pigs.
Alicia R. Feagins, Barbara A. Dryman, Caitlin M. Cossaboom, Emerson, Feagins, Geissler, Laura Córdoba, Li, Meng, Meng, Moss, Strauss, Tanja Opriessnig, Xiang-Jin Meng, Yao-Wei Huang, Zafrullah   +15 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source