Results 51 to 60 of about 863,797 (309)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Clinical Characteristics and Genetic Variants in Children with PAX2 Mutation-Associated Disorders

Medicina
Background and Objectives: PAX2 serves as a critical transcription factor integral to the process of embryogenesis. Variations in the PAX2 gene could result in the aberrant development of numerous organs.
Yanyan Jin, Na Li, Zipei Chen, Ke Zeng, Jingjing Wang, Aiqin Sheng, Haidong Fu, Lidan Hu, Jianhua Mao   +8 more
doaj   +1 more source

Development of an Online Tool for Pasteurella multocida Genotyping and Genotypes of Pasteurella multocida From Different Hosts

Frontiers in Veterinary Science, 2021
Pasteurella multocida is a versatile zoonotic pathogen. Multiple systems have been applied to type P. multocida from different diseases in different hosts. Recently, we found that assigning P.
Zhong Peng, Junyang Liu, Wan Liang, Wan Liang, Fei Wang, Li Wang, Xueying Wang, Lin Hua, Huanchun Chen, Brenda A. Wilson, Jia Wang, Bin Wu   +11 more
doaj   +1 more source

Scofield-et-al_AmNat_52938_Quercus-agrifolia_pericarp-genotypes

, 2015
Genotypes of Quercus agrifolia collected from Acorn Woodpecker granaries at Sedgwick Reserve, Santa Barbara County, California, in 2006. Data are in GenAlEx format and represent diploid microsatellite genotypes.
Douglas G. Scofield (3311949), Peter E. Smouse (8028170), Jordan Karubian (150870), Victoria L. Sork (2903024)   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Steatosis in chronic hepatitis B: Prevalence and correlation with biochemical, histologic, viral, and metabolic parameters

Indian Journal of Pathology and Microbiology, 2011
Background and Aims: Hepatic steatosis (HS) is highly prevalent in chronic hepatitis C and is an important variable predicting progression of histological injury, insulin resistance, and reduced response to antiviral therapy. There are limited data on HS
Archana Rastogi, Puja Sakhuja, Ashish Kumar, Syed Hissar, Akshat Jain, Ranjana Gondal, Shiv Kumar Sarin   +6 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Scofield-et-al_AmNat_52938_Quercus-agrifolia_adult-genotypes

, 2015
Genotypes of adult Quercus agrifolia trees found in the study area of Sedgwick Reserve, Santa Barbara County, California. Data are in GenAlEx format, and represent diploid microsatellite genotypes at 10 loci. Loci are named following Scofield et al. 2010
Douglas G. Scofield (3311949), Peter E. Smouse (8028170), Jordan Karubian (150870), Victoria L. Sork (2903024)   +3 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Comparative Morphological Evaluation of Different Chilli (Capsicum annuum L.) Varieties of Andhra Pradesh, India for Agronomic Traits [PDF]

Journal of Stress Physiology & Biochemistry, 2019
In the present study, 20 chilli cultivars were characterized based on morphology as it serves as discrete identification indicator and also propose to evaluate cultivar diversity for yield related parameters.
Naganirmala Kumari Bantu, Mallikarjuna Kokkanti   +1 more
doaj