Results 161 to 170 of about 214,572 (265)

Multi-trait selection defines a plant-architecture ideotype for soybean in the Russian Far East. [PDF]

Front Plant Sci
Habib Y, Aseeva T, Shepel O, Potokina E.
europepmc   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Integrated evaluation of rapid diagnostic testing, genotypic-phenotypic resistance profiling, and AI-Assisted prediction models for antimicrobial stewardship and clinical outcomes in a resource-limited setting. [PDF]

PLoS One
Hammad M, Arif R, Fardoos S, Shakoor K, Nasir A.   +4 more
europepmc   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Complex effects of sex reversal on reproductive success in wild frogs. [PDF]

Sci Adv
Bókony V, Balogh E, Ujhegyi N, Mikó Z, Kásler A, Ujszegi J, Hettyey A, Herczeg D, Papp T, Nemesházi E.   +9 more
europepmc   +1 more source

Determination of genotypic and clinical characteristics of Colombian patients with mucopolysaccharidosis IVA

, 2018
Sandra M Tapiero-Rodriguez,1 Johanna C Acosta Guio,1 Gloria Liliana Porras-Hurtado,2 Natalia García,3 Martha Solano,4 Harry Pachajoa,5 Harvy M Velasco1 1Universidad Nacional de Colombia, Departamento de morfología, Maestría de gen ...
Velasco HM, Porras-Hurtado GL, Solano M, Pachajoa H, García N, Tapiero-Rodriguez SM, Acosta Guio JC   +6 more
core  

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

RETRACTED: Dewan et al. The Impact of <i>Fusobacterium nucleatum</i> and the Genotypic Biomarker KRAS on Colorectal Cancer Pathogenesis. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 6958. [PDF]

Int J Mol Sci
Dewan A, Tattoli I, Mascellino MT.
europepmc   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Efficiency under epistasis of haplotype-based genomic selection for pure line breeding. [PDF]

Heredity (Edinb)
Silva JPA, Viana JMS.
europepmc   +1 more source