Results 231 to 240 of about 214,572 (265)

MZF1 Inhibits TGFβ‐1/SMAD Signaling by Transcriptionally Activating SnoN to Augment Tumorigenic Potential in Colon Cancer

Advanced Science, EarlyView.
This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng, Mengxi Huang, Yiting Wang, Hongyu Wang, Haimei Feng, Xiaoming Bai, Jie Chen, Ke Xu, Xiaoyuan Chu, Zengjie Lei   +9 more
wiley   +1 more source

Evaluation of Multi-Breed Genomic Prediction Models for Carcass and Reproductive Traits in Zebu Beef Cattle. [PDF]

Anim Genet
Gubiani G, Temp L, Londoño-Gil M, Teodoro M, Oliveira E, Aguilar I, Bermann M, Lourenco D, Pereira ASC, Baldi F.   +9 more
europepmc   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

HIV-V3Augur: A Novel Machine Learning Model for Predicting HIV-1 Tropism in Sub-Subtype A6 and CRF63_02A6, Predominant Variants in Russia and Countries of the Former Soviet Union. [PDF]

Viruses
Elfimov K, Gotfrid L, Nokhova A, Gashnikova M, Ekushov V, Halikov M, Osipova I, Baboshko D, Murzin A, Kondeikin I, Kiryakina A, Totmenin A, Agaphonov A, Gashnikova N.   +13 more
europepmc   +1 more source

Multi-model genome-wide association analysis reveals natural allelic variation and candidate loci for kernel phytic acid content in quality protein maize. [PDF]

Front Genet
Kumar S, Kumar S, Saini DK, Rainy R, Das AK, Karjagi CG, Chaudhary D, Gaurav SS, Kumar R.   +8 more
europepmc   +1 more source

Role of casual contact in drug-resistant tuberculosis transmission: a molecular epidemiology study. [PDF]

Am J Respir Crit Care Med
Gandhi NR, Naidoo K, Lutchminarain K, Omar SV, Yoshii H, Willis F, Boodhram R, Gwala T, Campbell A, Coe MM, Evans AN, Tang L, Chitwood MH, Hlathi SR, Mbatha PN, Joseph L, Van Der Meulen H, Mlisana K, Jenness SM, Lurie MN, Kreiswirth BN, Warren JL, Nelson KN, Auld SC, Brust JCM, Cohen T, Mathema B, Shah NS.   +27 more
europepmc   +1 more source

Genotype Versus Phenotype in Pandrug-Resistant <i>Pseudomonas aeruginosa</i>: Key Considerations for Interpretation. [PDF]

Clin Med Insights Case Rep
Suvvari TK, Kandi V, Kocharlakota SV.
europepmc   +1 more source