Results 111 to 120 of about 55,687 (266)

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Genotypic variation of dormancy in wheat (Triticum aestivum L.) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science, Department of Plant Science, Massey University, Palmerston North, New Zealand [PDF]

, 1996
Embryo dormancy and α - amylase dormancy are desirable in wheat to minimise pre-harvest sprouting damage. The current work focuses on the embryo and graincoat colour.
Zvomuya, Norman
core  

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

Advanced Science, EarlyView.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao, Xin Wang, Jing Zhang, Ryan McQuinn, Je Min Lee, Itay Gonda, Ari Feder, Yimin Xu, Baike Wang, Qinghui Yu, Denise M. Tieman, Sanwen Huang, Harry Klee, James J. Giovannoni, Zhangjun Fei   +14 more
wiley   +1 more source

Variability, heritability and genetic advance for yield and quality components in interspecific F1 hybrids of cotton

Electronic Journal of Plant Breeding, 2017
Assessment of genetic variability using appropriate parameters like phenotypic coefficient of variation (PCV), genotypic coefficient of variation (GCV), heritability (h2), and genetic advance (GA) are really necessary to start an efficient breeding ...
Isong Abasianyanga and, P. Amala Balu
doaj   +1 more source

Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean

Advanced Science, EarlyView.
This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma, Hanyu Zhao, Haojie Feng, Xulun Dong, Lin Chen, Mingliang Yang, Runyi Chen, Chengjun Lei, Chunyan Liu, Qingshan Chen, Dawei Xin, Jinhui Wang   +11 more
wiley   +1 more source

Leveraging population admixture to characterize the heritability of complex traits. [PDF]

, 2014
Despite recent progress on estimating the heritability explained by genotyped SNPs (h(2)g), a large gap between h(2)g and estimates of total narrow-sense heritability (h(2)) remains.
Assimes, Themistocles L, Berndt, Sonja I, Bhatia, Gaurav, Blot, William J, Chanock, Stephen, Franceschini, Nora, Goodman, Phyllis G, Gusev, Alexander, Haiman, Christopher, He, Jing, Hennis, Anselm JM, Hsing, Ann, Ingles, Sue A, Isaacs, William, Kittles, Rick A, Klein, Eric A, Kooperberg, Charles, Lange, Leslie A, Nemesure, Barbara, Pasaniuc, Bogdan, Patterson, Nick, Pollack, Samuela, Price, Alkes L, Reich, David, Reiner, Alex P, Rybicki, Benjamin A, Sankararaman, Sriram, Stanford, Janet L, Stevens, Victoria L, Stram, Daniel, Strom, Sara S, Tandon, Arti, Tang, Hua, Vilhjálmsson, Bjarni J, Whitsel, Eric A, Wilson, James G, Witte, John S, Xu, Jianfeng, Young, Taylor, Zaitlen, Noah, Zhang, Jianqi   +40 more
core  

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Genetic variability studies in ADT 43/Seeraga samba cross derivatives of rice (Oryza sativa L.)

Electronic Journal of Plant Breeding, 2018
In the present investigation 11 quantitative characters viz., days to 50% flowering, plant height, flag leaf length, flag leaf width, leaf length, leaf width, number productive tillers, panicle length, number of filled grain, thousand grain weight ...
M. S. Bharath, M. Madhan Mohan, C. Vanniarajan, V. Veranan Arun Gridhari and, N. Senthil   +4 more
doaj   +1 more source

Association mapping in tetraploid potato [PDF]

, 2009
The results of a four year project within the Centre for BioSystems Genomics (www.cbsg.nl), entitled “Association mapping and family genotyping in potato” are described in this thesis.
hoop, B.B., D'
core  

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source