Results 191 to 200 of about 55,163 (272)

Mechanism‐informed machine learning for individualized tacrolimus dose adjustment in the early post‐kidney transplant period

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus dosing in the early post‐kidney transplant period is challenging due to a narrow therapeutic index and substantial interindividual pharmacokinetic (PK) variability. This study aimed to develop and validate mechanism‐informed machine learning (ML) models to support individualized tacrolimus dosing during this critical period ...
Hui Yu, Zihan Qin, Logan S. Smith, Jeong M. Park, Hao‐Jie Zhu   +4 more
wiley   +1 more source

Estimating Genetic Variability and Heritability of Morpho-Agronomic Traits of M5 Cowpea (<i>Vigna unguiculata</i> (L.) Walp) Mutant Lines. [PDF]

Int J Mol Sci
Ramolekwa K, Pholo-Tait M, Parker T, Malambane G, Ngwako S, Lekgari L.   +5 more
europepmc   +1 more source

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Leveraging probabilistic models to enhance soybean cultivar recommendation in Zimbabwe. [PDF]

BMC Plant Biol
Chagas JTB, Araújo MS, Martinez M, Pavan JPS, Mwadzingeni L, Mukaro R, Henderson A, Mutimaamba C, Scaboo A, Leles EP, Santos MF, Diers BW, Goldsmith P, Pinheiro JB.   +13 more
europepmc   +1 more source

The spread of non‐native species

Biological Reviews, EarlyView.
ABSTRACT The global redistribution of species through human agency is one of the defining ecological signatures of the Anthropocene, with biological invasions reshaping biodiversity patterns, ecosystem processes and services, and species interactions globally.
Phillip J. Haubrock, Ali Serhan Tarkan, Irene Martín‐Forés, Stelios Katsanevakis, Ronaldo Sousa, Ismael Soto, Andy J. Green, Antonín Kouba, Teun Everts, Victoria Dominguez Almela, Nadège Belouard, Cang Hui, Jamie Bojko, Victor Deklerck, Margaux Boeraeve, Franz Essl, J. Robert Britton   +16 more
wiley   +1 more source

Effect of genotype × environment interactions on starch physicochemical properties in diverse sorghum germplasm. [PDF]

Food Chem X
Zahid MK, Yu J, Hu Y, Lu H, Bao J.
europepmc   +1 more source

Comprehensive Characterization of Spelt Wheat and Common Wheat Protein and Viscosity Traits Under Different Field Management Systems

Cereal Chemistry, EarlyView.
ABSTRACT Background There is an increasing interest in healthier, nutrient‐rich foods so alternative grains produced in smaller quantities—including spelt wheat (Triticum spelta L.)—have once again become the focus of consumers. At the same time, the scientific proof of these claims is incomplete.
Edina Jaksics, Barnabás Pisch, Anna Csák, Viktor Boricsev, Eszter Takács, Alexandra Farkas, Bálint Tasi, Éva Pusztai, Viola Tóth, Marianna Rakszegi, Sándor Tömösközi   +10 more
wiley   +1 more source

Selection for high-yielding sugarcane ideotypes and multi-trait selection via MGIDI across different harvesting periods improves sugar quality and yield. [PDF]

Sci Rep
Barajehfard M, Fazli M, Fooladvand M, Salami M, Stevanato P, Heidari B.   +5 more
europepmc   +1 more source

Predicting cervical cancer DNA methylation from genetic data using multivariate CMMP

Canadian Journal of Statistics, EarlyView.
Abstract Epigenetic modifications link the environment to gene expression and play a crucial role in tumour development. DNA methylation, in particular, is gaining attention in cancer research, including cervical cancer, the focus of this study.
Hang Zhang, Steven Chen, Raymond Balise, Jiming Jiang, Nagi Ayad, J. Sunil Rao   +5 more
wiley   +1 more source

Evaluating multiple stability methods to screen bread wheat genotypes (F7 generation) under drought-stressed environments. [PDF]

PeerJ
Saed-Moucheshi A, Sasani S, Bakhtiar F, Roodi D, Sarikhani Khorami S.   +4 more
europepmc   +1 more source