Results 181 to 190 of about 131,669 (291)

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Appendix D. Correlations between measured O. biennis traits and ecosystem processes, and a figure showing the genotypic correlation between substrate induced respiration and two leaf chemical traits.

, 2016
Connor R. Fitzpatrick, Anurag A. Agrawal, Nathan Basiliko, Amy P. Hastings, Marney E. Isaac, Michael D. Preston, Marc T. J. Johnson   +6 more
openalex   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Analysis of genotypic and phenotypic correlations and path coefficients in 40 genotypes of rain-fed upland rice (Oryza sativa L.) in Oyo and Ogun States regions of Nigeria

Dans Johnson, Emmanuel Idehen, Isaac O. Abegunde   +2 more
openalex   +2 more sources

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Climatic Variables and Virulence May Contribute to the Population Dynamics of Pyricularia oryzae at Local Scale. [PDF]

Microbiologyopen
Bosco S, Sillo F, Ruffa P, Bergonzi L, Tenni D, Abbruscato P, Torello Marinoni D, Romani M, Spadaro D.   +8 more
europepmc   +1 more source

Dissecting trait associations in maize (Zea mays L.) through phenotypic and genotypic correlation coefficient analysis [PDF]

W. Sagar, Deepak Sapkal, Kevin Gawali, Mukesh Rathod, Ashish Sarda   +4 more
openalex   +1 more source

Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge [PDF]

, 2015
Giuseppe Pelosi, Alessandra Fabbri, Mauro Papotti, Giulio Rossi, Alberto Cavazza, Luisella Righi, Elena Tamborini, Federica Perrone, Giulio Settanni, Adele Busico, M. Testi, Patrick Maisonneuve, Filippo de Braud, Marina Chiara Garassino, Barbara Valeri, Angelica Sonzogni, Ugo Pastorino   +16 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Stress-resilient maize hybrids with stable agronomic performance: a pursuit to strengthen sustainable maize production in India. [PDF]

Front Plant Sci
Kumar R, Kondajji YR, Das AK, Kumar S, Kaur Y, Kumar K, S J, Karjagi CG, Patel MB, Karad S, Jat BS, Zaidi PH, Jat HS.   +12 more
europepmc   +1 more source