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Genetic Association Studies [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 The widespread availability of DNA from large population studies, the development of rapid throughput genotyping assays, and the identification of numerous polymorphisms in genes of interest make it easier to perform genetic association studies in humans. We consider these studies appropriate areas of research in relation to atherosclerosis, thrombosis,
X. L. Wang
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Genetic model misspecification in genetic association studies [PDF]
BMC Research Notes, 2017 Objective The underlying model of the genetic determinant of a trait is generally not known with certainty a priori. Hence, in genetic association studies, a dominant model might be erroneously modelled as additive, an error investigated previously.
Amadou Gaye, Sharon K. Davis
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Linear regression in genetic association studies. [PDF]
PLoS ONE, 2013 In genomic research phenotype transformations are commonly used as a straightforward way to reach normality of the model outcome. Many researchers still believe it to be necessary for proper inference. Using regression simulations, we show that phenotype
Petra Bůžková
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Reporting and evaluating genetic association studies [PDF]
Respiratory Research, 2009 Genetic association studies have become an important part of our scientific landscape. This commentary discusses some basic scientific issues which should be considered when reporting and evaluating such studies including SNP Discovery, Genotyping and ...
Peters Stephen P
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A rapid review of genetic association studies of parent-of-origin effects and fetal growth [PDF]
Molecular and Cellular PediatricsBackground Genetic factors contribute, in part, to fetal growth restriction (FGR), a developmental condition of disrupted fetal development associated with serious health consequences.
Esther Joo Won Kang, Andrew Thomas Dewan
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Sex chromosomes and genetic association studies [PDF]
Genome Medicine, 2009 Although the literature concerning statistical testing for genotype-phenotype association in family-based and population-based studies is very extensive, until recently the sex chromosomes have received little attention. Here it is shown that the X chromosome in particular presents special problems with respect to efficient analysis of mixed-sex ...
Clayton, David G
openaire +5 more sources
Editorial: Genetic association studies in oil seeds [PDF]
Frontiers in GeneticsV. G. Shobhana +3 more
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Genetic Determinants of Premature Menopause in A Mashhad Population Cohort [PDF]
International Journal of Fertility and Sterility, 2021 Background: Premature menopause is characterized by amenorrhea before age of 40 years, markedly raised serumluteinizing hormone (LH) level, follicle-stimulating hormone (FSH) level and reduced serum level of estradiol.Genome-wide analysis suggested ...
Mohammad Reza Mirinezhad +9 more
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Brazilian Journal of Pharmaceutical Sciences, 2023 The aim of this study was to evaluate tumor necrosis factor alpha (TNF-α), interleukin (IL)- 17A/F levels in the serum of ankylosing spondylitis (AS) patients after anti-TNF therapy, in order to understand how these cytokines are involved in this ...
Fernanda Formaggi Lara-Armi +7 more
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Anais Brasileiros de Dermatologia, 2014 Vitiligo is a chronic stigmatizing disease, already known for millennia, which mainly affects melanocytes from epidermis basal layer, leading to the development of hypochromic and achromic patches. Its estimated prevalence is 0.5% worldwide.
Roberto Gomes Tarlé +3 more
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