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Genetic association studies in Thorax [PDF]
Thorax, 2005 A guide to assessing the validity of genetic association studies in respiratory disease Increasing knowledge regarding the extent of genetic variation in the human genome has led to an explosion of interest in performing genetic association studies in complex diseases.
I P, Hall, J D, Blakey
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Multiple Group Testing Procedures for Analysis of High-Dimensional Genomic Data [PDF]
Genomics & Informatics, 2016 In genetic association studies with high-dimensional genomic data, multiple group testing procedures are often required in order to identify disease/trait-related genes or genetic regions, where multiple genetic sites or variants are located within the ...
Hyoseok Ko, Kipoong Kim, Hokeun Sun
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Stroke Genetics: A Review and Update [PDF]
Journal of Stroke, 2014 Stroke genetics includes several topics of clinical interest, including (1) molecular genetic variations affecting risk of monogenic stroke syndromes; (2) molecular genetic variations affecting risk of common stroke syndromes, sometimes with specific ...
Arne Lindgren
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An inferential study of the phenotype for the chromosome 15q24 microdeletion syndrome: a bootstrap analysis [PDF]
PeerJ, 2016 In January 2012, a review of the cases of chromosome 15q24 microdeletion syndrome was published. However, this study did not include inferential statistics.
Antonio Palazón-Bru +4 more
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Genetic Association Studies [PDF]
Circulation, 2008 With the completion of the HapMap project1 and the development of technology that allows the examination of ≥1 million genetic polymorphisms at once, genetic association studies are becoming more comprehensive. This article first provides a brief overview of the rationale for genetic association studies; it then discusses the primary features ...
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Genetic variants related to physical activity or sedentary behaviour: a systematic review
International Journal of Behavioral Nutrition and Physical Activity, 2021 Background Research shows that part of the variation in physical activity and sedentary behaviour may be explained by genetic factors. Identifying genetic variants associated with physical activity and sedentary behaviour can improve causal inference in ...
Lene Aasdahl +7 more
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Genetic association studies [PDF]
Neurology, 2001 The urge to associate genetic markers with human traits or diseases has been around for centuries. The association of specific hair colors with certain personality types has a long tradition in folklore. The rate-limiting factor has been the availability of measurable genetic markers.
Thomas D. Bird +2 more
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Validation in Genetic Association Studies [PDF]
Briefings in Bioinformatics, 2011 Validation of genetic associations is understood to be a cornerstone for the scientific credibility of the results. To approach this topic, the general concept of genetic association studies is introduced briefly, followed by how the term 'validation' is used in the context of genetic association studies.
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Genome Medicine, 2022 Background Large medical centers in urban areas, like Los Angeles, care for a diverse patient population and offer the potential to study the interplay between genetic ancestry and social determinants of health.
Ruth Johnson +25 more
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