Assessment of Saffron Neuroprotective Properties in Rat Retina versus Light Damage [PDF]
Research Journal of Pharmacognosy, 2020 Background and objectives: Crocus sativus L. (Iridaceae) commonly known as saffron, is a popular spice which is used for its pleasant aroma and favored color.
Nayebali Ahmadi +7 more
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A polymorphism in the FAM13A gene confers protection against tuberculosis in Brazilian workers exposed to silica [PDF]
Jornal Brasileiro de PneumologiaObjective: Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis, which was recognized by the World Health Organization (WHO) as a global epidemic in 1993.
Marcos César Santos de Castro +9 more
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Integration of a Large-Scale Genetic Analysis Workbench Increases the Accessibility of a High-Performance Pathway-Based Analysis Method [PDF]
Genomics & Informatics, 2018 The rapid increase in genetic dataset volume has demanded extensive adoption of biological knowledge to reduce the computational complexity, and the biological pathway is one well-known source of such knowledge. In this regard, we have introduced a novel
Sungyoung Lee, Taesung Park
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A Rare Association of Atrial Septal Defect with Retinitis Pigmentosa in an Adult: Coincidence or Syndromic Link [PDF]
Journal of Clinical and Diagnostic ResearchAtrial Septal Defect (ASD) and Retinitis Pigmentosa (RP) are individually well-recognised clinical entities, but their co-occurrence in an adult patient without a defined syndromic diagnosis is exceptionally uncommon.
Sumedh Krishna, Vignesh Raveekumaran
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Genetic Association Studies [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 The widespread availability of DNA from large population studies, the development of rapid throughput genotyping assays, and the identification of numerous polymorphisms in genes of interest make it easier to perform genetic association studies in humans. We consider these studies appropriate areas of research in relation to atherosclerosis, thrombosis,
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ForestPMPlot: A Flexible Tool for Visualizing Heterogeneity Between Studies in Meta-analysis
G3: Genes, Genomes, Genetics, 2016 Meta-analysis has become a popular tool for genetic association studies to combine different genetic studies. A key challenge in meta-analysis is heterogeneity, or the differences in effect sizes between studies.
Eun Yong Kang +5 more
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AssocTests: An R Package for Genetic Association Studies
Journal of Statistical Software, 2020 The R package AssocTests provides some procedures which are commonly used in genetic association studies. These procedures are population stratification correction through eigenvectors, principal coordinates of clusterings, Tracy-Widom test, distance ...
Lin Wang, Wei Zhang, Qizhai Li
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Genetic Studies on Diabetic Microvascular Complications: Focusing on Genome-Wide Association Studies [PDF]
Endocrinology and Metabolism, 2015 Diabetes is a common metabolic disorder with a worldwide prevalence of 8.3% and is the leading cause of visual loss, end-stage renal disease and amputation.
Soo Heon Kwak, Kyong Soo Park
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Myopia genetics in genome-wide association and post-genome-wide association study era [PDF]
International Journal of Ophthalmology, 2019 Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has ...
Xuan Liao, Qing-Qing Tan, Chang-Jun Lan
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Random Forests for Genetic Association Studies [PDF]
Statistical Applications in Genetics and Molecular Biology, 2011 The Random Forests (RF) algorithm has become a commonly used machine learning algorithm for genetic association studies. It is well suited for genetic applications since it is both computationally efficient and models genetic causal mechanisms well. With its growing ubiquity, there has been inconsistent and less than optimal use of RF in the literature.
Benjamin A, Goldstein +2 more
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