Results 21 to 30 of about 2,467,569 (240)

Genetic variants related to physical activity or sedentary behaviour: a systematic review

International Journal of Behavioral Nutrition and Physical Activity, 2021
Background Research shows that part of the variation in physical activity and sedentary behaviour may be explained by genetic factors. Identifying genetic variants associated with physical activity and sedentary behaviour can improve causal inference in ...
Lene Aasdahl, Tom Ivar Lund Nilsen, Ingebrigt Meisingset, Anne Lovise Nordstoga, Kari Anne I. Evensen, Julie Paulsen, Paul Jarle Mork, Eivind Schjelderup Skarpsno   +7 more
doaj   +1 more source

Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative

Genome Medicine, 2022
Background Large medical centers in urban areas, like Los Angeles, care for a diverse patient population and offer the potential to study the interplay between genetic ancestry and social determinants of health.
Ruth Johnson, Yi Ding, Vidhya Venkateswaran, Arjun Bhattacharya, Kristin Boulier, Alec Chiu, Sergey Knyazev, Tommer Schwarz, Malika Freund, Lingyu Zhan, Kathryn S. Burch, Christa Caggiano, Brian Hill, Nadav Rakocz, Brunilda Balliu, Christopher T. Denny, Jae Hoon Sul, Noah Zaitlen, Valerie A. Arboleda, Eran Halperin, Sriram Sankararaman, Manish J. Butte, UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working Group, Clara Lajonchere, Daniel H. Geschwind, Bogdan Pasaniuc   +25 more
doaj   +1 more source

Ethnic differences in adiposity and diabetes risk – insights from genetic studies [PDF]

, 2020
Type 2 diabetes is more common in non-Europeans and starts at a younger age and at lower BMI cut-offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of disease with a focus on the role of
Bell, J.D., Bell, J.D., Thomas, E.L., Thomas, E.L., Whitcher, B., Whitcher, B., Yaghootkar, H., Yaghootkar, H.   +7 more
core   +2 more sources

Genetic association studies in Thorax [PDF]

Thorax, 2005
A guide to assessing the validity of genetic association studies in respiratory disease Increasing knowledge regarding the extent of genetic variation in the human genome has led to an explosion of interest in performing genetic association studies in complex diseases.
I P, Hall, J D, Blakey
openaire   +2 more sources

A polymorphism in the FAM13A gene confers protection against tuberculosis in Brazilian workers exposed to silica [PDF]

Jornal Brasileiro de Pneumologia
Objective: Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis, which was recognized by the World Health Organization (WHO) as a global epidemic in 1993.
Marcos César Santos de Castro, Angela Santos Ferreira Nani, Kaio Cezar Rodrigues Salum, Lucas de Carvalho Costa, Valéria Barbosa Moreira, Hermano Albuquerque de Castro, Patrícia Canto Ribeiro, Walter Costa, Cícero Brasileiro de Mello, Fabiana Barzotto Kohlrausch   +9 more
doaj   +1 more source

Integration of a Large-Scale Genetic Analysis Workbench Increases the Accessibility of a High-Performance Pathway-Based Analysis Method [PDF]

Genomics & Informatics, 2018
The rapid increase in genetic dataset volume has demanded extensive adoption of biological knowledge to reduce the computational complexity, and the biological pathway is one well-known source of such knowledge. In this regard, we have introduced a novel
Sungyoung Lee, Taesung Park
doaj   +1 more source

iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. [PDF]

, 2017
Large-scale collections of induced pluripotent stem cells (iPSCs) could serve as powerful model systems for examining how genetic variation affects biology and disease.
Adler, Eric, Aguirre, Aitor, Arias, Angelo D, Benaglio, Paola, Berggren, W Travis, Borja, Victor, Chi, Neil C, Cook, Megan, D'Antonio, Matteo, D'Antonio-Chronowska, Agnieszka, Dargitz, Carl T, DeBoever, Christopher, Diffenderfer, Kenneth E, Donovan, Margaret KR, Drees, Frauke, Evans, Sylvia M, Farnam, KathyJean, Feiring, Rachel, Frazer, Kelly A, Garcia, Melvin, Goldstein, Lawrence SB, Greenwald, William W, Grinstein, Jonathan D, Harismendy, Olivier, Hashem, Sherin I, Hishida, Yuriko, Izpisua Belmonte, Juan Carlos, Jakubosky, David A, Jepsen, Kristen, Li, He, Loring, Jeanne F, Matsui, Hiroko, McGarry, Thomas J, Miller, Carl A, Modesto, Veronica, Müller, Franz-Josef, Nariai, Naoki, Nelson, Bradley C, O'Connor, Daniel T, Okubo, Jonathan, Panopoulos, Athanasia D, Rao, Fangwen, Reyna, Joaquin, Schuldt, Bernhard M, Smith, Erin N, Williams, Roy, Yeo, Gene W, Zhao, Chang   +47 more
core   +2 more sources

The role of 39 psoriasis risk variants on age of psoriasis onset. [PDF]

, 2013
Recent genome-wide association studies (GWAS) have identified multiple genetic risk factors for psoriasis, but data on their association with age of onset have been marginally explored.
Butler, Daniel, Chen, Haoyan, Cordoro, Kelly, Debbaneh, Maya, Gupta, Rishu, Huynh, Monica, Kane, Sinae, Leon, Argentina, Levin, Ethan, Liao, Wilson, Lu, Yingchang, Millsop, Jillian W, Nguyen, Tien   +12 more
core   +2 more sources

Genetic Studies on Diabetic Microvascular Complications: Focusing on Genome-Wide Association Studies [PDF]

Endocrinology and Metabolism, 2015
Diabetes is a common metabolic disorder with a worldwide prevalence of 8.3% and is the leading cause of visual loss, end-stage renal disease and amputation.
Soo Heon Kwak, Kyong Soo Park
doaj   +1 more source

ForestPMPlot: A Flexible Tool for Visualizing Heterogeneity Between Studies in Meta-analysis

G3: Genes, Genomes, Genetics, 2016
Meta-analysis has become a popular tool for genetic association studies to combine different genetic studies. A key challenge in meta-analysis is heterogeneity, or the differences in effect sizes between studies.
Eun Yong Kang, Yurang Park, Xiao Li, Ayellet V. Segrè, Buhm Han, Eleazar Eskin   +5 more
doaj   +1 more source