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Population stratification and genetic association studies in South Asia [PDF]
, 2005 Population stratification and its influence on genetic association studies is a controversial topic. Although it has been suggested that stratification is unlikely to bias the results of association studies conducted in developed countries, convincing ...
Bittles, A.H.
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Frontiers in Cardiovascular Medicine, 2023 HIV-associated lipodystrophy (HIVLD) is a metabolic condition with an irregularity in the production of lipoprotein particles, and its occurrence varies among HIV-infected patients. MTP and ABCG2 genes have a role in the transport of lipoproteins.
HariOm Singh +12 more
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Multiple Group Testing Procedures for Analysis of High-Dimensional Genomic Data [PDF]
Genomics & Informatics, 2016 In genetic association studies with high-dimensional genomic data, multiple group testing procedures are often required in order to identify disease/trait-related genes or genetic regions, where multiple genetic sites or variants are located within the ...
Hyoseok Ko, Kipoong Kim, Hokeun Sun
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Genetic association studies [PDF]
Neurology, 2001 The urge to associate genetic markers with human traits or diseases has been around for centuries. The association of specific hair colors with certain personality types has a long tradition in folklore. The rate-limiting factor has been the availability of measurable genetic markers.
Thomas D. Bird +2 more
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Stroke Genetics: A Review and Update [PDF]
Journal of Stroke, 2014 Stroke genetics includes several topics of clinical interest, including (1) molecular genetic variations affecting risk of monogenic stroke syndromes; (2) molecular genetic variations affecting risk of common stroke syndromes, sometimes with specific ...
Arne Lindgren
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An inferential study of the phenotype for the chromosome 15q24 microdeletion syndrome: a bootstrap analysis [PDF]
PeerJ, 2016 In January 2012, a review of the cases of chromosome 15q24 microdeletion syndrome was published. However, this study did not include inferential statistics.
Antonio Palazón-Bru +4 more
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Genetic Association Studies [PDF]
Circulation, 2008 With the completion of the HapMap project1 and the development of technology that allows the examination of ≥1 million genetic polymorphisms at once, genetic association studies are becoming more comprehensive. This article first provides a brief overview of the rationale for genetic association studies; it then discusses the primary features ...
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Population Structure and Cryptic Relatedness in Genetic Association Studies [PDF]
, 2009 We review the problem of confounding in genetic association studies, which arises principally because of population structure and cryptic relatedness. Many treatments of the problem consider only a simple ``island'' model of population structure. We take
Astle, William, Balding, David J.
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Assessment of Saffron Neuroprotective Properties in Rat Retina versus Light Damage [PDF]
Research Journal of Pharmacognosy, 2020 Background and objectives: Crocus sativus L. (Iridaceae) commonly known as saffron, is a popular spice which is used for its pleasant aroma and favored color.
Nayebali Ahmadi +7 more
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Introduction to Genetic Association Studies [PDF]
Cold Spring Harbor Protocols, 2012 Genetic association studies are used to find candidate genes or genome regions that contribute to a specific disease by testing for a correlation between disease status and genetic variation. This article provides a broad outline of the design and analysis of such studies, focusing on case–control studies in candidate genes or regions.
Lewis, Cathryn M, Knight, Jo
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