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Design efficiency in genetic association studies [PDF]
Statistics in Medicine, 2020 Selecting the best design for genetic association studies requires careful deliberation; different study designs can be used to scan for different genetic effects, and each design has its own set of strengths and limitations. A variety of family and unrelated control configurations are amenable to genetic association analyses, including the case ...
Miriam Gjerdevik +6 more
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Myopia genetics in genome-wide association and post-genome-wide association study era [PDF]
International Journal of Ophthalmology, 2019 Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has ...
Xuan Liao, Qing-Qing Tan, Chang-Jun Lan
doaj +1 more source
Frontiers in Genetics, 2023 Determining genotype–phenotype correlations in patients with hypodontia is important for understanding disease pathogenesis, although only a few studies have elucidated it.
Shinyeop Lee +6 more
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Robust Tests in Genome-Wide Scans under Incomplete Linkage Disequilibrium [PDF]
, 2009 Under complete linkage disequilibrium (LD), robust tests often have greater power than Pearson's chi-square test and trend tests for the analysis of case-control genetic association studies.
Geller, Nancy +4 more
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AssocTests: An R Package for Genetic Association Studies
Journal of Statistical Software, 2020 The R package AssocTests provides some procedures which are commonly used in genetic association studies. These procedures are population stratification correction through eigenvectors, principal coordinates of clusterings, Tracy-Widom test, distance ...
Lin Wang, Wei Zhang, Qizhai Li
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Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study [PDF]
, 2005 Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle.
Almeida, C. +5 more
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Validation in Genetic Association Studies [PDF]
Briefings in Bioinformatics, 2011 Validation of genetic associations is understood to be a cornerstone for the scientific credibility of the results. To approach this topic, the general concept of genetic association studies is introduced briefly, followed by how the term 'validation' is used in the context of genetic association studies.
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Random Forests for Genetic Association Studies [PDF]
Statistical Applications in Genetics and Molecular Biology, 2011 The Random Forests (RF) algorithm has become a commonly used machine learning algorithm for genetic association studies. It is well suited for genetic applications since it is both computationally efficient and models genetic causal mechanisms well. With its growing ubiquity, there has been inconsistent and less than optimal use of RF in the literature.
Benjamin A, Goldstein +2 more
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Efficient inference for genetic association studies with multiple outcomes
, 2017 Combined inference for heterogeneous high-dimensional data is critical in modern biology, where clinical and various kinds of molecular data may be available from a single study.
Davison, Anthony C. +3 more
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Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers [PDF]
, 2007 Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level.
Mittelstrass, Kirstin +17 more
core +2 more sources