Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
BMC Cardiovascular Disorders, 2019 Background We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. Methods Published and individual participant level data (300,000+ participants)
Amand F. Schmidt +167 more
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Meta-Analysis of Genome-Wide Linkage Studies in Celiac Disease. [PDF]
, 2009 OBJECTIVE: A meta-analysis of genome-wide linkage studies allows us to summarize the extensive information available from family-based studies, as the field moves into genome-wide association studies. METHODS: Here we apply the genome scan meta-analysis
Babron MC +9 more
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Sample Size and Statistical Power Calculation in Genetic Association Studies [PDF]
Genomics & Informatics, 2012 A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases.
Eun Pyo Hong, Ji Wan Park
doaj +1 more source
Network assisted analysis to reveal the genetic basis of autism
, 2015 While studies show that autism is highly heritable, the nature of the genetic basis of this disorder remains illusive. Based on the idea that highly correlated genes are functionally interrelated and more likely to affect risk, we develop a novel ...
Lei, Jing, Liu, Li, Roeder, Kathryn
core +1 more source
Psychometric precision in phenotype definition is a useful step in molecular genetic investigation of psychiatric disorders [PDF]
, 2015 Affective disorders are highly heritable, but few genetic risk variants have been consistently replicated in molecular genetic association studies. The common method of defining psychiatric phenotypes in molecular genetic research is either a summation ...
A Brown +55 more
core +6 more sources
Bayesian Model Selection in Complex Linear Systems, as Illustrated in Genetic Association Studies [PDF]
, 2013 Motivated by examples from genetic association studies, this paper considers the model selection problem in a general complex linear model system and in a Bayesian framework.
+30 more
core +2 more sources
Genome-Wide Association Study of Bronchodilator Drug Response (BDR) in Minority Children with Asthma Provides Insights into Its Genetic Risk Factors [PDF]
, 2021 Jin Hui Joo +12 more
openalex +1 more source
Comparison of robust tests for genetic association using case-control studies
, 2006 In genetic studies of complex diseases, the underlying mode of inheritance is often not known. Thus, the most powerful test or other optimal procedure for one model, e.g. recessive, may be quite inefficient if another model, e.g.
Freidlin, Boris +2 more
core +1 more source
Modeling and Testing for Joint Association Using a Genetic Random Field Model [PDF]
, 2014 Substantial progress has been made in identifying single genetic variants predisposing to common complex diseases. Nonetheless, the genetic etiology of human diseases remains largely unknown.
Adler +24 more
core +2 more sources
Journal of Epidemiology, 2016 The STrengthening the REporting of Genetic Association studies (STREGA) statement was based on the STrengthening the REporting of OBservational studies in Epidemiology (STROBE) statement, and it was published in 2009 in order to improve the reporting ...
Darko Nedovic
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