Results 41 to 50 of about 2,467,569 (240)

Bayesian methods for genetic association analysis with heterogeneous subgroups: From meta-analyses to gene-environment interactions

, 2014
Genetic association analyses often involve data from multiple potentially-heterogeneous subgroups. The expected amount of heterogeneity can vary from modest (e.g., a typical meta-analysis) to large (e.g., a strong gene--environment interaction). However,
Stephens, Matthew, Wen, Xiaoquan
core   +1 more source

Polymorphic variants and risk of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus: systematic review and meta-analysis

BMC Endocrine Disorders
Background Neuropathy is a frequent complication of diabetes mellitus, a disease that is growing exponentially worldwide. Genetic research has emerged as an important tool for better understanding its predisposition, although a systematic synthesis of ...
Daniella Vinelli-Arzubiaga, Carmen Elizabeth Suasnabar Campos, María Cristina Laso-Salazar, Hugo Abarca-Barriga   +3 more
doaj   +1 more source

Population Stratification in Genetic Association Studies [PDF]

Current Protocols in Human Genetics, 2017
AbstractPopulation stratification (PS) is a primary consideration in studies of genetic determinants of human traits. Failure to control for PS may lead to confounding, causing a study to fail for lack of significant results, or resources to be wasted following false‐positive signals.
Jacklyn N, Hellwege, Jacob M, Keaton, Ayush, Giri, Xiaoyi, Gao, Digna R, Velez Edwards, Todd L, Edwards   +5 more
openaire   +2 more sources

Cytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association study [PDF]

, 2016
BACKGROUND The inflammatory cytokine cascade is implicated in the pathogenesis of necrotising enterocolitis (NEC). Genetic association studies of cytokine polymorphisms may help to detect molecular mechanisms that are causally related to the disease ...
Baier, R. J., Brocklehurst, P., Craig, S., Helps, N., Henderson, G., McGuire, W.   +5 more
core   +1 more source

Fractal Characterizations of MAX Statistical Distribution in Genetic Association Studies

, 2009
Two non-integer parameters are defined for MAX statistics, which are maxima of $d$ simpler test statistics. The first parameter, $d_{MAX}$, is the fractional number of tests, representing the equivalent numbers of independent tests in MAX.
Azzalini A., Heisenberg W., Mao J., Press W. H., Sham P., Sokal R. K., Thomas D. C., Weir B. S.   +7 more
core   +1 more source

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change. [PDF]

, 2020
In pharmacogenomic studies of quantitative change, any association between genetic variants and the pretreatment (baseline) measurement can bias the estimate of effect between those variants and drug response.
Haldar, Tanushree, Hoffmann, Thomas J, Iribarren, Carlos, Krauss, Ronald M, Medina, Marisa W, Oni-Orisan, Akinyemi, Ranatunga, Dilrini K, Risch, Neil, Schaefer, Catherine   +8 more
core   +2 more sources

Polymorphisms at 1q32, 8q24, and 17q22 loci are associated with nonsyndromic cleft lip with or without cleft palate risk in the Slovak population

Biomedical Papers, 2017
Background: Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is the most common orofacial birth defect with an aetiology involving both genetic and environmental factors.
Jan Salagovic, Lucia Klimcakova, Marianna Zabavnikova, Jana Behunova, Terezia Hudakova, Jozef Fedeles, Agata Molnarova, Ludmila Podracka   +7 more
doaj   +1 more source

Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults

Frontiers in Physiology, 2022
This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C>T polymorphism on different health-related parameters in male and female young adults.
Adrián Montes-de-Oca-García, Adrián Montes-de-Oca-García, Juan Corral-Pérez, Juan Corral-Pérez, Daniel Velázquez-Díaz, Daniel Velázquez-Díaz, Daniel Velázquez-Díaz, Alejandro Perez-Bey, Alejandro Perez-Bey, María Rebollo-Ramos, María Rebollo-Ramos, Alberto Marín-Galindo, Alberto Marín-Galindo, Félix Gómez-Gallego, Maria Calderon-Dominguez, Maria Calderon-Dominguez, Cristina Casals, Cristina Casals, Jesús G. Ponce-González, Jesús G. Ponce-González   +19 more
doaj   +1 more source

Rare Variant Modify Contribution of Common Genetic and Lifestyle Factors toward Type 2 Diabetes Mellitus [PDF]

Diabetes & Metabolism Journal
Background This study aimed to investigate the modifying effects of rare genetic variants on the risk of type 2 diabetes mellitus (T2DM) in the context of common genetic and lifestyle factors.
Hye-Mi Jang, Mi Yeong Hwang, Yi Seul Park, Bong-Jo Kim, Young Jin Kim   +4 more
doaj   +1 more source

Multi-ancestry genome-wide association study in all of Us for primary open-angle glaucoma

Scientific Reports
This study aims to identify new genetic loci associated with primary open-angle glaucoma (POAG) and explore shared genetic risk factors across African, European, and Admixed American/Latino populations. Genome-wide Association Study (GWAS) utilizing data
Kiana Tavakoli, Bonnie B. Huang, Tara Mirmira, Nichole Ma, Robert N. Weinreb, Sally L. Baxter   +5 more
doaj   +1 more source