Distribution of RET proto‐oncogene variants in children with appendicitis
Molecular Genetics & Genomic Medicine, 2022 Background In addition to patient‐related systemic factors directing the immune response, the pathomechanisms of appendicitis (AP) might also include insufficient drainage leading to inflammation caused by decreased peristalsis.
Jurek Schultz +7 more
doaj +1 more source
Genetic Dissection of Drought Resistance of Common Bean at the Seedling Stage by Genome-wide Association Study [PDF]
, 2021 Lei Wu +4 more
openalex +1 more source
Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders [PDF]
, 2016 Personality is influenced by genetic and environmental factors1 and associated with mental health. However, the underlying genetic determinants are largely unknown.
A Okbay +82 more
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Characterizing the mechanism behind the progression of NAFLD to hepatocellular carcinoma
Hepatic Oncology, 2020 Hepatocellular carcinoma (HCC) developed in non-alcoholic fatty liver disease (NAFLD) individuals presents substantial clinical and biological characteristics, which remain to be elucidated. Its occurrence in noncirrhotic patients raises issues regarding
Pierre Nahon +3 more
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GemTools: A fast and efficient approach to estimating genetic ancestry [PDF]
, 2011 To uncover the genetic basis of complex disease, individuals are often measured at a large number of genetic variants (usually SNPs) across the genome. GemTools provides computationally efficient tools for modeling genetic ancestry based on SNP genotypes.
Devlin, Bernie +4 more
core
Genes and primary headaches: discovering new potential therapeutic targets [PDF]
, 2013 Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors.
De Martino, Paola +8 more
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Robust tests for matched case-control genetic association studies
BMC Genetics, 2010 Background The Cochran-Armitage trend test (CATT) is powerful in detecting association between a susceptible marker and a disease. This test, however, may suffer from a substantial loss of power when the underlying genetic model is unknown and ...
Fung Wing, Zang Yong
doaj +1 more source
Modeling Haplotype-Haplotype Interactions in Case-Control Genetic Association Studies
Frontiers in Genetics, 2012 Haplotype analysis has been increasingly used to study the genetic basis of human diseases, but models for characterizing genetic interactions between haplotypes from different chromosomal regions have not been well developed in the current literature ...
Li eZhang +4 more
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Genetic association studies in complex diseases [PDF]
Journal of Human Hypertension, 2000 Genetic association studies are the most frequent type of study performed in the investigation of the genetic basis of complex cardiovascular conditions. While relatively easy to perform, and having previously correctly identified genetic effects subsequently proven to be due to genetic linkage, interpretation of the results of these studies is not ...
openaire +3 more sources
Genome-Wide Association and Linkage Analysis of Quantitative Traits: Comparison pf Likelihood-Ratio Test and Conditional Score Statistic [PDF]
, 2009 Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype.
Dupuis, Josée +2 more
core +1 more source