Results 201 to 210 of about 1,163,135 (344)

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source

Predicting resistance to biological therapy using human leukocyte antigen genes in patients with inflammatory bowel disease. [PDF]

Therap Adv Gastroenterol
Domingues Â, Carvalho A, Martinho A, Soares C, Martins D, Sousa P, Araújo R, Cancela E, Silva A, Ministro P.   +9 more
europepmc   +1 more source

Influence of Genotype and Mineral Nutrition on the Distribution of Growth within Plants of Lolium perenne L. grown in Soil [PDF]

, 1968
Arthur Troughton
openalex   +1 more source

Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice

Advanced Science, EarlyView.
The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeon Lee, Jennifer K. Grenier, Paul R. Munn, M. Cecilia Ljungberg, Rebecca B Williams, Rainer B. Lanz, Yu‐Hsiang Liao, Yi A. Ren   +11 more
wiley   +1 more source

Editorial: Brief research reports in pharmacogenetics and pharmacogenomics: 2022

Frontiers in Pharmacology, 2023
Francesco Sessa, Tarek Magdy, Tarek Magdy, Chonlaphat Sukasem, Chonlaphat Sukasem, George P. Patrinos, George P. Patrinos, George P. Patrinos   +7 more
doaj   +1 more source

Assessing the suitability of formalin-fixed paraffin-embedded (FFPE) tissue for genome-wide association studies (GWAS). [PDF]

BMC Res Notes
Reingruber J, Krämer MJ, Bigge J, Dasmeh P, Grover S, Heilmann-Heimbach S, Nöthen MM, Kreuser N, Gockel I, Veits L, Vieth M, Jank P, Denkert C, Maj C, Hess T, Schumacher J.   +15 more
europepmc   +1 more source

The importance of genotype by environment interaction with reference to control populations [PDF]

, 1962
David F. Bray, A. E. Bell, Steven C. King   +2 more
openalex   +1 more source

Restoration of SIRT3 Expression in Aged Mice Alleviates UUO‐Induced Renal Fibrosis by Reducing GSK‐3β Hyperacetylation

Advanced Science, EarlyView.
SIRT3 expression is significantly downregulated in the aged kidney, rendering the kidney more vulnerable to fibrotic changes in obstructive nephropathy. By promoting GSK‐3β deacetylation, SIRT3 indirectly inhibits Wnt/β‐catenin signaling, thereby suppressing renal fibrosis.
Jing Wang, Xiang Ren, Huan Lu, Zihao Guo, Xing Li, Yiqun Tian, Yisheng Yin, Zhenliang Qin, Kun Yun, Minglong Wu, Gang Chen, Xiaoyong Zeng   +11 more
wiley   +1 more source

Discrepancies Between Pathological Distinction and DNA Genotyping in the Diagnosis of Hydatidiform Moles. [PDF]

Cureus
Hasegawa Y, Nagata K, Miura S, Nagata A, Mishima H, Kinoshita A, Yoshiura KI, Miura K.   +7 more
europepmc   +1 more source

Influence of Sex on Selection II. Contributions of Autosomal Genotypes Having Different Values in the Two Sexes [PDF]

, 1966
B Griffing
openalex   +1 more source