Results 201 to 210 of about 181,932 (222)

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development

Advanced Science, EarlyView.
The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao, Tianxiang Tang, Bowen Wang, Shengfei He, Yue Zhang, Li Dong, Bo Xu, Ying Liu, Ping Zhu, Rui Guo   +9 more
wiley   +1 more source

Identification of NIBAN2‐Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis

Advanced Science, EarlyView.
NIBAN2 interacts with the HNRNPU‐cored spliceosome complex and alters its components to regulate the alternative splicing of RUNX2, which ultimately cause an increase in functional RUNX2 (nuclear localization sequence complete) but a decrease in dysfunctional Runx2 (exon 6‐exclusive) isoforms to reinforce osteoblast differentiation.
Sheng Zhang, Zhiqiang Yang, Yuanlong Xie, Yufeng Zhang, Zhe Chen, Xuan Lv, Zhouming Deng, Zan Huang, Lin Cai, Renxiong Wei   +9 more
wiley   +1 more source

Origins, Dispersal, and Impact: Bidirectional Introgression Between Chinese and European Pig Populations

Advanced Science, EarlyView.
This study investigates bidirectional introgression between Chinese and European pig populations, revealing 3558 introgressed genomic segments and 30 structural variations. Analysis of the BMP2 region suggests its role in body size enhancement. By integrating ancient and modern genomes, the study highlights the impact of introgression on genetic ...
Yibin Qiu, Langqing Liu, Min Huang, Donglin Ruan, Rongrong Ding, Zebin Zhang, Enqin Zheng, Shiyuan Wang, Shaoxiong Deng, Xianglun Meng, Xinyan Cheng, Jiaxin Shi, Yingshan Yang, Fuchen Zhou, Sixiu Huang, Huaqiang Yang, Zicong Li, Gengyuan Cai, Zhenfang Wu, Jie Yang   +19 more
wiley   +1 more source

Genotype-Environment Interaction in Laying Tests of Poultry

, 1962
Hans Abplanalp, Luis F. Marrou, Etsuo Goto   +2 more
openalex   +1 more source

MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue

Advanced Science, EarlyView.
This study demonstrates that MTCH2 acts as an evolutionarily conserved regulator of energy homeostasis across Drosophila, rodents, and humans. Adipose‐specific MTCH2 ablation enhances brown/beige adipose thermogenesis through Bcl‐2‐dependent autophagy, promoting energy expenditure and counteracting obesity‐associated metabolic disorders. These findings
Xin‐Yuan Zhao, Ben‐Chi Zhao, Hui‐Lin Li, Ying Liu, Bei Wang, An‐Qi Li, Tian‐Shu Zeng, Hannah Xiaoyan Hui, Jia Sun, Domagoj Cikes, Nele Gheldof, Jorg Hager, Jian‐Xun Mi, D. Ross Laybutt, Yin‐Yue Deng, Yan‐Chuan Shi, G. Gregory Neely, Qiao‐Ping Wang   +17 more
wiley   +1 more source

Social Behavior as Related to Down Pattern Genotype in Fayoumi Domestic Fowl

, 1967
A.E. Sefton, R. D. Crawford
openalex   +1 more source

Annexin A3 Represses Endothelial Permeability and Inflammation During Sepsis via Actin Cytoskeleton Modulation

Advanced Science, EarlyView.
Annexin A3 (ANXA3) plays an endogenous protective role in endothelial dysfunction in sepsis by stabilizing the actin cytoskeleton, modulating cell permeability, and inhibiting pATF2/CD62E inflammatory signaling. Abstract Increased endothelial permeability and a dysregulated inflammatory response play key roles in organ damage in sepsis.
Manyu Xing, Shuang Liang, Wei Cao, Qulian Guo, Wangyuan Zou   +4 more
wiley   +1 more source

An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors

Advanced Science, EarlyView.
A peptide library screening platform has been developed to discover covalent transcription factor inhibitors. It identifies an antagonist cysteine residue, which forms an inhibitory disulphide with cJun C269. Conversion of this cysteine to an electrophile generates an irreversible and selective cJun inhibitor, validating this approach for covalent ...
Andrew Brennan, Scott Lovell, Keith W Vance, Jody M Mason   +3 more
wiley   +1 more source

Genotype-Environment Interactions in Broiler Stocks of Chickens

, 1969
H.L. MARKS, C.H. Moore, N.R. Gyles, L.D. Tindell, William A. Johnson, L.J. Dreesen, W.L. Blow, Gerald A. Martin, W.F. Krueger, P.B. Siegel   +9 more
openalex   +1 more source

ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

Advanced Science, EarlyView.
RNA modification is crucial in fibrosis diseases, but the role of m1A modification remains elusive. This study reveals that ALKBH3, an m1A demethylase, drives skin fibrosis by reshaping m6A RNA modification and stabilizing COL1A1 and FN1 mRNAs through METTL3, uncovering a crosstalk between m1A and m6A methylation in pathological events.
Liying Tu, Shuchen Gu, Ruoqing Xu, En Yang, Xin Huang, Hsin Liang, Shenying Luo, Haizhou Li, Yixuan Zhao, Tao Zan   +9 more
wiley   +1 more source